2025
Diemar MG, Giusti A, Michel-Caillet C, Leme DM, Wikoff D , Bloch D, Sass J, Beekmann K, et al. 2025. How to organize a successful toxicology workshop? A participant perspective on the Collaboration to Harmonise the Assessment of Next Generation Evidence (CHANGE) workshop in Oslo, 18-20 June 2024. Arch Toxicol; doi: 10.1007/s00204-025-04064-6 . Online ahead of print May 15, 2025. PMID: 40372420.
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Topics: chemical safety assessment , NAMs , regulations , risk assessment , safety , science policy , Toxicology
Crincoli CM, van de Ligt JLG, Eapen AK. Pavel AT, Hanlon PR, Almond-Abbate K, Haugabrooks E,… Henderson RG . 2025. A tool to support food substance safety evaluations in the United States. Regul Toxicol Pharmacol 105838; doi: 10.1016/j.yrtph.2025.105838 . Online ahead of print May 3, 2025. PMID: 40324559.
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Topics: food additives , food safety , Food science , GRAS , ingredient safety , risk assessment
Brorby G, Franzen A, Thompson C, Wikoff D , Doepker C. 2025. Human health risk assessment of three smoke flavoring primary products. Food Chem Toxicol 115490; doi: 10.1016/j.fct.2025.115490 . Online ahead of print May 2, 2025. PMID: 40320068.
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Topics: flavorings , food safety , Food science , genotoxicity , risk assessment , safety , Toxicology
Rogers JM, Heintz MM , Haws LC. 2025. Reproductive and developmental toxicity screen (OECD TG 421) and extended one generation reproductive toxicity study (OECD TG 443) of decahydronaphthalene in Sprague Dawley rats. Regul Toxicol Pharmacol 160(Aug):105829; doi: 10.1016/j.yrtph.2025.105829 . PMID: 40222475.
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Topics: adrenal hypertrophy , Decahydronaphthalene , industrial solvents , Toxicology
Heintz MM , Buerger AN, Haws LC, Cullen JM, East AW, Thompson CM . 2025. Comparison of phenotypic and transcriptomic profiles between HFPO-DA and prototypical PPARα , PPARγ , and cytotoxic agents in wild-type and Pparα -null mouse livers. Toxicol Sci kfaf049; doi: 10.1093/toxsci/kfaf049 . Online ahead of print 11 April 2025. PMID: 40216583.
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Topics: mode of action , Toxicology , transcriptomics
Wikoff DS, Vincent MJ, Heintz MM , Pastula ST, Reichert H, Klaren WD , Haws LC. 2025. Application of a quantitative uncertainty assessment to develop ranges of plausible toxicity values when using observational data in risk assessment: A case study examining associations between PFOA and PFOS exposures and vaccine response. Toxicol Sci 204(1):96-115; doi: 10.1093/toxsci/kfae152 . PMID: 39792025.
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Topics: PFAS , risk assessment , Systematic Review , Toxicology
Lea IA , Feifarek D, Mihalchik A, Heintz M , Haws L, Nyambego H, Goyak K, Palermo C, Borghoff SJ . 2025. Evaluation of the endocrine disrupting potential of Di-isodecyl phthalate. Curr Res Toxicol 8:100221; doi: 10.1016/j.crtox.2025.100221 . PMID: 40041033.
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Topics: phthalates
Borghoff SJ, Rivera B, Fitch S, Buerger AN, Choksi N, Franzen A, Vincent MJ, Covington T, Bus J, Rushton E, Lea IA . 2025. Systematic evaluation of the evidence base on methyl tert -butyl ether supporting a lack of concern for carcinogenic hazard in human based on animal cancer studies and mechanistic data. Curr Res Toxicol 8:100224; doi: 10.1016/j.crtox.2025.100224 . PMID: 40084233.
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Topics: Cancer , carcinogens , MTBE , risk assessment
Rogers JM , Buerger AN, Heintz MM, Palermo CM, Haws LC, Lea IA . 2025. Evaluation of a hypothesized Sertoli cell-based adverse outcome pathway for effects of diisononyl phthalate on the developing testis. Curr Res Toxicol 8:100219; doi: 10.1016/j.crtox.2025.100219 . PMID: 40123861.
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Topics: phthalates
Lea IA , Buerger AN, Feifarek D, Mihalchik A, Heintz MM, Haws LC, Nyambego H, Goyak K, Palermo C, Borghoff SJ . 2025. Evaluation of the endocrine disrupting potential of Di-isononyl phthalate. Curr Res Toxicol 8:100220; doi: 10.1016/j.crtox.2025.100220 . PMID: 40092461.
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