Publications

Wikoff D, Brown L. Development of an integrated human and environmental health safety assessment framework: Initial findings and progress from a consortium effort. Abstract 1050, Society of Toxicology 65^th Annual Meeting, San Diego, CA, March 2026.

Wikoff D, Fitch S, Eichenbaum G, Ejaz S, Klaren W, Southall M. Need for fit-for-purpose approaches that integrate dose, mechanism, and context of use with key characteristics when evaluating the carcinogenic potential of widely used therapeutics: A case study of acetaminophen. Abstract 4005, Society of Toxicology 65^th Annual Meeting, San Diego, CA, March 2026.

Vincent M, Wheeler M, Schaefer H, Rhoden J, Fitch S, Wikoff D. Quantitative bias assessment to facilitate assessment of (un)certainty in observational data evaluating acetaminophen use and liver cancer. Abstract 4279, Society of Toxicology 65^th Annual Meeting, San Diego, CA, March 2026.

Shobair M, Allen D, Ballone I, Brull M, Burbank M, Choksi N, Fitch S, Irizar A, et al. A machine-learning approach for the development of a knowledgebase to identify systemic toxicity mechanistic targets and evaluate biological space coverage. Abstract 5161, Society of Toxicology 65^th Annual Meeting, San Diego, CA, March 2026.

Proctor DM, Verwiel AH, Covington TR, Thompson CM. Acute (24-hour) nickel inhalation reference concentration for use in air toxics risk assessment. Abstract 3997, Society of Toxicology 65^th Annual Meeting, San Diego, CA, March 2026.

Patlewicz G, Mihalchik A, Thompson CM, East A, Borghoff S. Investigating the feasibility of deriving a new environmentally relevant Thresholds of Toxicological Concern (TTCs) from estimated human equivalent benchmark dose (eBMD_HED) values. Abstract 4013, Society of Toxicology 65^th Annual Meeting, San Diego, CA, March 2026.

Lea I, Rivera B, Rogers S, Borghoff SJ. Assessment of the carcinogenic potential of automotive gasoline in humans based on mechanistic evidence. Abstract 5206, Society of Toxicology 65^th Annual Meeting, San Diego, CA, March 2026.

Klaren WD, Rivera BN, Sheppard AM, Franke K, Wikoff DS. Approach for systematically assessing study reliability and relevance in evaluations of monosodium glutamate safety. Abstract 3653, Society of Toxicology 65^th Annual Meeting, San Diego, CA, March 2026.

Klaren WD, East A, Wheeler M, Vincent M, Wikoff DS, Covington T. Probabilistic estimation of daily total nitrosamine exposures generated from drinking water and dietary nitrate and nitrate sources. Abstract 3982, Society of Toxicology 65^th Annual Meeting, San Diego, CA, March 2026.