2024
Thompson CM , Heintz MM , Rogers SI, Fitch SE , Rivera BN, Klaren WD , Vincent MJ, Wikoff DS , Haws LC. Evidence identification and appraisal supporting development of an updated toxicity value for HFPO-DA. Abstract 3654, Society of Toxicology 63rd Annual Meeting, Salt Lake City, UT, March 2024.
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Publication: Abstracts and Presentations
/ Topics: evidence-based reviews , PFAS , Toxicology
Heintz M , Klaren W , East A, Haws L, Thompson C . Delayed transcriptomic responses in PPARa knockout mouse hepatocytes compared to wild-type hepatocytes exposed to HFPO-DA or PPARa agonist GW7647: Support for a PPARa-dependent mode of action for HFPO-DA in mouse hepatocytes. Abstract 4100, Society of Toxicology 63rd Annual Meeting, Salt Lake City, UT, March 2024.
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Publication: Abstracts and Presentations
/ Topics: transcriptomics
Franke K, Vincent M, Rogers S , Rivera B, Wikoff D . Assessment of non-occupational exposures to cleaning products and the incidence of asthma and respiratory disease. Abstract 3393, Society of Toxicology 63rd Annual Meeting, Salt Lake City, UT, March 2024.
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Publication: Abstracts and Presentations
/ Topics: chemical safety assessment , Exposure Assessment
Bever RJ, Edwards SW, Antonijevic T, Nelms MD, Ring C, Harris D, Lynn SG, Williams D, Chappell G, Boyles R, Borghoff S , Markey KJ. 2024. Optimizing androgen receptor prioritization using high-throughput assay-based activity models. Front Toxicol 6(March 11):1347364; doi: 10.3389/ftox.2024.1347364 . PMID: 38529103.
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Publication: Manuscripts
/ Topics: modeling
Chang D, Cowden J, Davidson-Fritz S, Dean J, Devito M, Everett L, Harrill A,.., Patlewicz G , et al. 2024. Scientific Studies Supporting Development of Transcriptomic Points of Departure for EPA Transcriptomic Assessment Products (ETAPs). EPA/600/X-23/084. U.S. Environmental Protection Agency: Washington, DC; doi: 10.23645/epacomptox.25365550 .
Publication: Report
/ Topics: risk assessment , transcriptomics
Brennan A, Chang D, Cowden J, Davidson-Fritz S, Dean J, Devito M, Ford J, … , Patlewicz G , et al. 2024. EPA Transcriptomic Assessment Product (ETAP) for Perfluoro-3-Methoxypropanoic Acid. EPA/600/X-24/066. U.S. Environmental Protection Agency: Washington, DC; doi: 10.23645/epacomptox.25352962 .
Publication: Report
/ Topics: risk assessment , transcriptomics
Patlewicz G . Comparing expert-driven read-across assessments using the generalized read-across framework. Abstract 1110, Society of Toxicology 63rd Annual Meeting, Salt Lake City, UT, March 2024.
Publication: Abstracts and Presentations
/ Topics: read-across
Thompson CM , Heintz MM , Cullen JM, Haws LC. 2024. Letter to the Editor of Environmental Pollution: In regard to Wan et al. (2024), “GenX caused liver injury and potential hepatocellular carcinoma of mice via drinking water even at environmental concentration.” Environ Pollut 355(Aug 15):124171; doi: 10.1016/j.envpol.2024.1241741 . PMID: 38776993.
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Publication: Manuscripts
/ Topics: Cancer , water
Shirke AV, Radke EG, Lin C, Blain R, Vetter N, Lemeris C, Hartman P,.., Patlewicz G , et al. 2024. Expanded systematic evidence map for hundreds of per- and polyfluoroalkyl substances (PFAS) and comprehensive PFAS human health dashboard. Environ Health Perspect 132(2):026001; doi: 10.1289/EHP134 . PMID: 38319881.
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Publication: Manuscripts
/ Topics: PFAS
Racz L, Gauthier A, Bare J, Heintz M , Feifarek D, Kennedy S, Panko J. 2024. Assessment of perfluorocarboxylic acids in fluorinated high-density polyethylene containers and estimation of potential non-cancer risks associated with anticipated use scenarios. Regul Toxicol Pharmacol 147(Feb):105560; doi: 10.1016/j.yrtph.2024.105560 . PMID: 38182014.
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