Publication Topic

Nagyal M, Kopanska K, Rovida C, Antignac E, Barton-Maclaren T, Congreave I, Escher SE,…, Patlewicz G, et al. From thresholds to odds: AI-enhanced applications of the threshold of toxicological concern (TTC) in modern risk assessment. Oral Session 3, Poster OR-12, American Society for Cellular and Computational Toxicology (ASCCT) 15^th Annual Meeting, Durham, NC, October 28, 2026.

Mihalchik AL. TTC in context: Comparing the pharmaceutical TTC with other regulatory sectors. Oral Session 3, Poster OR-09, American Society for Cellular and Computational Toxicology (ASCCT) 15^th Annual Meeting, Durham, NC, October 28, 2026.

Schaefer HR, Frankenfeld CL, Wikoff D. 2026. Low- and no-calorie sweeteners lack shared target organs or modes of action required for cumulative risk assessment. Food Chem Toxicol 218(Dec):116424; doi: 10.1016/j.fct.2026.116424. PMID: 42829191. 

Wikoff D, Wages PA. Where science meets reality: The role of real-world evidence (RWE) in modern personal care safety assessment. 2026 Personal Care Products Council (PCPC) Science Symposium & Expo, Arlington, VA, September 17, 2026.

Bearth A, Kopainsky B, Jones LB, Vist GE, Husoy T, Svendsen C, Whaley P,…, Wikoff D, et al. 2026. Modelling the regulatory toxicology system to promote the effective use of new approach methodologies: A system thinking approach. NAM J 2(Jul 24):100120; doi: 10.1016/j.namjnl.2026.100120. PMID: 42569723

Kirman CR, Lipscomb JC, Rogers J, Schoeny RS, Seed JG, Sonawane BR, Hays SM. 2026. Evaluation of the modes of action for key noncancer effects of 1,3-Butadiene: Input from an independent expert panel to support derivation of data-derived extrapolation factors. Crit Rev Toxicol 56(4):252-278; doi: 10.1080/10408444.2026.2661191. PMID: 42261678.

Buerger AN, Thompson CM, Heintz MM, Maberti S, Palermo CM, Haws LC. 2026. Application of quantitative and qualitative uncertainty assessment risk management decision-making: A case study with diisononyl phthalate. Food Chem Toxicol 214(Aug):116110; doi: 10.1016/j.fct.2026116110. PMID: 42035978.

Kennedy SB, Heintz MM, Brown L, Fender CL, Hecker M, Hughes SA, Naile J, DeLeo P. Defining the domain of applicability: A case study to increase confidence in toxicogenomic tools for ecological risk assessment. Poster 1.03.P-Tu032, SETAC Europe 36^th Annual Meeting, Maastricht, The Netherlands, May 19, 2026.

Thompson CM, Heintz MM, Rogers SI, Vincent MJ, Haws LC. 2026. Integration of mechanistic and repeat dose toxicity data in the derivation of an oral reference dose for HFPO-DA. Toxicol Sci 209(5):kfag045; doi: 10.1093/toxsci/kfag045. PMID: 41968070.

Doepker C, Franzen A, Brorby G, Brown L, Choksi N, East A, Wikoff D. 2026. Smoke flavoring—A case study demonstrating the value of using benefit-risk analysis for foods (BRAFO) to provide transparency for risk management decisions. Regul Toxicol Pharmacol 167(May):106033; doi: 10.1016/j.yrtph.2026.106033. PMID: 41577161.