Publication Topic

Heintz MM, Buerger AN, Haws LC, Cullen JM, East AW, Thompson CM. 2025. Comparison of phenotypic and transcriptomic profiles between HFPO-DA and prototypical PPARα, PPARγ, and cytotoxic agents in wild-type and Pparα-null mouse livers. Toxicol Sci 206(1):183-201; doi: 10.1093/toxsci/kfaf049. PMID: 40216583.

Heintz MM, Buerger AN, Haws LC, East AW, Cullen JM, Thompson CM. Comparison of phenotypic and transcriptomic profiles between HFPO-DA and prototypical PPARα, PPARγ, and cytotoxic agents in wild-type and PPARα knockout mice. Abstract 3972, Society of Toxicology 64^th Annual Meeting, Orlando, FL, March 2025

Heintz MM, Klaren WD, East AW, Haws LC, McGreal SR, Campbell RR, Thompson CM. 2024. Comparison of transcriptomic profiles between HFPO-DA and prototypical PPARα, PPARγ, and cytotoxic agents in mouse, rat, and pooled human hepatocytes. Toxicol Sci 200(1):165–182; doi: 10.1093/toxsci/kfae044. PMID: 38574381.

Heintz MM, Klaren WD, East AW, Haws LC, McGreal SR, Campbell RR, Thompson CM. 2024. Comparison of transcriptomic profiles between HFPO-DA and prototypical PPARα, PPARγ, and cytotoxic agents in wild-type and PPARα knockout mouse hepatocytes. Toxicol Sci 200(1):183–198; doi: 10.1093/toxsci/kfae045. PMID: 38574385.

Tate T, Patlewicz G, Shah I. 2024. A comparison of machine learning approaches for predicting hepatotoxicity potential using chemical structure and targeted transcriptomic data. Comput Toxicol 29(March):100301; doi: 10.1016/j.comtox.2024.100301. PMID: 38993502.

Heintz M, Klaren W, East A, Haws L, Thompson C. Delayed transcriptomic responses in PPARa knockout mouse hepatocytes compared to wild-type hepatocytes exposed to HFPO-DA or PPARa agonist GW7647: Support for a PPARa-dependent mode of action for HFPO-DA in mouse hepatocytes. Abstract 4100, Society of Toxicology 63rd Annual Meeting, Salt Lake City, UT, March 2024.

Chang D, Cowden J, Davidson-Fritz S, Dean J, Devito M, Everett L, Harrill A,.., Patlewicz G, et al. 2024. Scientific Studies Supporting Development of Transcriptomic Points of Departure for EPA Transcriptomic Assessment Products (ETAPs). EPA/600/X-23/084. U.S. Environmental Protection Agency: Washington, DC; doi: 10.23645/epacomptox.25365550.

Brennan A, Chang D, Cowden J, Davidson-Fritz S, Dean J, Devito M, Ford J, … , Patlewicz G, et al. 2024. EPA Transcriptomic Assessment Product (ETAP) for Perfluoro-3-Methoxypropanoic Acid. EPA/600/X-24/066. U.S. Environmental Protection Agency: Washington, DC; doi: 10.23645/epacomptox.25352962.

Klaren WD, Heintz MM, East AW, Thompson CM, Haws LC. In vitro transcriptomic analyses informing the mode of action of HFPO-DA (GenX) in the liver. Poster presented at Society of Toxicology Annual Meeting, Nashville, TN, March 2023.

Shah I, Bundy J, Chambers B, Everett L, Haggard D, Harrill J, Judson R, Nyffeler J, Patlewicz G. 2022. Navigating transcriptomic connectivity mapping workflows to link chemicals with bioactivities. Chem Res Toxicol 35(11):1929-1949; doi: 10.1021/acs.chemrestox.2c00245. PMID: 36301716.