Publications

Buerger AN, Heintz MM, Haws LC, Thompson CM. 2026. Mode-of-action and human relevance assessment for diisononyl phthalate-induced liver tumors in rodents. J Appl Toxicol 46(12):4264-4287; doi: 10.1002/jat.70223. PMID: 42086044. 

Schaefer HR, Frankenfeld CL, Wikoff D. 2026. Low- and no-calorie sweeteners lack shared target organs or modes of action required for cumulative risk assessment. Food Chem Toxicol 218(Dec):116424; doi: 10.1016/j.fct.2026.116424. PMID: 42829191. 

Mihalchik AL, Roberts A, LaCombe J, Lloyd M, Doepker C, Eapen A. 2026. Evaluation of the safety and potential genotoxicity of a high-purity mogroside ingredient containing siamenoside I produced from a modified strain of Yarrowia lipolytica. Toxicol Rep 17(Dec):102297; doi: 10.1016/j.toxrep.2026.102297. PMID: 42388455.

Patlewicz GY, Mihalchik AL. 2026. Revisiting the Threshold of Toxicological Concern: A computational framework for structural classification, cross-scheme comparison and opportunities for refinement. Comput Toxicol 39(Sept):100443; doi: 10.1016/j.comtox.2026.100443.

Summan M, Doepker CL, Brorby GP. 2026. Safety evaluation of an aqueous root and leaf extract of Ashwagandha (Withania somnifera). Phytother Res 40(8):5030-5047; doi: 10.1002/ptr.70314. PMID: 41987003.

Frankenfeld CL, Movva N, Hooda N, Gauthier J, Reichert H, Doepker C. 2026. Analysis of National Health and Nutrition Survey (NHANES): Nutrient, food, and beverage intake of glucagon-like peptide-1 receptor agonist users with type 2 diabetes, 2007-2020. J Nutr 156(8):101685; doi: 10.1016/j.tjnut.2026.101685. PMID: 42331063.

Bearth A, Kopainsky B, Jones LB, Vist GE, Husoy T, Svendsen C, Whaley P,…, Wikoff D, et al. 2026. Modelling the regulatory toxicology system to promote the effective use of new approach methodologies: A system thinking approach. NAM J 2(Jul 24):100120; doi: 10.1016/j.namjnl.2026.100120. PMID: 42569723

Mathisen GH, Whaley P, Kopainsky B, Ames HM, Hoffmann S, Husoy T, Jones L,…, Wikoff D, et al. 2026. Preparing for CHANGE: How systems thinking supports an effective transition from animal studies to NAMS. NAM J 2(July 20):100118; doi: 10.1016/j.namjnl.2026.100118. PMID: 42564567.

Patlewicz GY, Mihalchik AL, East A, Borghoff SJ, Thompson CM. 2026. Investigating the feasibility of deriving new environmentally relevant thresholds of Toxicological Concern (TTCs) from estimated chronic human equivalent benchmark dose (eBMD_HED) values. Comput Toxicol 38(June):100417; doi: 10.1016/j.comtox.2026.100417.

Kirman CR, Lipscomb JC, Rogers J, Schoeny RS, Seed JG, Sonawane BR, Hays SM. 2026. Evaluation of the modes of action for key noncancer effects of 1,3-Butadiene: Input from an independent expert panel to support derivation of data-derived extrapolation factors. Crit Rev Toxicol 56(4):252-278; doi: 10.1080/10408444.2026.2661191. PMID: 42261678.