Tice RR, Bassan A, Amberg A, Anger LT, Beal MA, Bellion P, Benigni R, Birmingham J, Brigo A, Bringezu F, Ceriani L, Crooks I, Cross K, Elespuru R, Faulkner DM, Fortin MC, Fowler P, Frericks M, Greets HHJ, Jahnke GD, Jones DR, Krulak NL, Piparo EL, Lopez-Belmonte J, Luniwal A, Luu A, Madia F, Manganelli S, Manickam B, Mestres J, Mihalchik-Burhans AL , Neilson L, Pandiri A, Pavan M, Rider CV, Rooney JP, Trejo-Martin A, Wantanabe-Sailor KH, White AT, Wooley D, Myatt GJ. 2021. In silico approaches in carcinogenicity hazard assessment: Current status and future needs. Comp Toxicol 20:100191 (Special issue: The in silico toxicology protocols initiative).
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Publication: Manuscripts
/ Topics: Toxicology
Franke K , Payne L , Franzen A , Wikoff D , Henderson R . 2021. Cannabidiol literature scoping review protocol. Center for Open Science, OSFHOME (May 20).
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Publication: Manuscripts
/ Topics: Systematic Review
Wikoff D , Edwards S, Angrish M, Baumgartner, Bever R, Borghoff S , Chappell G, Chew R, Fitch S , Hench G, Hamernik K, Henderson D, Kirk A, Lea I , Mandel M, Payne L , Shapiro S, Urban J , Williams D, Markey K. Application of systematic methods to characterize thyroid adverse outcome pathways (AOPs). Presented at 10th annual meeting of American Society for Cellular and Computational Toxicology (virtual), October 2021.
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Publication: Abstracts and Presentations
/ Topics: Systematic Review , Toxicology
Thompson CM , Aardema MJ, Heintz MM , MacGregor JT, Young RR. 2021. A review of mammalian in vivo genotoxicity of hexavalent chromium: Implications for oral carcinogenicity risk assessment. Crit Rev Toxicol 51(2), https://doi.org/10.1080/10408444.2021.2000934 .
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Publication: Manuscripts
/ Topics: Cr(VI) MOA Study Manuscripts
Black MB, Andersen ME, Pendse SN, Borghoff SJ , Streicker M, McMullen PD. 2021. RNA-sequencing (transcriptomic) data collected in liver and lung of male and female B6C3F1 mice exposed to various dose levels of 4-methylimidazole for 2, 5, or 28 days. Data in Brief 38:107420. doi: 10.1016/j.dib.2021.107420. PMID: 34660856; PMCID: PMC8502903.
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Publication: Manuscripts
/ Topics: Toxicology
Palermo CM, Foreman JE, Wikoff DS , Lea I . 2021. Development of a putative adverse outcome pathway network for male rat reproductive tract abnormalities with specific considerations for the androgen sensitive window of development. Curr Res Toxicol 22:2:254–271. doi: 10.1016/j.crtox.2021.07.002. PMID: 34401750; PMCID: PMC8350458.
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Publication: Manuscripts
/ Topics: Toxicology
Gentry R, Rodricks J, Clewell H, Greene T, Chappell G, Lea I , Borghoff S , Yang C, Rathman J, Ribeiro JV, Hobocienski B, Mostrag A. 2021. RE: Response to the Office of Environmental Health Hazard Assessment on comments related to Gentry et al. (2021). Food Chem Toxicol 152:112202. doi: 10.1016/j.fct.2021.112202. Epub 2021 Apr 17. PMID: 33872725.
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Publication: Manuscripts
/ Topics: Toxicology
Gentry R, Greene T, Chappell G, Lea I , Borghoff S , Yang C, Rathman J, Ribeiro JV, Hobocienski B, Mostrag A, Rodricks J, Clewell H. 2021. Integration of evidence to evaluate the potential for neurobehavioral effects following exposure to USFDA-approved food colors. Food Chem Toxicol 151:112097. doi: 10.1016/j.fct.2021.112097. Epub 2021 Mar 4. PMID: 33677041.
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Publication: Manuscripts
/ Topics: Toxicology
Lea IA , Chappell GA, Wikoff DS . 2021. Overall lack of genotoxic activity among five common low- and no-calorie sweeteners: A contemporary review of the collective evidence. Mutat Res Genet Toxicol Environ Mutagen 868–869:503389. doi: 10.1016/j.mrgentox.2021.503389. PMID: 34454695.
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Publication: Manuscripts
/ Topics: Systematic Review , Toxicology
Wikoff D, Fitch S, Borghoff S. Case-study applications using evidence-based approaches to assess endocrine activity for risk assessment. Invited speaker (Wikoff): 61st Annual Meeting (virtual) of the Society for Birth Defects Research & Prevention, June 2021.
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Publication: Abstracts and Presentations
/ Topics: Toxicology
Wikoff D. The [acceptable daily intake] for low- and no-calorie sweeteners: Origin, interpretation, and application. Invited speaker: Continuing education webinar, Institute for the Advancement of Food and Nutrition Sciences, July 2021.
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Publication: Abstracts and Presentations
/ Topics: Toxicology
Fitch SE , Payne LE , van de Ligt JLG , Doepker C , Handu D, Cohen SM, Anyangwe N, Wikoff D . 2021. Use of acceptable daily intake (ADI) as a health-based benchmark in nutrition research studies that consider the safety of low-calorie sweeteners (LCS): A systematic map. BMC Public Health 21(1):956, doi: 10.1186/s12889-021-10934-2.
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Publication: Manuscripts
/ Topics: Systematic Review , Toxicology
Borghoff SJ , Fitch SE , Black MVB, McMullen PD, Andersen ME, Chappell GA. 2021. A systematic approach to evaluate plausible modes of [action] for mouse lung tumors in mice exposed to 4-methylimidozole. Regul Toxicol Pharmacol 124:104977; DOI: 10.1016/j.yrtph.2021.104977.
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Publication: Manuscripts
/ Topics: Systematic Review , Toxicology
Whaley P, Blaauboer BJ, Brozek J, Cohen Hubal EA, Hair K, Kacew S, Knudsen TB, Kwiatkowski CF, Mellor DT, Olshan AF, Page MJ, Rooney AA, Radke E, Shamseer L, Tsaioun K, Tugwell P, Wikoff D , Woodruff TJ. 2021. Improving the quality of toxicology and environmental health systematic reviews: What journal editors can do. ALTEX [Internet] .
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Publication: Manuscripts
/ Topics: Systematic Review
Proctor DM , Bhat V, Suh M , Reichert H , Jiang X , Thompson CM . 2021. Inhalation cancer risk assessment for environmental exposure to hexavalent chromium: Comparison of margin-of-exposure and linear extrapolation approaches. Regul Toxicol Pharmacol 124:104969, doi.org/10.1016/j.yrtph.2021.104969.
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Publication: Manuscripts
/ Topics: Hexavalent Chromium , Toxicology
de Vries RBM, Angrish M, Browne P, Brozek J, Rooney AA, Wikoff DS , Whaley P, Edwards SW, Morgan RL, Druwe IL, Hoffmann S, Hartung T, Thayer K, Avey MT, Beverly BEJ, Falavigna M, Gibbons C, Goyak K, Kraft A, Nampo F, Qaseem A, Sears M, Singh JA, Willett C, Yost EY, Schünemann H, Tsaioun K. 2021. Applying evidence-based methods to the development and use of adverse outcome pathways. ALTEX — Alternatives to Animal Experimentation, 38(2):336–347, doi: 10.14573/altex.2101211.
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Publication: Manuscripts
/ Topics: Systematic Review
Dirven H, Vist GE, Bandhakavi S, Mehta J, Fitch SE , Pound P, Ram R, Kincaid B, Leenaars CHC, Chen M, Wright RA, Tsaioun K. 2021. Performance of preclinical models in predicting drug-induced liver injury in humans: A systematic review. Nature, Scientific Reports; open access .
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Publication: Manuscripts
/ Topics: Systematic Review , Toxicology
Chappell GA, Heintz MM, Borghoff SJ, Doepker CL, Wikoff DS . 2021. Lack of potential carcinogenicity for steviol glycosides — Systematic evaluation and integration of mechanistic data into the totality of evidence. Food Chem Toxicol 150:112045.
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Publication: Manuscripts
/ Topics: Systematic Review , Toxicology
Felter SP, Zhang X, Thompson C . 2021. Butylated hydroxyanisole: Carcinogenic food additive to be avoided or harmless antioxidant important to protect food supply? Regul Toxicol Pharmacol 121:104887.
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Publication: Manuscripts
/ Topics: Toxicology
Wikoff DS , Urban JD , Ring C, Britt J , Fitch S , Haws LC . 2021. Development of a range of plausible non-cancer toxicity values for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) based on effects on sperm count: Application of systematic review methods and quantitative integration of dose response using meta-regression. Toxicol Sci 179(2):162-182, https://doi.org/10.1093/toxsci/kfaa171.
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Publication: Manuscripts
/ Topics: Systematic Review , Toxicology
Chappell GA, Heintz MM , Haws LC . 2021. Transcriptomic analyses of livers from mice exposed to 1,4-dioxane for up to 90 days to assess potential mode(s) of action underlying liver tumor development. Curr Res Toxicol 2:30–41.
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Publication: Manuscripts
/ Topics: Toxicology
Chappell GA, Wikoff DS , Thompson CM . 2021. Assessment of mechanistic data for hexavalent chromium-induced rodent intestinal cancer using the key characteristics of carcinogens. Toxicol Sci 180(1):38–50.
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