Publications

Hooda N, Suh M, Bylsma LC, Kelsh M. A systematic literature review of the association between dose reduction of cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors and survival in patients with HR-positive breast cancer (BC). Poster 1882eP, European Society for Medical Oncology (ESMO) Congress 2026, Madrid, Spain, October 23-27, 2026.

Kopanska K, Rovida C, Antignac E, Barton-Maclaren T, Congreave I, Escher SE, Herzler M,…, Patlewicz G, et al. From thresholds to odds: AI-enhanced applications of the threshold of toxicological concern (TTC) in modern risk assessment. Oral Session 3, Poster OR-12, American Society for Cellular and Computational Toxicology (ASCCT) 15^th Annual Meeting, Durham, NC, October 28, 2026.

Mihalchik AL. TTC in context: Comparing the pharmaceutical TTC with other regulatory sectors. Poster OR-09, Oral Session 3, American Society for Cellular and Computational Toxicology (ASCCT) 15^th Annual Meeting, Durham, NC, October 28, 2026.

Covington T, Borghoff SJ, Sims JL, Kamel A, Markey K, Wetmore BA, Lynn SG. Use of an in silico mass balance model to predict chemical suitability for screening chemicals in a high-throughput assay platform for potential endocrine activity. Poster 3, Poster Session II, American Society for Cellular and Computational Toxicology (ASCCT) 15^th Annual Meeting, Durham, NC, October 28, 2026

Patlewicz G, Mihalchik AL. Refinement of the threshold of toxicological concern (TTC): A computational framework for cross-scheme comparison of TTC values. Poster 24, Poster Session 1, American Society for Cellular and Computational Toxicology (ASCCT) 15^th Annual Meeting, Durham, NC, October 27, 2026.

Schaefer HR, Frankenfeld CL, Wikoff D. 2026. Low- and no-calorie sweeteners lack shared target organs or modes of action required for cumulative risk assessment. Food Chem Toxicol 218(Dec):116424; doi: 10.1016/j.fct.2026.116424. PMID: 42829191. 

Mihalchik AL, Roberts A, LaCombe J, Lloyd M, Doepker C, Eapen A. 2026. Evaluation of the safety and potential genotoxicity of a high-purity mogroside ingredient containing siamenoside I produced from a modified strain of Yarrowia lipolytica. Toxicol Rep 17(Dec):102297; doi: 10.1016/j.toxrep.2026.102297. PMID: 42388455.

East A, Klaren W, Wikoff D, Patlewicz G. Identifying potential co-exposures with food additives using data mining and machine learning approaches across EPA’s Consumer Product Database (CPDat). Abstract M-36, Poster Session, International Society of Exposure Science (ISES) 2026 Annual Meeting, Vancouver, BC, Canada, October 5, 2026.

Patlewicz GY, Mihalchik AL. 2026. Revisiting the Threshold of Toxicological Concern: A computational framework for structural classification, cross-scheme comparison and opportunities for refinement. Comput Toxicol 39(Sept):100443; doi: 10.1016/j.comtox.2026.100443.

Wikoff D, Wages PA. Where science meets reality: The role of real-world evidence (RWE) in modern personal care safety assessment. 2026 Personal Care Products Council (PCPC) Science Symposium & Expo, Arlington, VA, September 17, 2026.