Publication Topic

Choksi N, McMillan D, Schmitt D, Doepker C, Henderson RG. 2025. Demonstration of safety for rice bran wax and sunflower wax based on bridging to other naturally derived waxes used in food. Regul Toxicol Pharmacol 105990; doi: 10.1016/j.yrtph.2025.105990. PMID: 41248699. Advance online publication November 15, 2025.

 Klaren WD, Rivera BN, Sheppard AM, Franke K, Wikoff DS. 2025. Approach for systematically assessing study reliability and relevance in evaluations of monosodium glutamate safety. Curr Res Toxicol 9(Sep):100256; doi: 10.1016/j.crtox.2025.100256. PMID: 41030520.

Brorby G, Franzen A, Thompson C, Wikoff D, Doepker C. 2025. Human health risk assessment of three smoke flavoring primary products. Food Chem Toxicol 202(Aug):115490; doi: 10.1016/j.fct.2025.115490. PMID: 40320068.

Crincoli CM, van de Ligt JLG, Eapen AK. Pavel AT, Hanlon PR, Almond-Abbate K, Haugabrooks E,… Henderson RG. 2025. A tool to support food substance safety evaluations in the United States. Regul Toxicol Pharmacol 161(Sept):105838; doi: 10.1016/j.yrtph.2025.105838. PMID: 40324559.

Franzen AC, Thompson CM, Brorby GP, Wikoff DS, Ilkbahar Z, Doepker C. Risk assessment of three smoke flavoring primary products currently under re-evaluation by EFSA. Poster presented at Society of Toxicology 62^nd Annual Meeting, Nashville, TN, March 2023.

Borghoff SJ, Cohen SS, Jiang X, Lea IA, Klaren WD, Chappell GA, Britt JK, Rivera BN, Choksi NY, Wikoff DS. 2023. Updated systematic assessment of human, animal and mechanistic evidence demonstrates lack of human carcinogenicity with consumption of aspartame. Food Chem Toxicol 172(Feb):113549; doi: 10.1016/j.fct.2022.113549. PMID: 36493943.

Lea IA, Chappell GA, Wikoff DS. 2021. Overall lack of genotoxic activity among five common low- and no-calorie sweeteners: A contemporary review of the collective evidence. Mutat Res Genet Toxicol Environ Mutagen 868–869(Aug-Sept):503389; doi: 10.1016/j.mrgentox.2021.503389. PMID: 34454695.

Gentry R, Greene T, Chappell G, Lea I, Borghoff S, Yang C, Rathman J, Ribeiro JV, Hobocienski B, Mostrag A, Rodricks J, Clewell H. 2021. Integration of evidence to evaluate the potential for neurobehavioral effects following exposure to USFDA-approved food colors. Food Chem Toxicol 151(May):112097; doi: 10.1016/j.fct.2021.112097. PMID: 33677041.

Wikoff D. The [acceptable daily intake] for low- and no-calorie sweeteners: Origin, interpretation, and application. Invited speaker: Continuing education webinar, Institute for the Advancement of Food and Nutrition Sciences, July 2021.

Wikoff DS, Chappell GA, Fitch S, Doepker CL, Borghoff SJ. 2020. Lack of potential carcinogenicity for aspartame – Systematic evaluation and integration of mechanistic data into the totality of the evidence. Food Chem Toxicol 135(Jan):110866; doi: 10.1016/j.fct.2019.110866.