2026
Mihalchik AL , Roberts A, LaCombe J, Lloyd M, Doepker C , Eapen A. 2026. Evaluation of the safety and potential genotoxicity of a high-purity mogroside ingredient containing siamenoside I produced from a modified strain of Yarrowia lipolytica . Toxicol Rep 17(Dec):102297; doi: 10.1016/j.toxrep.2026.102297 . PMID: 42388455.
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Topics: food additives , food safety , Food science , safety assessment
Summan M, Doepker CL, Brorby GP . 2026. Safety evaluation of an aqueous root and leaf extract of Ashwagandha (Withania somnifera ). Phytother Res 40(8):5030-5047; doi: 10.1002/ptr.70314 . PMID: 41987003.
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Topics: Exposure Assessment , food safety , Food science , regulatory toxicology , safety assessment
Frankenfeld CL, Movva N, Hooda N, Gauthier J , Reichert H, Doepker C. 2026. Analysis of National Health and Nutrition Survey (NHANES): Nutrient, food, and beverage intake of glucagon-like peptide-1 receptor agonist users with type 2 diabetes, 2007-2020. J Nutr 156(8):101685; doi: 10.1016/j.tjnut.2026.101685 . PMID: 42331063.
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Topics: diabetes , NHANES , nutrition
Bearth A, Kopainsky B, Jones LB, Vist GE, Husoy T, Svendsen C, Whaley P,…, Wikoff D , et al. 2026. Modelling the regulatory toxicology system to promote the effective use of new approach methodologies: A system thinking approach. NAM J 2(Jul 24):100120; doi: 10.1016/j.namjnl.2026.100120 . PMID: 42569723
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Topics: chemical safety assessment , NAMs , regulatory toxicology , risk assessment
Mathisen GH, Whaley P, Kopainsky B, Ames HM, Hoffmann S, Husoy T, Jones L,…, Wikoff D , et al. 2026. Preparing for CHANGE: How systems thinking supports an effective transition from animal studies to NAMS. NAM J 2(July 20):100118; doi: 10.1016/j.namjnl.2026.100118 . PMID: 42564567.
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Topics: NAMs , regulatory toxicology
Kirman CR, Lipscomb JC, Rogers J , Schoeny RS, Seed JG, Sonawane BR, Hays SM. 2026. Evaluation of the modes of action for key noncancer effects of 1,3-Butadiene: Input from an independent expert panel to support derivation of data-derived extrapolation factors. Crit Rev Toxicol 56(4):252-278; doi: 10.1080/10408444.2026.2661191 . PMID: 42261678.
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Topics: chemical safety assessment , mode of action , risk assessment
Buerger AN, Thompson CM , Heintz MM , Maberti S, Palermo CM, Haws LC. 2026. Application of quantitative and qualitative uncertainty assessment risk management decision-making: A case study with diisononyl phthalate. Food Chem Toxicol 214(Aug):116110; doi: 10.1016/j.fct.2026116110 . PMID: 42035978.
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Topics: phthalates , risk analysis , risk assessment
Thompson CM , Heintz MM , Rogers SI, Vincent MJ, Haws LC. 2026. Integration of mechanistic and repeat dose toxicity data in the derivation of an oral reference dose for HFPO-DA. Toxicol Sci 209(5):kfag045; doi: 10.1093/toxsci/kfag045 . PMID: 41968070.
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Topics: PFAS , risk assessment
Buerger AN , Heintz MM , Haws LC , Thompson CM . 2026. Mode-of-action and human relevance assessment for diisononyl phthalate-induced liver tumor s in rodents. J Appl Toxicol ; doi : 10.1002/jat.70223 . Online ahead of print May 5 th . PMID: 42086044.
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Topics: carcinogens , mode of action , phthalates
Doepker C, Franzen A , Brorby G , Brown L, Choksi N, East A, Wikoff D . 2026. Smoke flavoring—A case study demonstrating the value of using benefit-risk analysis for foods (BRAFO) to provide transparency for risk management decisions. Regul Toxicol Pharmacol 167(May):106033; doi: 10.1016/j.yrtph.2026.106033 . PMID: 41577161.
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