2026
Kennedy SB, Heintz MM , Brown L, Fender CL, Hecker M, Hughes SA, Naile J, DeLeo P. Defining the domain of applicability: A case study to increase confidence in toxicogenomic tools for ecological risk assessment. Poster 1.03.P-Tu032 , SETAC Europe 36th Annual Meeting, Maastricht, The Netherlands, May 19, 2026.
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Publication: Abstracts and Presentations
Heintz MM ,
Thompson CM , Wolf JC,
Rogers JM , Haws LC. 2026. Hepatic transcriptomic responses in gravid and non-gravid rats exposed to HFPO-DA: Analyses to inform the role of maternal effects in neonatal toxicity. PLoS One 21(4):e0345643;
doi: 10.1371/journal.pone.0345643 . PMID: 41920860.
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Publication: Manuscripts
2025
Heintz MM , Buerger AN, Haws LC, Cullen JM, East AW, Thompson CM . 2025. Comparison of phenotypic and transcriptomic profiles between HFPO-DA and prototypical PPARα , PPARγ , and cytotoxic agents in wild-type and Pparα -null mouse livers. Toxicol Sci 206(1):183-201; doi: 10.1093/toxsci/kfaf049 . PMID: 40216583.
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Publication: Manuscripts
Heintz MM, Buerger AN, Haws LC, East AW, Cullen JM, Thompson CM . Comparison of phenotypic and transcriptomic profiles between HFPO-DA and prototypical PPARα, PPARγ, and cytotoxic agents in wild-type and PPARα knockout mice. Abstract 3972, Society of Toxicology 64th Annual Meeting, Orlando, FL, March 2025
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Publication: Abstracts and Presentations
2024
Heintz MM , Klaren WD , East AW, Haws LC, McGreal SR, Campbell RR, Thompson CM . 2024. Comparison of transcriptomic profiles between HFPO-DA and prototypical PPARα, PPARγ, and cytotoxic agents in mouse, rat, and pooled human hepatocytes. Toxicol Sci 200(1):165–182; doi: 10.1093/toxsci/kfae044 . PMID: 38574381.
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Publication: Manuscripts
Heintz MM , Klaren WD , East AW, Haws LC, McGreal SR, Campbell RR, Thompson CM . 2024. Comparison of transcriptomic profiles between HFPO-DA and prototypical PPARα, PPARγ, and cytotoxic agents in wild-type and PPARα knockout mouse hepatocytes. Toxicol Sci 200(1):183–198; doi: 10.1093/toxsci/kfae045 . PMID: 38574385.
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Publication: Manuscripts
Tate T, Patlewicz G , Shah I. 2024. A comparison of machine learning approaches for predicting hepatotoxicity potential using chemical structure and targeted transcriptomic data. Comput Toxicol 29(March):100301; doi: 10.1016/j.comtox.2024.100301 . PMID: 38993502.
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Publication: Manuscripts
Heintz M , Klaren W , East A, Haws L, Thompson C . Delayed transcriptomic responses in PPARa knockout mouse hepatocytes compared to wild-type hepatocytes exposed to HFPO-DA or PPARa agonist GW7647: Support for a PPARa-dependent mode of action for HFPO-DA in mouse hepatocytes. Abstract 4100, Society of Toxicology 63rd Annual Meeting, Salt Lake City, UT, March 2024.
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Publication: Abstracts and Presentations
Chang D, Cowden J, Davidson-Fritz S, Dean J, Devito M, Everett L, Harrill A,.., Patlewicz G , et al. 2024. Scientific Studies Supporting Development of Transcriptomic Points of Departure for EPA Transcriptomic Assessment Products (ETAPs). EPA/600/X-23/084. U.S. Environmental Protection Agency: Washington, DC; doi: 10.23645/epacomptox.25365550
Publication: Report
Brennan A, Chang D, Cowden J, Davidson-Fritz S, Dean J, Devito M, Ford J, … , Patlewicz G , et al. 2024. EPA Transcriptomic Assessment Product (ETAP) for Perfluoro-3-Methoxypropanoic Acid. EPA/600/X-24/066. U.S. Environmental Protection Agency: Washington, DC; doi: 10.23645/epacomptox.25352962 .
