Jackson AC, Liu J, Vallanat B, Jones C, Nelms MD, Patlewicz G , Corton JC. 2020. Identification of novel activators of the metal responsive transcription factor (MTF-1) using a gene expression biomarker in a microarray compendium. Metallomics 12(9):1400-1415; doi: 10.1039/d0mt00071j . PMID: 32661532.
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Publication: Manuscripts
/ Topics: Metals
Bell S, Abedini J, Ceger P, Chang X, Cook B, Karmaus AL, Lea I , Mansouri K, et al. 2020. An integrated chemical environment with tools for chemical safety testing. Toxicol in Vitro 67(Sept):104916; doi: 10.1016/j.tiv.2020.104916 . PMID: 32553663.
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Publication: Manuscripts
/ Topics: chemical safety assessment
Bhat VS, Cohen SM, Gordon EB, Wood CE, Cullen JM, Harris MA, Proctor DM, Thompson CM . 2020. An adverse outcome pathway for small intestinal tumors in mice involving chronic cytotoxicity and regenerative hyperplasia: A case study with hexavalent chromium, captan, and folpet. Crit Rev Toxicol 50(8)685-706; doi: 10.1080/10408444.2020.1823934 . PMID: 33146058.
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Publication: Manuscripts
/ Topics: Adverse outcome pathways (AOPs) , chromium
Fryzek J, Bylsma L, Mease K, Movva N, Welsh BT, Wood M . 2020. Critical insights into nonclinical toxicology and real-world evidence essential for a successful rare disease product launch. EpidStrategies, Inc. White Paper .
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Publication: White paper
/ Topics: nonclinical safety assessment
Eskes C, Corsini E, Hanley V, Karadjova I, Kopp-Schneider A, Suh M , Alves P, Clewell R, et al. 2020. ESAC opinion on the scientific validity of the bioelution test method. In: Viegas Barroso J (ed), EUR 30281 EN . Publications Office of the European Union, Luxembourg, ISBN 978-92-76-20004-8 (online), doi:10.2760/023005 (online), JRC121143.
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Publication: Report
/ Topics: test methods
Chappell GA, Wikoff DS , Doepker CL, Borghoff SJ . 2020. Lack of potential carcinogenicity for acesulfame potassium — Systematic evaluation and integration of mechanistic data into the totality of the evidence. Food Chem Toxicol 141(July):111375; doi: 10.1016/j.fct.2020.111375 . PMID: 32360221.
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Publication: Manuscripts
/ Topics: carcinogens , Systematic Review
Zorn KM, Foil DH, Russo DP, Clark AM, Hillwalker W, Feifarek D, Jones F, Klaren W , Brinkman A, Ekins S. Generation of machine-learning models to anticipate endocrine disruption. Society of Toxicology 59th Annual Meeting, Virtual, 2020.
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Publication: Abstracts and Presentations
/ Topics: computational toxicology , modeling
Urban JD , Wikoff DS , Chappell GA, Harris C, Haws LC. 2020. Systematic evaluation of mechanistic data in assessing in utero exposures to trichloroethylene and development of congenital heart defects. Toxicology 436(30 April):152427; doi: 10.1016/j.tox.2020.152427 . PMID: 32145346.
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Publication: Manuscripts
/ Topics: trichloroethylene
Chappell GA, Thompson CM , Wolf JC, Cullen JM, Klaunig JE, Haws LC. 2020. Assessment of the mode of action underlying the effects of GenX in mouse liver and implications for assessing human health risks. Toxicol Pathol 48(3):494–508; doi: 10.1177/0192623320905803 . PMID: 32138627.
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