Tice RR, Bassan A, Amberg A, Anger LT, Beal MA, Bellion P, Benigni R, Birmingham J, Brigo A, Bringezu F, Ceriani L, Crooks I, Cross K, Elespuru R, Faulkner DM, Fortin MC, Fowler P, Frericks M, Greets HHJ, Jahnke GD, Jones DR, Krulak NL, Piparo EL, Lopez-Belmonte J, Luniwal A, Luu A, Madia F, Manganelli S, Manickam B, Mestres J, Mihalchik-Burhans AL , Neilson L, Pandiri A, Pavan M, Rider CV, Rooney JP, Trejo-Martin A, Wantanabe-Sailor KH, White AT, Wooley D, Myatt GJ. 2021. In silico approaches in carcinogenicity hazard assessment: Current status and future needs. Comp Toxicol 20:100191 (Special issue: The in silico toxicology protocols initiative).
View Abstract
Topics: Toxicology
2021
Franke K , Payne L , Franzen A , Wikoff D , Henderson R . 2021. Cannabidiol literature scoping review protocol. Center for Open Science, OSFHOME (May 20).
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Topics: Systematic Review
Black MB, Andersen ME, Pendse SN, Borghoff SJ , Streicker M, McMullen PD. 2021. RNA-sequencing (transcriptomic) data collected in liver and lung of male and female B6C3F1 mice exposed to various dose levels of 4-methylimidazole for 2, 5, or 28 days. Data in Brief 38:107420. doi: 10.1016/j.dib.2021.107420. PMID: 34660856; PMCID: PMC8502903.
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Topics: Toxicology
Palermo CM, Foreman JE, Wikoff DS , Lea I . 2021. Development of a putative adverse outcome pathway network for male rat reproductive tract abnormalities with specific considerations for the androgen sensitive window of development. Curr Res Toxicol 22:2:254–271. doi: 10.1016/j.crtox.2021.07.002. PMID: 34401750; PMCID: PMC8350458.
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Topics: Toxicology
Gentry R, Rodricks J, Clewell H, Greene T, Chappell G , Lea I , Borghoff S , Yang C, Rathman J, Ribeiro JV, Hobocienski B, Mostrag A. 2021. RE: Response to the Office of Environmental Health Hazard Assessment on comments related to Gentry et al. (2021). Food Chem Toxicol 152:112202. doi: 10.1016/j.fct.2021.112202. Epub 2021 Apr 17. PMID: 33872725.
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Topics: Toxicology
Gentry R, Greene T, Chappell G , Lea I , Borghoff S , Yang C, Rathman J, Ribeiro JV, Hobocienski B, Mostrag A, Rodricks J, Clewell H. 2021. Integration of evidence to evaluate the potential for neurobehavioral effects following exposure to USFDA-approved food colors. Food Chem Toxicol 151:112097. doi: 10.1016/j.fct.2021.112097. Epub 2021 Mar 4. PMID: 33677041.
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Topics: Toxicology
Lea IA , Chappell GA , Wikoff DS . 2021. Overall lack of genotoxic activity among five common low- and no-calorie sweeteners: A contemporary review of the collective evidence. Mutat Res Genet Toxicol Environ Mutagen 868–869:503389. doi: 10.1016/j.mrgentox.2021.503389. PMID: 34454695.
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Topics: Systematic Review , Toxicology
Fitch SE , Payne LE , van de Ligt JLG , Doepker C , Handu D, Cohen SM, Anyangwe N, Wikoff D . 2021. Use of acceptable daily intake (ADI) as a health-based benchmark in nutrition research studies that consider the safety of low-calorie sweeteners (LCS): A systematic map. BMC Public Health 21(1):956, doi: 10.1186/s12889-021-10934-2.
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Topics: Systematic Review , Toxicology
Borghoff SJ , Fitch SE , Black MVB, McMullen PD, Andersen ME, Chappell GA . 2021. A systematic approach to evaluate plausible modes of [action] for mouse lung tumors in mice exposed to 4-methylimidozole. Regul Toxicol Pharmacol 124:104977; DOI: 10.1016/j.yrtph.2021.104977.
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Topics: Systematic Review , Toxicology
Whaley P, Blaauboer BJ, Brozek J, Cohen Hubal EA, Hair K, Kacew S, Knudsen TB, Kwiatkowski CF, Mellor DT, Olshan AF, Page MJ, Rooney AA, Radke E, Shamseer L, Tsaioun K, Tugwell P, Wikoff D , Woodruff TJ. 2021. Improving the quality of toxicology and environmental health systematic reviews: What journal editors can do. ALTEX [Internet] .
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Topics: Systematic Review
Proctor DM , Bhat V, Suh M , Reichert H , Jiang X , Thompson CM . 2021. Inhalation cancer risk assessment for environmental exposure to hexavalent chromium: Comparison of margin-of-exposure and linear extrapolation approaches. Regul Toxicol Pharmacol 124:104969, doi.org/10.1016/j.yrtph.2021.104969.
View Abstract
Topics: Hexavalent Chromium , Toxicology
de Vries RBM, Angrish M, Browne P, Brozek J, Rooney AA, Wikoff DS , Whaley P, Edwards SW, Morgan RL, Druwe IL, Hoffmann S, Hartung T, Thayer K, Avey MT, Beverly BEJ, Falavigna M, Gibbons C, Goyak K, Kraft A, Nampo F, Qaseem A, Sears M, Singh JA, Willett C, Yost EY, Schünemann H, Tsaioun K. 2021. Applying evidence-based methods to the development and use of adverse outcome pathways. ALTEX — Alternatives to Animal Experimentation, 38(2):336–347, doi: 10.14573/altex.2101211.
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Topics: Systematic Review
Saili KS, Antonijevic T , Zurlinden TJ, Shah I, Deisenroth C, Knudsen TB. 2020. Molecular characterization of a toxicological tipping point during human stem cell differentiation. Reprod Toxicol 91:1–13 (selected as journal’s best paper of 2020 ).
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Topics: Toxicology
Dirven H, Vist GE, Bandhakavi S, Mehta J, Fitch SE , Pound P, Ram R, Kincaid B, Leenaars CHC, Chen M, Wright RA, Tsaioun K. 2021. Performance of preclinical models in predicting drug-induced liver injury in humans: A systematic review. Nature, Scientific Reports; open access .
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Topics: Systematic Review , Toxicology
Chappell GA, Heintz MM, Borghoff SJ, Doepker CL, Wikoff DS . 2021. Lack of potential carcinogenicity for steviol glycosides — Systematic evaluation and integration of mechanistic data into the totality of evidence. Food Chem Toxicol 150:112045.
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Topics: Systematic Review , Toxicology
Felter SP, Zhang X, Thompson C . 2021. Butylated hydroxyanisole: Carcinogenic food additive to be avoided or harmless antioxidant important to protect food supply? Regul Toxicol Pharmacol 121:104887.
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Topics: Toxicology
Thompson CM , Gentry R, Fitch S , Lu K, Clewell HJ. 2020. An updated mode of action and human relevance framework evaluation for formaldehyde-related nasal tumors. Crit Rev Toxicol 50(10):919–952, DOI: 10.1080/10408444.2020.1854679.
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Topics: Toxicology
Gentry R, Thompson CM , Franzen A , Salley J, Albertini R, Lu K, Greene T. 2020. Using mechanistic information to support evidence integration and synthesis: A case study with inhaled formaldehyde and leukemia. Crit Rev Toxicol 50(10):885–918, DOI: 10.1080/10408444.2020.1854678.
View Abstract
Topics: Toxicology
Wikoff DS , Urban JD , Ring C, Britt J , Fitch S , Haws LC . 2021. Development of a range of plausible non-cancer toxicity values for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) based on effects on sperm count: Application of systematic review methods and quantitative integration of dose response using meta-regression. Toxicol Sci 179(2):162-182, https://doi.org/10.1093/toxsci/kfaa171.
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Topics: Systematic Review , Toxicology
Chappell GA , Heintz MM , Haws LC . 2021. Transcriptomic analyses of livers from mice exposed to 1,4-dioxane for up to 90 days to assess potential mode(s) of action underlying liver tumor development. Curr Res Toxicol 2:30–41.
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Topics: Toxicology
Chappell GA , Wikoff DS , Thompson CM . 2021. Assessment of mechanistic data for hexavalent chromium-induced rodent intestinal cancer using the key characteristics of carcinogens. Toxicol Sci 180(1):38–50.
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Topics: Toxicology
2020
Eichenbaum G, Yang K, Gebremichael Y, Howell BA, Murray FJ, Jacobson-Kram D, Jaeschke H, Kuffner E, Gelotte CK, Lai JCK, Wikoff D , Atillasoy E. 2020. Application of the DILIsym® Quantitative Systems Toxicology drug-induced liver injury model to evaluate the carcinogenic hazard potential of acetaminophen. Regul Toxicol Pharmacol 118:104788.
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Topics: Toxicology
Whaley P, Aiassa E, Beausoleil C, Beronius A, Bilotta, G, Boobis A, de Vries R, Hanberg A, Hoffman S, Hunt N, Kwiatkowski CF, Lam J, Lipworth S, Martin O, Randall, N, Rhomberg L, Rooney AA, Holger J, Schünemann HJ, Wikoff D , Wolffe T, Halsall C. 2020. Recommendations for the conduct of systematic reviews in toxicology and environmental health research (COSTER). Environ Int 143:105926.
Topics: Systematic Review
Chappell GA , Wikoff DS , Doepker CL , Borghoff SJ . 2020. Lack of potential carcinogenicity for acesulfame potassium — Systematic evaluation and integration of mechanistic data into the totality of the evidence. Food Chem Toxicol 141:111375 [open access ].
View Abstract
Topics: Systematic Review
Chappell GA , Britt JK , Borghoff, SJ . 2020. Systematic assessment of mechanistic data for FDA-certified food colors and neurodevelopmental processes. Food Chem Toxicol 140:111310 [open access] .
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Topics: Systematic Review
Pham LL, Borghoff SJ , Thompson CM . 2020. Comparison of threshold of toxicological concern (TTC) values to oral reference dose (RfD) values. Regul Toxicol Pharmacol 113:104651 [open access ].
View Abstract
Topics: Toxicology
Lea IA , Jackson MA, Li X, Bailey S, Peddada SD, Dunnick JK. 2007. Genetic pathways and mutation profiles of human cancers: Site- and exposure-specific patterns. Carcinogenesis 28:1851–1858.
Topics: Toxicology
Wikoff DS , Bennett DC, Brorby GP , Franke KS. 2020. Evaluation of potential human health risk associated with consumption of edible products from livestock fed ration supplemented with Red Lake Diatomaceous Earth. Food Addit Contam Part A ; DOI: 10.1080/19440049.2020.1727963.
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Topics: Toxicology
2019
Yoon M, Ring C, Van Landingham CB, Suh M , Song G, Antonijevic T , Gentry PR, Taylor MD, Keen AM, Andersen ME, Clewell JH. 2019. Assessing children’s exposure to manganese in drinking water using a PBPK model. Toxicol Appl Pharmacol 380:114695
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Topics: Toxicology
Wikoff D , Haws L Ring C, Budinsky R. 2019. Application of qualitative and quantitative uncertainty assessment tools in developing ranges of plausible toxicity values for 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin. J Appl Toxicol , doi: 10.1002/jat.3814, open access.
View Abstract
Topics: Toxicology
Rager JE, Suh M , Chappell G , Thompson CM , Proctor DM . 2019. Review of transcriptomic responses to hexavalent chromium exposure in lung cells supports a role of epigenetic mediators in carcinogenesis. Toxicol Lett 305:40–50.
View Abstract
Topics: Chrome VI
Suh M , Wikoff D , Lipworth L, Goodman M, Fitch S , Mittal L , Ring C, Proctor D . 2019. Hexavalent chromium and stomach cancer: A systematic review and meta-analysis. Crit Rev Toxicol [ePub ahead of print]: doi: 10.1080/10408444.2019.1578730.
View Abstract
Topics: Hexavalent Chromium , Systematic Review
Wikoff DS , Rager JE, Chappell GA , Fitch S , Haws L , Borghoff SJ . 2019. A framework for systematic evaluation and quantitative integration of mechanistic data in assessments of potential human carcinogens. Toxicol Sci 167(2):322-335.
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2018
Tsaioun K, Dirven H, Beck Færden K, Wikoff D , Ram R, Kleinstreuer N, McCormack A, Wright R, Vist GE, Fitch S . 2018. Systematic reviews of the hepatotoxic effects of specified compounds/drugs as observed in humans and experimental animals (rats, mice, dogs and non-human primates). PROSPERO CRD42018112353 .
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Topics: Toxicology
Borghoff SJ, Fitch S , Rager JE, Huggett D. 2018. A hypothesis-driven weight-of-evidence analysis to evaluate potential endocrine activity of perfluorohexanoic acid. Regul Toxicol Pharmacol 99:168–181.
View Abstract
Topics: PFAS , Toxicology
Moffat I, Martinova N, Seidel C, Thompson CM. 2018. Hexavalent chromium in drinking water. Journal AWWA 110:5.
View Abstract
Topics: Chrome VI
Wikoff DS , Miller GW. 2018. Systematic reviews in toxicology (Editorial). Toxicol Sci 163(2):335–337.
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Topics: Systematic Review , Toxicology
Thompson CT , Suh M , Chappell G , Borghoff S , Ellis-Hutchings, R, Wiench, K, Finch, L, Proctor, DM . 2018. Assessment of the mode of action underlying development of forestomach tumors in rodents following oral exposure to ethyl acrylate and relevance to humans. Regul Toxicol Pharmacol 96:178–189 doi: 10.1016/j.yrtph.2018.05.006.
Topics: PFAS , Toxicology
Suh M , Proctor DM , Chappell G , Rager JE , Thompson CM , Borghoff S , Finch L, Ellis-Hutchings R, Wiench K. 2018. A review of the genotoxic, mutagenic, and carcinogenic potentials of several lower acrylates. Toxicology 402-403:50-67, doi: 10.1016/j.tox.2018.04.006.
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Topics: Toxicology
Proctor DM , Suh M , Chappell G , Borghoff SJ , Thompson CM , Wiench K, Finch L, Ellis-Hutchings R. 2018. An adverse outcome pathway (AOP) for forestomach tumors induced by non-genotoxic initiating events. Regul Toxicol Pharmacol , 96:30-40, doi: 10.1016/j.yrtph.2018.04.016.
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Topics: Toxicology
Thompson CM , Kirman CR, Hays SM, Suh M , Harvey SE, Proctor DM , Rager JE , Haws LC , Harris MA . 2018. Integration of mechanistic and pharmacokinetic information to derive oral reference dose and margin-of-exposure values for hexavalent chromium. J Appl Toxicol 38:351–365. doi: 10.1002/jat.3545.
View Abstract
Topics: Hexavalent Chromium
Wikoff D, Urban JD, Harvey S, Haws LC . 2018. Role of risk of bias in systematic review for chemical risk assessment: A case study in understanding the relationship between congenital heart defects and exposures to trichloroethylene. Int J Toxicol , DOI: 0.1177/1091581818754330.
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Topics: Systematic Review , Toxicology
2017
Lansita J , Mease KM , Qiu H, Yednock T, Sankaranarayanan S, Kramer S. 2017. Nonclinical development of ANX005: A humanized anti-Clq antibody for treatment of autoimmune and neurodegenerative diseases. Int J Toxicol 1-14. DOI: 10.1177/1091581817740873.
View Abstract
Rager JE, Auerbach SS, Chappell GA , Martin E, Thompson C , Fry RC. 2017. Benchmark dose modeling estimates of the concentrations of inorganic arsenic that induce changes to the neonatal transcriptome, proteome, and epigenome in a pregnancy cohort. Chem Res Toxicol 30(10):1911-1920; DOI: 10.1021/acs.chemrestox.7b00221.
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Topics: Toxicology
Thompson CM, Suh M, Proctor DM, Haws LC, Harris MA . 2017. Ten factors for considering the mode of action of Cr(VI)-induced gastrointestinal tumors in rodents. Mutation Res 823:45-57.
View Abstract
Topics: Chrome VI , Hexavalent Chromium
Thompson CM , Young RR, Dinesdurage H, Suh M , Harris MA , Rohr AC, Proctor DM . 2017. Assessment of the mutagenic potential of hexavalent chromium in the duodenum of Big Blue® rats. Toxicol Appl Pharmacol 330(1):48-52.
View Abstract
Topics: Cr(VI) MOA Study Manuscripts , Hexavalent Chromium
Chappell GA, Rager JE. 2017. Epigenetics in chemical-induced genotoxic carcinogenesis. Current Opinion Toxicol 6:10-17.
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Bichteler A, Wikoff DS, Loko F, Harris MA . 2017. Estimating serum concentrations of dioxin-like compounds in the U.S. population effective 2005-2006 and 2007-2008: A multiple imputation and trending approach incorporating NHANES pooled sample data. Environ Int 105(2017):112-125.
View Abstract
Topics: Toxicology
Hoffmann S, de Vries RB, Stephens ML, Beck NB, Dirven HAAM, Fowle III JR, Goodman JE, Hartung T, Kimber I, Lalu MM, Thayer K, Whaley P, Wikoff D , Tsaioun K. 2017. A primer on systematic reviews in toxicology. Arch Toxicol DOI: 10.1007/s00204-017-1980-3.
View Abstract
Topics: Systematic Review
Rager JE, Ring CL, Fry RC, Suh M, Proctor DM, Haws L, Harris MA, Thompson CM . 2017. High-throughput screening data interpretation in the context of in vivo transcriptomic responses to oral Cr(VI) exposure. Toxicol Sci 158(1):199–212. https://doi.org/10.1093/toxsci/kfx085
View Abstract
Topics: Chrome VI , Cr(VI) MOA Study Manuscripts
Wikoff D, Welsh BT, Henderson R, Brorby GP, Britt J , Myers E, Goldberger J, Lieberman HR, O’Brian C, Peck J, Tenebein M, Weaver C, Harvey S, Urban J, Doepker C . 2017. Systematic review of the potential adverse effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children. Food Chem Toxicol 109(Pt1):585-648. https://doi.org/10.1016/j.fct.2017.04.002.
View Abstract
Topics: Systematic Review
Kirman CR, Suh M, Proctor DM , Hays SM. 2017. Improved physiologically based pharmacokinetic model for oral exposures to chromium in mice, rats, and humans to address temporal variation and sensitive populations. Toxicol Appl Pharmacol 325:9-17.
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Topics: Cr(VI) MOA Study Manuscripts , Hexavalent Chromium , Toxicology
Lea IA , Gong H, Paleja A, Rashid, A, Foster J. 2017. CEBS: A comprehensive annotated database of toxicological data. Nucleic Acids Res 45(D1):D964–D971.
View Abstract
Topics: Toxicology
Jackson MA, Yang L, Lea I , Rashid A, Kuo B, Williams A, Lyn Yauk C, Fostel J. 2017. The TGx-28 65 biomarker online application for analysis of transcriptomics data to identify DNA damage-inducing chemicals in human cell cultures. Environ Mol Mutagen 58(7):529–535.
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Topics: Toxicology
Mease K, Kimzey A, Lansita J . 2017. Biomarkers for nonclinical infusion reactions in marketed biotherapeutics and considerations for study design. Curr Opin Toxicol (4:1–15).
View Abstract
Thompson CM , Wolf, JC, McCoy A, Suh M , Proctor DM , Kirman CR, Haws LC , Harris MA . 2017. Comparison of toxicity and recovery in the duodenum of B6C3F1 mice following treatment with intestinal carcinogens captan, folpet, and hexavalent chromium. Toxicol Pathol 45(8):1091–1101. DOI: 10.1177/019262331yy4324.
View Abstract
Topics: Hexavalent Chromium , Toxicology
Rish W , Pfau EJ. 2017. Bounding analysis of drinking water health risks from a spill of hydraulic fracturing flowback water. Risk Analysis 38(4):724-754, DOI: 10.1111/risa.12884.
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2016
Thompson CM , Bichteler A, Rager JE, Suh M , Proctor DM , Haws LC , Harris MA . 2016. Comparison of in vivo genotoxic and carcinogenic potency to augment mode of action analysis: Case study with hexavalent chromium. Mut Res/Genetic Toxicol Environ Mutagen 800-801:28-34.
View Abstract
Topics: Cr(VI) MOA Study Manuscripts , Hexavalent Chromium
Thompson CM , Rager JE, Suh M , Ring CL, Proctor DM , Haws LC , Fry RC, Harris MA . 2016. Transcriptomic responses in the oral cavity of F344 rats and B6C3F1 mice following exposure to Cr(VI): Implications for risk assessment. Environ Molec Mutagen 57:706-716.
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Topics: Chrome VI , Cr(VI) MOA Study Manuscripts , Hexavalent Chromium
De Flora S, Camoirano A, Micale RT, La Maestra S, Savarino V, Zentilin P, Marabotto E, Suh M , Proctor DM . 2016. Reduction of hexavalent chromium by fasted and fed human gastric fluid. I. Chemical reduction and mitigation of mutagenicity. Toxicol Appl Pharmaco l 306:113-119.
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Topics: Chrome VI , Cr(VI) MOA Study Manuscripts
Borghoff SJ , Ring C, Banton M, Leavens TL. 2016. Physiologically based pharmacokinetic model for ethyl tertiary-butyl ether and tertiary-butyl alcohol in rats: Contribution of binding to a2u-globulin in male rats and high-exposure nonlinear kinetics to toxicity and cancer outcomes. J Appl Toxicol , DOI 10.1002/jat.3412
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Topics: Toxicology
Thompson CM , Suh M , Mittal L , Wikoff D , Welsh B, Proctor DM . 2016. Development of linear and threshold no significant risk levels for inhalation exposure to titanium dioxide using systematic review and mode of action considerations. Regul Toxicol Pharmacol 80:60-70.
View Abstract
Topics: Systematic Review
Suh M , Thompson CM , Brorby GP , Mittal L , Proctor DM . 2016. Inhalation cancer risk assessment of cobalt metal. Regul Toxicol Pharm 79(2016):74-82.
View Abstract
Kirman CR, Suh M , Hays SM, Gürleyük H, Gerads R, De Flora S, Parker W, Lin S, Haws LC, Harris MA, Proctor DM . 2016. Reduction of hexavalent chromium by fasted and fed human gastric fluid. II. Ex vivo gastric reduction modeling. Toxicol Appl Pharmacol 306:120-133.
View Abstract
Topics: Chrome VI , Cr(VI) MOA Study Manuscripts
Cullen JM, Ward JM, Thompson CM . 2016. Reevaluation and classification of duodenal lesions in B6C3F1 mice and F344 rats from 4 studies of hexavalent chromium in drinking water. Toxicologic Pathol 44(2):279-89.
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Topics: Cr(VI) MOA Study Manuscripts , Hexavalent Chromium
Wikoff DS, Britt JK . 2016. The role of systematic review in the practice of toxicology and risk assessment – An appreciation for the primary tool in evidence-based approaches. Toxicology: Open Access 2(110):1-4.
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Topics: Systematic Review , Toxicology
Wikoff DS, Rager JE, Haws LC, Borghoff SJ . 2016. A high dose mode of action for tetrabromobisphenol A-induced uterine adenocarcinomas in Wistar Han rats: A critical evaluation of key events in an adverse outcome pathway framework. Regul Toxicol Pharmacol 77:143-159. doi: 10.1016/j.yrtph.2016.01.018
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Hanlon P, Brorby GP , Krishan M. 2016. A risk-based strategy for evaluating mitigation options for processed-formed compounds in food: Workshop proceedings. Int J Toxicol 35(3):358–370.
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Schmitt D, Levy R, Carroll B. 2016. Toxicological evaluation of ß-caryophyllene oil: Subchronic toxicity in rats. Int J Toxicol 35(5):558–567.
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Topics: Toxicology
Borghoff SJ , Wikoff D , Harvey S , Haws L . 2016. Dose- and time-dependent changes in tissue levels of tetrabromobisphenol A (TBBPA) and its sulfate and glucuronide conjugates following repeated administration to female Wistar Han Rats. Toxicol Rep 3:190-201. doi:10.1016/j.toxrep.2016.01.007
View Abstract
Doepker C , Lieberman HR, Smith AP, Peck JD, El-Sohemy A, Welsh BT. 2016. Caffeine: Friend or Foe? Annu Rev Food Sci Technol . DOI: 10.1146/annurev-food-041715-033243
View Abstract
2015
Proctor DM , Suh M , Mittal L , Hirsch S, Salgado RV, Bartlett C, Van Landingham C, Rohr A, Crump K. 2015. Inhalation cancer risk assessment of hexavalent chromium based on updated mortality for Painesville chromate production workers. J Expo Sci Environ Epidemiol 26(2):224-231. doi: 10.1038/jes.2015.77.
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Topics: Chrome VI , Cr(VI) MOA Study Manuscripts , Hexavalent Chromium
James RC , Britt JK , Halmes NC, Guzelian PS. 2015. Evidence-based causation in toxicology: A 10-year retrospective. Hum Exp Toxicol 34(12):1245–1252.
View Abstract
Lansita JA , Burke JM, Apgar JF, Mounho-Zamora B . 2015. An introduction to the regulatory and nonclinical aspects of the nonclinical development of antibody drug conjugates. Pharmceut Res 32(11):3584-3592. DOI 10.1007/s11095-015-1742-y
View Abstract
Thompson CM , Wolf JC, Elbekai RH, Paranjpe MG, Seiter JM, Chappell MA, Tappero RV, Suh M , Proctor DM , Bichteler A, Haws LC , Harris MA . 2015. Duodenal crypt health following exposure to Cr(VI): Micronucleus scoring, γ-H2AX immunostaining, and synchrotron x-ray fluorescence microscopy. Mut Res 789–790:61–66.
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Topics: Chrome VI , Cr(VI) MOA Study Manuscripts , Hexavalent Chromium
Thompson CM , Young RR, Suh M , Dinesdurage HR, Elbekai RH, Harris MA , Rohr AC, Proctor DM . 2015. Assessment of the mutagenic potential of Cr(VI) in the oral mucosa of Big Blue® transgenic F344 rats. Environ Mol Mutagen 56:621-628.
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Topics: Chrome VI , Cr(VI) MOA Study Manuscripts , Hexavalent Chromium
Young RR, Thompson CM , Dinesdurage HR, Elbekai RH, Suh M , Rohr AC, Proctor DM. 2015. A robust method for assessing chemically induced mutagenic effects in the oral cavity of transgenic Big Blue® rats. Environ Mol Mutagen 56:629-636.
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Topics: Chrome VI , Cr(VI) MOA Study Manuscripts , Hexavalent Chromium
Borghoff SJ , Poet TS, Green S, Davis J, Hughes B, Mensing T, Sarang SS, Lynch AM, Hard GC. 2015. Methyl isobutyl ketone exposure-related increases in specific measures of α2u-globulin (α2u) nephropathy in male rats along with in vitro evidence of reversible protein binding. Toxicology 333(2015):1-13.
View Abstract
Lansita JA, Mounho-Zamora B . 2015. The development of therapeutic monoclonal antibodies: Overview of the nonclinical safety assessment. Curr Pain Headache Rep 19(3):472.
View Abstract
Urban JD , Carakostas MC, Taylor SL. 2015. Steviol glycoside safety: Are highly purified steviol glycoside sweeteners food allergens? Food Chem Toxicol 75: 71-78.
View Abstract
Ramani T, Auletta CS, Weinstock D, Mounho-Zamora B , Ryan PC, Salcedo TW, Bannish G. 2015. Cytokines: The good, the bad, and the deadly. Int J Toxicol 34(4):355–365, DOI 10.1177/1091581815584918.
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