2026
Kennedy SB, Heintz MM , Brown L, Fender CL, Hecker M, Hughes SA, Naile J, DeLeo P. Defining the domain of applicability: A case study to increase confidence in toxicogenomic tools for ecological risk assessment. Poster 1.03.P-Tu032 , SETAC Europe 36th Annual Meeting, Maastricht, The Netherlands, May 19, 2026.
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Topics: ecotoxicology , NAMs , risk assessment , transcriptomics
Fitch S , Lozy F, Mitchell C, Patlewicz G , Wood A. Use of new approach methodologies in the safety assessment of dietary supplements—Parts one and two . Webinar series, Council for Responsible Nutrition (CRN), Washington, DC, May 2026.
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Topics: food additives , food safety , Food science , NAMs , safety assessment
Doepker C, Franzen A , Brorby G *, Wikoff D , Thompson C . From alerts to evidence: Advancing the use of in vivo genotoxicity dose-response data for complex mixtures. Poster/Abstract PA3, International Conference on the Science of Botanicals (ICSB), Oxford, MS, April 2026. (*poster only )
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Topics: dose-response , genotoxicity
Wikoff D , Brown L. Development of an integrated human and environmental health safety assessment framework: Initial findings and progress from a consortium effort. Abstract 1050, Society of Toxicology 65th Annual Meeting, San Diego, CA, March 2026.
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Topics: collaboration , ecotoxicology , Environmental Science
Wikoff D , Fitch S , Eichenbaum G, Ejaz S, Klaren W , Southall M. Need for fit-for-purpose approaches that integrate dose, mechanism, and context of use with key characteristics when evaluating the carcinogenic potential of widely used therapeutics: A case study of acetaminophen. Abstract 4005, Society of Toxicology 65th Annual Meeting, San Diego, CA, March 2026.
Topics: carcinogens , chemical safety assessment , dose-response
Vincent M, Wheeler M, Schaefer H, Rhoden J, Fitch S , Wikoff D . Quantitative bias assessment to facilitate assessment of (un)certainty in observational data evaluating acetaminophen use and liver cancer. Abstract 4279, Society of Toxicology 65th Annual Meeting, San Diego, CA, March 2026.
Topics: Cancer , chemical safety assessment , risk assessment , safety assessment
Shobair M, Allen D, Ballone I, Brull M, Burbank M, Choksi N, Fitch S , Irizar A, et al. A machine-learning approach for the development of a knowledgebase to identify systemic toxicity mechanistic targets and evaluate biological space coverage. Abstract 5161, Society of Toxicology 65th Annual Meeting, San Diego, CA, March 2026.
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Topics: computational toxicology , NAMs , risk assessment
Proctor DM, Verwiel AH, Covington TR, Thompson CM . Acute (24-hour) nickel inhalation reference concentration for use in air toxics risk assessment. Abstract 3997, Society of Toxicology 65th Annual Meeting, San Diego, CA, March 2026.
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Topics: inhalation toxicology , nickel
Patlewicz G , Mihalchik A , Thompson CM , East A, Borghoff S . Investigating the feasibility of deriving a new environmentally relevant Thresholds of Toxicological Concern (TTCs) from estimated human equivalent benchmark dose (eBMDHED ) values. Abstract 4013, Society of Toxicology 65th Annual Meeting, San Diego, CA, March 2026.
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Topics: genotoxicity , risk analysis , risk assessment
Lea I , Rivera B, Rogers S, Borghoff SJ . Assessment of the carcinogenic potential of automotive gasoline in humans based on mechanistic evidence. Abstract 5206, Society of Toxicology 65th Annual Meeting, San Diego, CA, March 2026.
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