Thompson CM , Bichteler A, Rager JE, Suh M , Proctor DM , Haws LC , Harris MA . 2016. Comparison of in vivo genotoxic and carcinogenic potency to augment mode of action analysis: Case study with hexavalent chromium. Mut Res/Genetic Toxicol Environ Mutagen 800-801:28-34.
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Publication: Manuscripts
/ Topics: Cr(VI) MOA Study Manuscripts , Hexavalent Chromium
Bichteler A . 2016. Constrained multiple imputation: A case study in estimation and modeling on data missing below the limit of detection. Presented in the “Melding Dose-Response Relationships” session at the Society of Risk Analysis, December 14, San Diego, CA.
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Publication: Abstracts and Presentations
Wikoff D, Suh M, Harvey S, Proctor D , Beretvas T, Goodman M, Lipworth L. 2016. Systematic review and meta-analysis of occupational exposure to Cr(VI) and stomach cancer. PROSPERO 2016:CRD42016051625 Available from http://www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42016051625
Publication: Protocol Registrations
/ Topics: Chrome VI , Systematic Review
Thompson CM , Rager JE, Suh M , Ring CL, Proctor DM , Haws LC , Fry RC, Harris MA . 2016. Transcriptomic responses in the oral cavity of F344 rats and B6C3F1 mice following exposure to Cr(VI): Implications for risk assessment. Environ Molec Mutagen 57:706-716.
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Publication: Manuscripts
/ Topics: Chrome VI , Cr(VI) MOA Study Manuscripts , Hexavalent Chromium
De Flora S, Camoirano A, Micale RT, La Maestra S, Savarino V, Zentilin P, Marabotto E, Suh M , Proctor DM . 2016. Reduction of hexavalent chromium by fasted and fed human gastric fluid. I. Chemical reduction and mitigation of mutagenicity. Toxicol Appl Pharmaco l 306:113-119.
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Publication: Manuscripts
/ Topics: Chrome VI , Cr(VI) MOA Study Manuscripts
Rager J, Thompson C, Auerbach S, Fry R. 2016. Integrating genomic and epigenomic data into risk assessment applications through dose response modeling: Case study with prenatal arsenic exposure. Environmental Mutagenesis and Genomics Society, September 25, Kansas City, KS.
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Publication: Abstracts and Presentations
Borghoff SJ , Ring C, Banton M, Leavens TL. 2016. Physiologically based pharmacokinetic model for ethyl tertiary-butyl ether and tertiary-butyl alcohol in rats: Contribution of binding to a2u-globulin in male rats and high-exposure nonlinear kinetics to toxicity and cancer outcomes. J Appl Toxicol , DOI 10.1002/jat.3412
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Publication: Manuscripts
/ Topics: Toxicology
Wikoff D , Borghoff S , Rager J , Harvey S , Haws L . 2016. A systematic review of the mechanistic evidence of tetrabromobisphenol TBBPA as a human carcinogen according to the ten key characteristics of carcinogens (TKCC) identified by Smith et al. (2016). PROSPERO 2016:CRD42016046429 Available from: http://www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42016046429
Publication: Protocol Registrations
/ Topics: Systematic Review
Haws L . 2016. Vapor intrusion – Solid ground or quick sand? Invited Speaker. Presented at the 28th Annual Texas Environmental Superconference, August 5, Austin, TX.
Publication: Abstracts and Presentations
Haws L . 2016. Vapor intrusion – Technical issues. Invited Speaker. Presented at the Semi-Annual South Central Regional Meeting of the Auditing Roundtable, August 3, Austin, TX.
Publication: Abstracts and Presentations
Thompson CM , Suh M , Mittal L , Wikoff D , Welsh B, Proctor DM . 2016. Development of linear and threshold no significant risk levels for inhalation exposure to titanium dioxide using systematic review and mode of action considerations. Regul Toxicol Pharmacol 80:60-70.
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Publication: Manuscripts
/ Topics: Systematic Review
Borghoff SJ . 2016. Organization and review of mechanistic data according to “Ten Key Characteristics of Carcinogens” (TKCC) {Smith et al., 2016}. Presented at the 42nd Annual Summer Meeting of the Toxicology Forum, July, Salt Lake City, UT.
Publication: Abstracts and Presentations
Suh M , Thompson CM , Brorby GP , Mittal L , Proctor DM . 2016. Inhalation cancer risk assessment of cobalt metal. Regul Toxicol Pharm 79(2016):74-82.
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Publication: Manuscripts
Kirman CR, Suh M , Hays SM, Gürleyük H, Gerads R, De Flora S, Parker W, Lin S, Haws LC, Harris MA, Proctor DM . 2016. Reduction of hexavalent chromium by fasted and fed human gastric fluid. II. Ex vivo gastric reduction modeling. Toxicol Appl Pharmacol 306:120-133.
View Abstract
Publication: Manuscripts
/ Topics: Chrome VI , Cr(VI) MOA Study Manuscripts
Haws L. 2016. Trichlorethylene exposure and development of fetal cardiac malformations: What do the data tell us about inhalation exposures resulting from vapor intrusion and potential health risks to pregnant women? – Introduction. Presented at the Society of Toxicology’s 55th Annual Meeting, March 13-17, New Orleans, LA.
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Publication: Abstracts and Presentations
Proctor DM . 2016. Cancer risk assessment for ingested hexavalent chromium: Challenges and controversies – Introduction. Presented at the Society of Toxicology’s 55th Annual Meeting, March 13-17, New Orleans, LA [session introduction; no abstract].
Publication: Abstracts and Presentations
Wikoff D , Borghoff SJ , Rager JE, Haws LC . 2016. Human relevance assessment of tetrabromobisphenol-A (TBBPA) induced uterine adenocarcinomas: Mode of action dependent on high dose molecular initiating event (MIE). Presented in the “Flame Retardants” session at the Society of Toxicology’s 55th Annual Meeting, March 13-17, New Orleans, LA.
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Publication: Abstracts and Presentations
Borghoff SJ , Wikoff D , Rager JE , Haws LC . 2016. Tetrabromobisphenol A (TBBPA); Dose- and time-dependent changes in plasma TBBPA and its conjugates over 28 days of administration. Presented at the Society of Toxicology’s 55th Annual Meeting, March 13-17, 2016. New Orleans, LA.
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Publication: Abstracts and Presentations
DeVito MJ, Borghoff SJ , Zorilla LM, Shockley K, Kissling G, Travlos G. 2016. The effects of a high fat (HF) diet on male diversity outbred (DO) mice. Presented at the Society of Toxicology’s 55th Annual Meeting, March 13-17, New Orleans, LA.
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Publication: Abstracts and Presentations
Cullen JM, Ward JM, Thompson CM . 2016. Re-evaluation and classification of duodenal lesions in B6C3F1 mice and F344 rats from four studies of hexavalent chromium in drinking water. Presented at the Society of Toxicology’s 55th Annual Meeting, March 13-17, New Orleans, LA.
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Publication: Abstracts and Presentations
/ Topics: Hexavalent Chromium
Thompson CM , Suh M , Proctor DM , Rager JE , Haws LC , and Harris MA . 2016. Assessment of the in vivo genotoxicity of CrVI in target organs identified in a two-year cancer bioassay. Presented at the Society of Toxicology’s 55th Annual Meeting, March 13-17, New Orleans, LA.
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Publication: Abstracts and Presentations
/ Topics: Hexavalent Chromium
Brorby GP , Suh M , Thompson CM , Mittal L , Proctor DM . 2016. Inhalation cancer risk assessment of cobalt metal. Presented at the Society of Toxicology’s 55th Annual Meeting, March 13-17, New Orleans, LA.
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Publication: Abstracts and Presentations
Cullen JM, Ward JM, Thompson CM . 2016. Reevaluation and classification of duodenal lesions in B6C3F1 mice and F344 rats from 4 studies of hexavalent chromium in drinking water. Toxicologic Pathol 44(2):279-89.
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Publication: Manuscripts
/ Topics: Cr(VI) MOA Study Manuscripts , Hexavalent Chromium
Wikoff DS, Britt JK . 2016. The role of systematic review in the practice of toxicology and risk assessment – An appreciation for the primary tool in evidence-based approaches. Toxicology: Open Access 2(110):1-4.
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Publication: Manuscripts
/ Topics: Systematic Review , Toxicology
Wikoff DS, Rager JE, Haws LC, Borghoff SJ . 2016. A high dose mode of action for tetrabromobisphenol A-induced uterine adenocarcinomas in Wistar Han rats: A critical evaluation of key events in an adverse outcome pathway framework. Regul Toxicol Pharmacol 77:143-159. doi: 10.1016/j.yrtph.2016.01.018
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Publication: Manuscripts
Hanlon P, Brorby GP , Krishan M. 2016. A risk-based strategy for evaluating mitigation options for processed-formed compounds in food: Workshop proceedings. Int J Toxicol 35(3):358–370.
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Publication: Manuscripts
Schmitt D, Levy R, Carroll B. 2016. Toxicological evaluation of ß-caryophyllene oil: Subchronic toxicity in rats. Int J Toxicol 35(5):558–567.
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Publication: Manuscripts
/ Topics: Toxicology
Borghoff SJ , Wikoff D , Harvey S , Haws L . 2016. Dose- and time-dependent changes in tissue levels of tetrabromobisphenol A (TBBPA) and its sulfate and glucuronide conjugates following repeated administration to female Wistar Han Rats. Toxicol Rep 3:190-201. doi:10.1016/j.toxrep.2016.01.007
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