Rager JE, Suh M , Chappell G, Thompson CM , Proctor DM . 2019. Review of transcriptomic responses to hexavalent chromium exposure in lung cells supports a role of epigenetic mediators in carcinogenesis. Toxicol Lett 305:40–50.
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Publication: Manuscripts
/ Topics: Chrome VI
Wikoff DS , Rager JE, Chappell GA, Fitch S , Haws L , Borghoff SJ . 2019. A framework for systematic evaluation and quantitative integration of mechanistic data in assessments of potential human carcinogens. Toxicol Sci 167(2):322-335.
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Publication: Manuscripts
Kimzey AL , Piche M-S, Wood M , Weir AB, Lansita J . 2018. 11.19 – Immunophenotyping in drug development. In: Comprehensive Toxicology, 3rd Ed. Vol 11:399–427 .
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Publication: Book Chapters
/ Topics: Toxicology
Tsaioun K, Dirven H, Beck Færden K, Wikoff D , Ram R, Kleinstreuer N, McCormack A, Wright R, Vist GE, Fitch S . 2018. Systematic reviews of the hepatotoxic effects of specified compounds/drugs as observed in humans and experimental animals (rats, mice, dogs and non-human primates). PROSPERO CRD42018112353 .
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Publication: Manuscripts , Protocol Registrations
/ Topics: Toxicology
Borghoff SJ, Fitch S , Rager JE, Huggett D. 2018. A hypothesis-driven weight-of-evidence analysis to evaluate potential endocrine activity of perfluorohexanoic acid. Regul Toxicol Pharmacol 99:168–181.
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Publication: Manuscripts
/ Topics: PFAS , Toxicology
Moffat I, Martinova N, Seidel C, Thompson CM. 2018. Hexavalent chromium in drinking water. Journal AWWA 110:5.
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Publication: Manuscripts
/ Topics: Chrome VI
Wikoff D , Goodrum P, Haws L , Budinsky R. Application of quantitative approaches to assess uncertainties in the development of toxicity values: A case study involving the reference dose (RfD) for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Society of Toxicology Annual Meeting. March 11–15, 2018. San Antonio, TX.
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Publication: Abstracts and Presentations
Urban JD , Harvey S , Haws LC , Wikoff D . Assessment of study quality (risk of bias) in understanding the relationship between congenital heart defects (CHDs) and exposures to trichloroethylene (TCE). Society of Toxicology Annual Meeting. March 11–15, 2018. San Antonio, TX.
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Publication: Abstracts and Presentations
Wikoff D . Moving beyond theory to the use of systematic review to support regulatory decision making for evidence-based risk assessment. Society of Toxicology Annual Meeting. March 11–15, 2018. San Antonio, TX.
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Publication: Abstracts and Presentations
/ Topics: Systematic Review
Borghoff S , Wikoff D , Urban JD , Rager JE . A systematic approach to identify plausible mode-of-actions (MOA) for an increased incidence of lung tumors in mice with chronic exposure to 4-methylimidazole (4-MEI). Society of Toxicology Annual Meeting. March 11–15, 2018. San Antonio, TX.
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Publication: Abstracts and Presentations
/ Topics: Toxicology
Wikoff DS , Miller GW. 2018. Systematic reviews in toxicology (Editorial). Toxicol Sci 163(2):335–337.
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Publication: Manuscripts
/ Topics: Systematic Review , Toxicology
Proctor DM. Hexavalent chromium in drinking water: When is the science sufficient to deviate from defaults? Invited Speaker, Genetic and Environmental Toxicology Association (GETA). Thresholds in Toxicology and Risk Assessment Fall Symposium. Oakland, CA,November 14, 2018.
Publication: Abstracts and Presentations
/ Topics: Hexavalent Chromium
Thompson CM, Wolf JC, Suh M, Proctor DM , Haws LC, Harris MA. Toxicity and recovery in the duodenum of B6C3F1 mice following treatment with intestinal carcinogens; captan, folpet, and hexavalent chromium: Evidence for an adverse outcome pathway. Society of Toxicology Annual Meeting, San Antonio, TX, March 11-15, 2018
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Publication: Abstracts and Presentations
/ Topics: Chrome VI
Thompson CM, Suh M, Proctor DM , Harris MA. Ten factors for considering the mode of action of Cr(VI)-induced intestinal tumors in rodents. Society of Toxicology Annual Meeting, San Antonio, TX, March 11-15, 2018.
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Publication: Abstracts and Presentations
/ Topics: Chrome VI
Proctor, DM . Updating the regulatory risk assessment for hexavalent chromium in California: Implications for regulatory standards. Association of Environmental Health Sciences San Diego, CA, March 20, 2018.
Publication: Abstracts and Presentations
/ Topics: Chrome VI
Thompson CT , Suh M , Chappell G, Borghoff S , Ellis-Hutchings R, Wiench K, Finch L, Proctor DM . 2018. Assessment of the mode of action underlying development of forestomach tumors in rodents following oral exposure to ethyl acrylate and relevance to humans. Regul Toxicol Pharmacol 96:178–189 doi: 10.1016/j.yrtph.2018.05.006.
Publication: Manuscripts
/ Topics: PFAS , Toxicology
Suh M , Proctor DM , Chappell G, Rager JE, Thompson CM , Borghoff S , Finch L, Ellis-Hutchings R, Wiench K. 2018. A review of the genotoxic, mutagenic, and carcinogenic potentials of several lower acrylates. Toxicology 402-403:50-67, doi: 10.1016/j.tox.2018.04.006.
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Publication: Manuscripts
/ Topics: Toxicology
Proctor DM , Suh M , Chappell G, Borghoff SJ , Thompson CM , Wiench K, Finch L, Ellis-Hutchings R. 2018. An adverse outcome pathway (AOP) for forestomach tumors induced by non-genotoxic initiating events. Regul Toxicol Pharmacol , 96:30-40, doi: 10.1016/j.yrtph.2018.04.016.
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Publication: Manuscripts
/ Topics: Toxicology
Sheridan ER, Jackson M, Paleja A, Martini C, Rashid A, Lea I , Fostel J. Improved searching in the Chemical Effects in Biological Systems (CEBS) database leads to greater utility of NTP data. Presented at the 57th Annual Meeting of Society of Toxicology, San Antonio, TX, March 2018. Abstract 2525-P887.
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Publication: Abstracts and Presentations
/ Topics: Toxicology
Lea IA , Borghoff S, Travlos GS. 2018. Electrolytes, blood gases and acid-base balance. In: Kurtz DM, Travlos GS (eds): The Clinical Chemistry of Laboratory Animals (3rd edition). CRC Press, Boca Raton, FL (https://doi.org/10.1201/9781315155807 ).
Publication: Book Chapters
/ Topics: Toxicology
Brorby GP . 2018. The ongoing controversy surrounding the effects of short-term exposure to trichloroethene. Presented at the Association for Environmental Health and Sciences Foundation Annual International Conference, March 19–22, San Diego, CA.
Publication: Abstracts and Presentations
/ Topics: Toxicology
Thompson CM , Kirman CR, Hays SM, Suh M , Harvey SE, Proctor DM , Rager JE , Haws LC , Harris MA . 2018. Integration of mechanistic and pharmacokinetic information to derive oral reference dose and margin-of-exposure values for hexavalent chromium. J Appl Toxicol 38:351–365. doi: 10.1002/jat.3545.
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Publication: Manuscripts
/ Topics: Hexavalent Chromium
Verougstraete V, Henderson R , Mackie C, Newson T, Oller A. 2018. Human health (toxicity) assessment of complex inorganic materials. In: Verougstraete V (ed), Risk Management of Complex Inorganic Materials. Elsevier Inc. ISBN 978-0-12-811063-8.
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Publication: Book Chapters
/ Topics: Metals
Wikoff D, Urban JD, Harvey S, Haws LC . 2018. Role of risk of bias in systematic review for chemical risk assessment: A case study in understanding the relationship between congenital heart defects and exposures to trichloroethylene. Int J Toxicol , DOI: 0.1177/1091581818754330.
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Publication: Manuscripts
/ Topics: Systematic Review , Toxicology
Wikoff DS , Rager JE, Harvey S , Haws L , Chappell G, Borghoff S . Development and refinement of a framework for quantitative consideration of study quality and relevance in the evaluation of mechanistic data based on Key Characteristics of Carcinogens. Society of Risk Analysis Annual Meeting. December 10-14, 2017. Arlington, VA.
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Publication: Abstracts and Presentations
Wikoff DS , Welsh BT, Henderson R , Brorby G , Britt J , Myers E, Goldberger J, Lieberman HR, O’Brien C, Doepker C . Application of systematic reviews in the evaluation of caffeine safety: Potential adverse effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children. Society of Risk Analysis Annual Meeting. December 10-14, 2017. Arlington, VA.
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