Welsh BT , Todorovic J, Kirson D, Allen HM, Bayly MD, Mihic SJ. 2017. Disruption of a putative intersubunit electrostatic bond enhances agonist efficacy at the human α1 glycine receptor. Brain Res 1657:148-155.
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Mease K, Kimzey A, Lansita J . 2017. Biomarkers for nonclinical infusion reactions in marketed biotherapeutics and considerations for study design. Curr Opin Toxicol (4:1–15).
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Thompson CM , Wolf, JC, McCoy A, Suh M , Proctor DM , Kirman CR, Haws LC , Harris MA . 2017. Comparison of toxicity and recovery in the duodenum of B6C3F1 mice following treatment with intestinal carcinogens captan, folpet, and hexavalent chromium. Toxicol Pathol 45(8):1091–1101. DOI: 10.1177/019262331yy4324.
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Topics: Hexavalent Chromium , Toxicology
Rish W , Pfau EJ. 2017. Bounding analysis of drinking water health risks from a spill of hydraulic fracturing flowback water. Risk Analysis 38(4):724-754, DOI: 10.1111/risa.12884.
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2016
Thompson CM , Bichteler A, Rager JE, Suh M , Proctor DM , Haws LC , Harris MA . 2016. Comparison of in vivo genotoxic and carcinogenic potency to augment mode of action analysis: Case study with hexavalent chromium. Mut Res/Genetic Toxicol Environ Mutagen 800-801:28-34.
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Topics: Cr(VI) MOA Study Manuscripts , Hexavalent Chromium
Thompson CM , Rager JE, Suh M , Ring CL, Proctor DM , Haws LC , Fry RC, Harris MA . 2016. Transcriptomic responses in the oral cavity of F344 rats and B6C3F1 mice following exposure to Cr(VI): Implications for risk assessment. Environ Molec Mutagen 57:706-716.
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Topics: Chrome VI , Cr(VI) MOA Study Manuscripts , Hexavalent Chromium
De Flora S, Camoirano A, Micale RT, La Maestra S, Savarino V, Zentilin P, Marabotto E, Suh M , Proctor DM . 2016. Reduction of hexavalent chromium by fasted and fed human gastric fluid. I. Chemical reduction and mitigation of mutagenicity. Toxicol Appl Pharmaco l 306:113-119.
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Topics: Chrome VI , Cr(VI) MOA Study Manuscripts
Borghoff SJ , Ring C, Banton M, Leavens TL. 2016. Physiologically based pharmacokinetic model for ethyl tertiary-butyl ether and tertiary-butyl alcohol in rats: Contribution of binding to a2u-globulin in male rats and high-exposure nonlinear kinetics to toxicity and cancer outcomes. J Appl Toxicol , DOI 10.1002/jat.3412
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Topics: Toxicology
Thompson CM , Suh M , Mittal L , Wikoff D , Welsh B , Proctor DM . 2016. Development of linear and threshold no significant risk levels for inhalation exposure to titanium dioxide using systematic review and mode of action considerations. Regul Toxicol Pharmacol 80:60-70.
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Topics: Systematic Review
Suh M , Thompson CM , Brorby GP , Mittal L , Proctor DM . 2016. Inhalation cancer risk assessment of cobalt metal. Regul Toxicol Pharm 79(2016):74-82.
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Kirman CR, Suh M , Hays SM, Gürleyük H, Gerads R, De Flora S, Parker W, Lin S, Haws LC, Harris MA, Proctor DM . 2016. Reduction of hexavalent chromium by fasted and fed human gastric fluid. II. Ex vivo gastric reduction modeling. Toxicol Appl Pharmacol 306:120-133.
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Topics: Chrome VI , Cr(VI) MOA Study Manuscripts
Cullen JM, Ward JM, Thompson CM . 2016. Reevaluation and classification of duodenal lesions in B6C3F1 mice and F344 rats from 4 studies of hexavalent chromium in drinking water. Toxicologic Pathol 44(2):279-89.
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Topics: Cr(VI) MOA Study Manuscripts , Hexavalent Chromium
Wikoff DS, Britt JK . 2016. The role of systematic review in the practice of toxicology and risk assessment – An appreciation for the primary tool in evidence-based approaches. Toxicology: Open Access 2(110):1-4.
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Topics: Systematic Review , Toxicology
Wikoff DS, Rager JE, Haws LC, Borghoff SJ . 2016. A high dose mode of action for tetrabromobisphenol A-induced uterine adenocarcinomas in Wistar Han rats: A critical evaluation of key events in an adverse outcome pathway framework. Regul Toxicol Pharmacol 77:143-159. doi: 10.1016/j.yrtph.2016.01.018
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Hanlon P, Brorby GP , Krishan M. 2016. A risk-based strategy for evaluating mitigation options for processed-formed compounds in food: Workshop proceedings. Int J Toxicol 35(3):358–370.
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Schmitt D, Levy R, Carroll B. 2016. Toxicological evaluation of ß-caryophyllene oil: Subchronic toxicity in rats. Int J Toxicol 35(5):558–567.
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Topics: Toxicology
Borghoff SJ , Wikoff D , Harvey S , Haws L . 2016. Dose- and time-dependent changes in tissue levels of tetrabromobisphenol A (TBBPA) and its sulfate and glucuronide conjugates following repeated administration to female Wistar Han Rats. Toxicol Rep 3:190-201. doi:10.1016/j.toxrep.2016.01.007
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Doepker C , Lieberman HR, Smith AP, Peck JD, El-Sohemy A, Welsh BT . 2016. Caffeine: Friend or Foe? Annu Rev Food Sci Technol . DOI: 10.1146/annurev-food-041715-033243
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2015
Proctor DM , Suh M , Mittal L , Hirsch S, Salgado RV, Bartlett C, Van Landingham C, Rohr A, Crump K. 2015. Inhalation cancer risk assessment of hexavalent chromium based on updated mortality for Painesville chromate production workers. J Expo Sci Environ Epidemiol 26(2):224-231. doi: 10.1038/jes.2015.77.
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Topics: Chrome VI , Cr(VI) MOA Study Manuscripts , Hexavalent Chromium
James RC , Britt JK , Halmes NC, Guzelian PS. 2015. Evidence-based causation in toxicology: A 10-year retrospective. Hum Exp Toxicol 34(12):1245–1252.
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Lansita JA , Burke JM, Apgar JF, Mounho-Zamora B . 2015. An introduction to the regulatory and nonclinical aspects of the nonclinical development of antibody drug conjugates. Pharmceut Res 32(11):3584-3592. DOI 10.1007/s11095-015-1742-y
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Thompson CM , Wolf JC, Elbekai RH, Paranjpe MG, Seiter JM, Chappell MA, Tappero RV, Suh M , Proctor DM , Bichteler A, Haws LC , Harris MA . 2015. Duodenal crypt health following exposure to Cr(VI): Micronucleus scoring, γ-H2AX immunostaining, and synchrotron x-ray fluorescence microscopy. Mut Res 789–790:61–66.
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Topics: Chrome VI , Cr(VI) MOA Study Manuscripts , Hexavalent Chromium
Thompson CM , Young RR, Suh M , Dinesdurage HR, Elbekai RH, Harris MA , Rohr AC, Proctor DM . 2015. Assessment of the mutagenic potential of Cr(VI) in the oral mucosa of Big Blue® transgenic F344 rats. Environ Mol Mutagen 56:621-628.
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Topics: Chrome VI , Cr(VI) MOA Study Manuscripts , Hexavalent Chromium
Young RR, Thompson CM , Dinesdurage HR, Elbekai RH, Suh M , Rohr AC, Proctor DM. 2015. A robust method for assessing chemically induced mutagenic effects in the oral cavity of transgenic Big Blue® rats. Environ Mol Mutagen 56:629-636.
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Topics: Chrome VI , Cr(VI) MOA Study Manuscripts , Hexavalent Chromium
Borghoff SJ , Poet TS, Green S, Davis J, Hughes B, Mensing T, Sarang SS, Lynch AM, Hard GC. 2015. Methyl isobutyl ketone exposure-related increases in specific measures of α2u-globulin (α2u) nephropathy in male rats along with in vitro evidence of reversible protein binding. Toxicology 333(2015):1-13.
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Lansita JA, Mounho-Zamora B . 2015. The development of therapeutic monoclonal antibodies: Overview of the nonclinical safety assessment. Curr Pain Headache Rep 19(3):472.
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Urban JD , Carakostas MC, Taylor SL. 2015. Steviol glycoside safety: Are highly purified steviol glycoside sweeteners food allergens? Food Chem Toxicol 75: 71-78.
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Ramani T, Auletta CS, Weinstock D, Mounho-Zamora B , Ryan PC, Salcedo TW, Bannish G. 2015. Cytokines: The good, the bad, and the deadly. Int J Toxicol 34(4):355–365, DOI 10.1177/1091581815584918.
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Topics: Toxicology
2014
Wikoff D, Thompson C, Perry C, White M, Borghoff S, Fitzgerald L, Haws LC . 2014. Development of toxicity values and exposure estimates for tetrabromobisphenol A [TBBPA]: Application in a margin of exposure assessment. J Appl Toxicol 35(11):1292-1308. doi: 10.1002/jat.3132.
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Topics: Toxicology
Kerger BD, James RC , Galbraith DA. 2014. Tumors that mimic asbestos-related mesothelioma: Time to consider a genetics-based tumor registry? Frontiers in Genetics 5(151):1-14.
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Proctor DM, Suh M . Campleman SL, Thompson CM . 2014. Assessment of the mode of action for hexavalent chromium-induced lung cancer following inhalation exposures. Toxicology 325:160-179.
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Topics: Cr(VI) MOA Study Manuscripts , Hexavalent Chromium
Johnson GE, Soeteman-Hernandez, Gollapudi BB, Bodger OG, Dearfield KL, RH Heflich, Hixon JG, Lovell DP, MacGregor JT, Pottenger LH, Thompson CM , Abraham L , Thybaud V, Tanir JY, Zeiger E, van Benthem J, White PA. 2014. Derivation of point of departure (PoD) estimates in genetic toxicology studies and their potential applications in risk assessment. Environ Molec Mutagen 55(8):609-623. doi: 10.1002/em.21870/em.21870.
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Topics: Toxicology
Henderson R , Verougstraete V, Anderson K, Arbildua JJ, Brock TO, Brouwers T, Cappellini D, Delbeke K, Herting G, Hixon G , Wallinder IO, Rodriguez PH, Assche FV, Wilrich P, Oller AR. 2014. Interlaboratory validation of bioaccessibility testing for metals. Regul Toxicol Pharmacol 70(1):170-181. doi: 10.1016/j.yrtph.2014.06.02.
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Faber W, Kirkpatrick D, Coder P, Li P, Borghoff S , Banton M. 2014. Subchronic, reproductive, and maternal toxicity studies with tertiary butyl acetate (TBAC). Regul Toxicol Pharmacol 68:332-342.
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Topics: Toxicology
James RC , Britt J, Halmes N, Guzelian P. 2014. Comments on recent discussions providing differing causation methodologies. Hum Experim Toxicol 33(1):109-112.
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Juberg DR, Borghoff SJ , Becker RA, Casey W, Hartung T, Holsapple MP, Marty MS, Mihaich EM, Van Der Kraak G, Wade MG and others. 2014. t4 Workshop report — Lessons learned, challenges, and opportunities: The U.S. Endocrine Disruptor Screening Program. Altex 31(1):63-78.
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Song G, Darr DB, Santos CM, Ross M, Valdivia A, Jordan JL, Midkiff BR, Cohen S , Feinberg NN, Miller CR, Tarrant TK, Rogers AB, Dudley AC, Perou CM, Zamboni WC. 2014. Effects of tumor microenvironment heterogeneity on nanoparticle disposition and efficacy in breast cancer tumor models. Clin Cancer Res 20(23):6083–6095.
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Topics: Toxicology
Bhusari S, Malarkey DE, Hong HH, Wang Y, Masinde T, Nolan M, Hooth NJ, Lea IA , Vasconcelos D, Sills RC, Hoenerhoff MJ. 2014. Mutation spectra of Kras and Tp53 in urethral and lung neoplasms in B6C3F1 mice treated with 3,3′,4,4′-tetrachloroazobenzene. Toxicol Pathol 42(3):555–564.
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Topics: Toxicology
Suh M, Troese MJ, Hall DA, Yasso B, Yzenas JJ, Proctor DM . 2014. Evaluation of electric arc furnace-processed steel slag for dermal corrosion, irritation, and sensitization from dermal contact. J Appl Toxicol 34(12):1418-1425. DOI: 10.1002/jat.2974.
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Topics: Toxicology
Bunch AG, Perry CS, Abraham L, Wikoff DS, Tachovsky JA, Hixon JG, Urban JD, Harris MA, Haws LC . 2014. Evaluation of impact of shale gas operations in the Barnett Shale region on volatile organic compounds in air and potential human health risks. Sci Tot Environ 468-469(2014):832-842.
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Suh M, Abraham L, Hixon JG, Proctor D . 2014. The effects of perchlorate, nitrate, and thiocyanate on free thyroxine for potentially sensitive subpopulations of the 2001–2002 and 2007–2008 National Health and Nutrition Examination Surveys. J Expos Sci Epidemiol 24:579-587.
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Urban JD, Wikoff DS, Bunch ATG, Harris MA, Haws LC . 2014. A review of background dioxin concentrations in urban/suburban and rural soils across the United States: Implications for site assessments and the establishment of soil cleanup levels. Sci Tot Environ 466-467:586-597.
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Thompson CM , Kirman CR, Proctor DM , Haws LC , Suh M , Hays S, Hixon JG, Harris MA . 2014. A chronic oral reference dose for hexavalent chromium-induced intestinal cancer. J Appl Toxicol 34:525-536. doi: 10.1002/jat.2907.
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Topics: Hexavalent Chromium
Mahadevan B, Thorsrud BA, Brorby GP , Ferguson HE. 2014. A 3-week dietary safety study of octenyl succinic anhydride (OSA)-modified starch in neonatal farm piglets. Food Chem Toxicol 72:83-89.
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Suh M, Thompson C, Kirman C, Carakostas M, Haws LC, Harris M, Proctor D . 2014. High concentrations of hexavalent chromium in drinking water alter iron homeostasis in F344 rats and B6C3F1 mice. Food Chem Toxicol 65:381-388.
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Topics: Cr(VI) MOA Study Manuscripts , Hexavalent Chromium
2013
MacDonell MM, Haroun LA, Teuschler LK, Rice ER, Hertzberg RC, Butler JP, Chang Y, Clark S, Johns AP, Perry CS , Garcia SS, Jacobi JH, Scofield MA. 2013. Cumulative risk assessment toolbox: Methods and approaches for the practitioner. J Toxicol 2013:310904.
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Kirman CR, Aylward LL, Suh M , Harris MA , Thompson CM , Haws LC , Proctor DM , Lin SS, Parker W, Hays SM. 2013. Physiologically based pharmacokinetic model for humans orally exposed to chromium. Chem Biol Interact 204(1):13-27. doi:pii: S0009-2797(13)00082-3. 10.1016/j.cbi.2013.04.003.
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