2025
Lea IA , Holt J, Bunnage E, Long M, Chew R, Bell S, Edwards S, Sayre R, Vliet SM, Lynn SG, Kristan MJ. Integrated computational approaches in systematic evidence mapping: Bridging human expertise and machine learning for advanced toxicological assessments. Abstract 3409, Society of Toxicology 64th Annual Meeting, Orlando, FL, March 2025.
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Publication: Abstracts and Presentations
Wikoff DS, Vincent MJ, Heintz MM , Pastula ST, Reichert H, Klaren WD , Haws LC. 2025. Application of a quantitative uncertainty assessment to develop ranges of plausible toxicity values when using observational data in risk assessment: A case study examining associations between PFOA and PFOS exposures and vaccine response. Toxicol Sci 204(1):96-115; doi: 10.1093/toxsci/kfae152 . PMID: 39792025.
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Publication: Manuscripts
2024
Lea IA , Borghoff SJ, Chew R, Bell S, Edwards S, Vasko J, et al. Leveraging computational tools for enhanced human-in-the-loop systematic literature reviews. American Society of Cellular and Computational Toxicology Annual Meeting, Research Triangle Park, NC, October 2024.
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Publication: Abstracts and Presentations
Holt JR, Chew RF, Bunnage E, Lea I, Borghoff SJ, Sayer R, et al. Categorizing articles for environmental health systematic evidence mapping: A zero-shot machine learning approach using large language models. American Society of Cellular and Computational Toxicology Annual Meeting, Research Triangle Park, NC, October 2024.
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Publication: Abstracts and Presentations
Wikoff D , Fitch S . 2024. Evidence‐based methods in toxicology: Systematic review and systematic evidence mapping. Chapter 32 in: Paustenbach DJ (ed), Human and Ecological Risk Assessment: Theory and Practice, Third Edition, pp. 1133–1148. Wiley , ISBN: 978-1-119-74296-8.
Publication: Book Chapters
Yoshino T, Hooda N, Younan D, Muro K, Shitara K, Heinemann V,… Suh M, Reichert H, Mezzi K, Fryzek J, et al. 2024. A meta-analysis of efficacy and safety data from head-to-head first-line trials of epidermal growth factor receptor inhibitors versus bevacizumab in adult patients with RAS wild-type metastatic colorectal cancer by sidedness. Eur J Cancer 202:113975; doi: 10.1016/j.ejca.2024.113975 . PMID: 38442645.
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Publication: Manuscripts
Lynn SG, Lea IA , Urban J , Borghoff SJ , Wikoff D , Fitch S , Perry C , C hoksi N , Britt J , Heintz M , Klaren W , et al. Development and application of systematic approach to inventory and interrogate thyroid hormone network information. Abstract 4357, Society of Toxicology 63rd Annual Meeting, Salt Lake City, UT, March 2024.
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Publication: Abstracts and Presentations
Fitch S, Blanchette A, Haws LC, Franke K, Ring C, DeVito M, Wheeler M,… Wikoff DS . 2024. Systematic update to the mammalian relative potency estimate database and development of best estimate toxic equivalency factors for dioxin-like compounds. Regul Toxicol Pharmacol 147(Feb):105571; doi: 10.1016/j.yrtph.2024.105571 . PMID: 38244664.
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Publication: Manuscripts
2023
Wikoff D , Fitch S . 2024. Systematic reviews and evidence-based methods in toxicology. In: Wexler P (ed), Encyclopedia of Toxicology. Elsevier, pp. 875–882.