Evidenced-Based Toxicology

Systematic review protocol development and publication

  • PECO and PICO questions
  • Analytic framework
  • Conflict of interest
  • Expert review team selection and management
  • Research strategy design
  • Software selection tools

Systematic review implementation

  • Topic-specific search strategies
  • Inclusion and exclusion criteria
  • Study screening and data extraction
  • Evidence tables

Assessment of individual studies

  • Qualitative and quantitative study ranking
  • Risk of bias

Body-of-Evidence integration (weight of the evidence)

  • Synthesis of body of literature 
  • Confidence ratings
  • Meta-analysis
  • Dose-response assessment
  • Evaluation of lines of evidence 
  • Assessment of adverse outcome pathways
  • Causation analyses
  • Evidence-based conclusions
  • Reporting and publication