Biological Response and Pathway-Based Toxicology

Frameworks for incorporation of new-approach method (NAM) testing strategies

Adverse Outcome Pathway (AOP) development and application to support:

  • Fit-for-purpose in vitro assay design
  • Mode-of-action identification

Computational toxicology

  • Integration of in vivo and in vitro toxicity data using in silico models 
  • Bioinformatics, including -omics data
  • QSAR
  • Development of custom structure activity and machine learning models
  • Pathway-based computational systems biology models
  • Dose-response modeling

Tiered testing strategies

  • Interpretation of high-throughput screening (HTS) data
    • Chemical prioritization
    • Margin of exposure
  • Organotypic in vitro models
    • Dose-response analysis
    • Defining a region of safety for chemical exposure
  • Targeted in vivo models
    • Validation and ground-truthing of in vitro assay and in silico predictions

Supporting risk-based decisions

  • Mode of action
  • Point of departure