Publications

Wikoff D, Fitch S, Borghoff S. Case-study applications using evidence-based approaches to assess endocrine activity for risk assessment. Invited speaker (Wikoff):  61^st Annual Meeting (virtual) of the Society for Birth Defects Research & Prevention, June 2021.

Wikoff D. The [acceptable daily intake] for low- and no-calorie sweeteners: Origin, interpretation, and application. Invited speaker: Continuing education webinar, Institute for the Advancement of Food and Nutrition Sciences, July 2021.

Fitch SE, Payne LE, van de Ligt JLG, Doepker C, Handu D, Cohen SM, Anyangwe N, Wikoff D. 2021. Use of acceptable daily intake (ADI) as a health-based benchmark in nutrition research studies that consider the safety of low-calorie sweeteners (LCS): A systematic map. BMC Public Health 21(1):956, doi: 10.1186/s12889-021-10934-2.

Borghoff SJ, Fitch SE, Black MVB, McMullen PD, Andersen ME, Chappell GA. 2021. A systematic approach to evaluate plausible modes of [action] for mouse lung tumors in mice exposed to 4-methylimidozole. Regul Toxicol Pharmacol 124:104977; DOI: 10.1016/j.yrtph.2021.104977.

Whaley P, Blaauboer BJ, Brozek J, Cohen Hubal EA, Hair K, Kacew S, Knudsen TB, Kwiatkowski CF, Mellor DT, Olshan AF, Page MJ, Rooney AA, Radke E, Shamseer L, Tsaioun K, Tugwell P, Wikoff D, Woodruff TJ. 2021. Improving the quality of toxicology and environmental health systematic reviews: What journal editors can do. ALTEX [Internet].

Proctor DM, Bhat V, Suh M, Reichert H, Jiang X, Thompson CM. 2021. Inhalation cancer risk assessment for environmental exposure to hexavalent chromium: Comparison of margin-of-exposure and linear extrapolation approaches. Regul Toxicol Pharmacol 124:104969, doi.org/10.1016/j.yrtph.2021.104969.

de Vries RBM, Angrish M, Browne P, Brozek J, Rooney AA, Wikoff DS, Whaley P, Edwards SW, Morgan RL, Druwe IL, Hoffmann S, Hartung T, Thayer K, Avey MT, Beverly BEJ, Falavigna M, Gibbons C, Goyak K, Kraft A, Nampo F, Qaseem A, Sears M, Singh JA, Willett C, Yost EY, Schünemann H, Tsaioun K. 2021. Applying evidence-based methods to the development and use of adverse outcome pathways. ALTEX — Alternatives to Animal Experimentation, 38(2):336–347, doi: 10.14573/altex.2101211.

Saili KS, Antonijevic T, Zurlinden TJ, Shah I, Deisenroth C, Knudsen TB. 2020. Molecular characterization of a toxicological tipping point during human stem cell differentiation. Reprod Toxicol 91:1–13 (selected as journal’s best paper of 2020).

Dirven H, Vist GE, Bandhakavi S, Mehta J, Fitch SE, Pound P, Ram R, Kincaid B, Leenaars CHC, Chen M, Wright RA, Tsaioun K. 2021. Performance of preclinical models in predicting drug-induced liver injury in humans: A systematic review. Nature, Scientific Reports; open access.

Chappell GA, Heintz MM, Borghoff SJ, Doepker CL, Wikoff DS. 2021. Lack of potential carcinogenicity for steviol glycosides — Systematic evaluation and integration of mechanistic data into the totality of evidence. Food Chem Toxicol 150:112045.

Felter SP, Zhang X, Thompson C. 2021. Butylated hydroxyanisole: Carcinogenic food additive to be avoided or harmless antioxidant important to protect food supply? Regul Toxicol Pharmacol 121:104887.

Thompson CM, Gentry R, Fitch S, Lu K, Clewell HJ. 2020. An updated mode of action and human relevance framework evaluation for formaldehyde-related nasal tumors. Crit Rev Toxicol 50(10):919–952, DOI: 10.1080/10408444.2020.1854679.

Gentry R, Thompson CM, Franzen A, Salley J, Albertini R, Lu K, Greene T. 2020. Using mechanistic information to support evidence integration and synthesis: A case study with inhaled formaldehyde and leukemia. Crit Rev Toxicol 50(10):885–918, DOI: 10.1080/10408444.2020.1854678.

Wikoff DS, Urban JD, Ring C, Britt J, Fitch S, Haws LC. 2021. Development of a range of plausible non-cancer toxicity values for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) based on effects on sperm count: Application of systematic review methods and quantitative integration of dose response using meta-regression. Toxicol Sci 179(2):162-182, https://doi.org/10.1093/toxsci/kfaa171.

Chappell GA, Heintz MM, Haws LC. 2021. Transcriptomic analyses of livers from mice exposed to 1,4-dioxane for up to 90 days to assess potential mode(s) of action underlying liver tumor development. Curr Res Toxicol 2:30–41.

Chappell GA, Wikoff DS, Thompson CM. 2021. Assessment of mechanistic data for hexavalent chromium-induced rodent intestinal cancer using the key characteristics of carcinogens. Toxicol Sci (ms. online ahead of print).

Eichenbaum G, Yang K, Gebremichael Y, Howell BA, Murray FJ, Jacobson-Kram D, Jaeschke H, Kuffner E, Gelotte CK, Lai JCK, Wikoff D, Atillasoy E. 2020. Application of the DILIsym® Quantitative Systems Toxicology drug-induced liver injury model to evaluate the carcinogenic hazard potential of acetaminophen. Regul Toxicol Pharmacol 118:104788.

Whaley P, Aiassa E, Beausoleil C, Beronius A, Bilotta, G, Boobis A, de Vries R, Hanberg A, Hoffman S, Hunt N, Kwiatkowski CF, Lam J, Lipworth S, Martin O, Randall, N, Rhomberg L, Rooney AA, Holger J, Schünemann HJ, Wikoff D, Wolffe T, Halsall C. 2020. Recommendations for the conduct of systematic reviews in toxicology and environmental health research (COSTER). Environ Int 143:105926.

Chappell GA, Wikoff DS, Doepker CL, Borghoff SJ. 2020. Lack of potential carcinogenicity for acesulfame potassium — Systematic evaluation and integration of mechanistic data into the totality of the evidence. Food Chem Toxicol 141:111375 [open access].

Chappell GA, Britt JK, Borghoff, SJ. 2020. Systematic assessment of mechanistic data for FDA-certified food colors and neurodevelopmental processes. Food Chem Toxicol 140:111310 [open access].

Haws L (session co-chair). Introduction to “Use of New Approach Methods in Risk Characterization of PFAS: Challenges and Opportunities.” 44^th Annual Winter Meeting, the Toxicology Forum, Tysons, VA, Jan 2020 (see: https://dialogue.toxforum.org/d/do/894).

Ring C. Application of high-throughput exposure modeling in risk-based prioritization for PFAS. Presentation at 44^th Annual Winter Meeting, the Toxicology Forum, Tysons, VA, Jan 2020 (see: https://dialogue.toxforum.org/d/do/900).

Antonijevic T, Shah I. Predicting subchronic and chronic animal toxicity from in vitro high content imaging data using PBTK and machine learning. Poster for Society of Toxicology, Virtual Annual Meeting, 2020.

Henderson RG, Franzen A, Franke K, Payne L, Schmitt D, Wikoff D. Creating a literature database for cannabidiol (CBD): Systematic evidence mapping. Poster for Society of Toxicology, Virtual Annual Meeting, 2020.

Ring C, Fitch S, Haws L, Harris M, Wikoff D. Quantitative integration of dose-response data for relative potency estimates of dioxin-like chemicals. Poster for Society of Toxicology, Virtual Annual Meeting, 2020.

Suh M, Verwiel A, Proctor D. Oral and inhalation bioaccessibility of cobalt and nickel in metal alloys: A critical consideration for site-specific human health risk assessments and read across. Poster for Society of Toxicology, Virtual Annual Meeting, 2020.

Thompson CM, Ring C, Pham L, Chappell GA, Haws LC. Assessment of the relevance of toxicological findings in the development of an oral reference dose for GenX. Poster for Society of Toxicology, Virtual Annual Meeting, 2020.

Wikoff D, Franzen A, Chappell G, Harris M, Thompson C. Systematic characterization of hexavalent chromium and potential female reproductive outcomes: Application of US EPA critical appraisal tools and stepwise inclusion of mechanistic data. Poster for Society of Toxicology, Virtual Annual Meeting, 2020.

Pham LL, Borghoff SJ, Thompson CM. 2020. Comparison of threshold of toxicological concern (TTC) values to oral reference dose (RfD) values. Regul Toxicol Pharmacol 113:104651 [open access].

Bell S, Mansouri K, Phillips J, Chang X, Abedini J, Karmaus AL, Lea I, Rai R, Allen DG, Casey W, Kleinstreuer NC. NCEATM computational tools and resources supporting alternative test method development and evaluation. Presented at the 59th Annual Meeting of Society of Toxicology, Anaheim CA, March 2020. Abstract #2976-P607.

Lea IA, Jackson MA, Li X, Bailey S, Peddada SD, Dunnick JK. 2007. Genetic pathways and mutation profiles of human cancers: Site- and exposure-specific patterns. Carcinogenesis 28:1851–1858.

Wikoff DS, Bennett DC, Brorby GP, Franke KS. 2020. Evaluation of potential human health risk associated with consumption of edible products from livestock fed ration supplemented with Red Lake Diatomaceous Earth. Food Addit Contam Part A; DOI: 10.1080/19440049.2020.1727963.

Chappell GA, Borghoff SJ, Pham L, Doepker CL, Wikoff DS. 2019. Lack of potential carcinogenicity for sucralose — Systematic evaluation and integration of mechanistic data into the totality of the evidence. Food Chem Toxicol 135:110898.

Yoon M, Ring C, Van Landingham CB, Suh M, Song G, Antonijevic T, Gentry PR, Taylor MD, Keen AM, Andersen ME, Clewell JH. 2019. Assessing children’s exposure to manganese in drinking water using a PBPK model. Toxicol Appl Pharmacol 380:114695

Fitch S, Goyak K, Green Maia, Grimm F, Wikoff D. 2019. Estrogen-mediated outcomes for alkylphenols via an adverse outcome pathway (AOP) construct. Open Science Framework, August.

Wikoff D, Haws L Ring C, Budinsky R. 2019. Application of qualitative and quantitative uncertainty assessment tools in developing ranges of plausible toxicity values for 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin. J Appl Toxicol, doi: 10.1002/jat.3814, open access.

Rager JE, Suh M, Chappell G, Thompson CM, Proctor DM. 2019. Review of transcriptomic responses to hexavalent chromium exposure in lung cells supports a role of epigenetic mediators in carcinogenesis. Toxicol Lett 305:40–50.

Sheridan E, Moose J, Liu Y, Martini C, Lea I, Fostel J. NTP high-level summary data collections in the Chemical Effects in Biological Systems (CEBS) database. Presented at the 15th International Congress of Toxicology, Honolulu, HI, July 2019. Poster PS01-0606.

Bhawana B, Lea I, Liu Y, Martini C, Fostel J. Access to National Toxicology Program histopathology lesion collection in Chemical Effects in Biological Systems (CEBS) database. Presented at the 38th Annual Symposium of Society for Toxicologic Pathology, Raleigh, NC, June 2019. Poster P040.

Lea I, Liu Y, Sheridan E, Motti D, Martini C, Fostel J, Auerbach S. Hallmark gene set annotation for NTP toxicogenomic studies. Presented at the 58th Annual Meeting of Society of Toxicology, Baltimore, MD, March 2019. Abstract #1743-P119.

Martini C, Liu Y, Motti D, Johnson J, McCormick K, Lea I, Fostel F. Integrating assay datasets into Chemical Effects in Biological Systems (CEBS). Presented at the 58th Annual Meeting of Society of Toxicology, Baltimore, MD, March 2019. Abstract #1749-P125.

Suh M, Wikoff D, Lipworth L, Goodman M, Fitch S, Mittal L, Ring C, Proctor D. 2019. Hexavalent chromium and stomach cancer: A systematic review and meta-analysis. Crit Rev Toxicol [ePub ahead of print]: doi: 10.1080/10408444.2019.1578730.

Wikoff DS, Rager JE, Chappell GA, Fitch S, Haws L, Borghoff SJ. 2019. A framework for systematic evaluation and quantitative integration of mechanistic data in assessments of potential human carcinogens. Toxicol Sci 167(2):322-335.

Kimzey AL, Piche M-S, Wood M, Weir AB, Lansita J. 2018. 11.19 – Immunophenotyping in drug development. In: Comprehensive Toxicology, 3^rd Ed. Vol 11:399–427.

Tsaioun K, Dirven H, Beck Færden K, Wikoff D, Ram R, Kleinstreuer N, McCormack A, Wright R, Vist GE, Fitch S. 2018. Systematic reviews of the hepatotoxic effects of specified compounds/drugs as observed in humans and experimental animals (rats, mice, dogs and non-human primates). PROSPERO CRD42018112353.

Borghoff SJ, Fitch S, Rager JE, Huggett D. 2018. A hypothesis-driven weight-of-evidence analysis to evaluate potential endocrine activity of perfluorohexanoic acid. Regul Toxicol Pharmacol 99:168–181.

Moffat I, Martinova N, Seidel C, Thompson CM. 2018. Hexavalent chromium in drinking water. Journal AWWA 110:5.

Wikoff D, Goodrum P, Haws L, Budinsky R. Application of quantitative approaches to assess uncertainties in the development of toxicity values: A case study involving the reference dose (RfD) for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Society of Toxicology Annual Meeting. March 11–15, 2018. San Antonio, TX.

Urban JD, Harvey S, Haws LC, Wikoff D. Assessment of study quality (risk of bias) in understanding the relationship between congenital heart defects (CHDs) and exposures to trichloroethylene (TCE). Society of Toxicology Annual Meeting. March 11–15, 2018. San Antonio, TX.

Wikoff D. Moving beyond theory to the use of systematic review to support regulatory decision making for evidence-based risk assessment. Society of Toxicology Annual Meeting. March 11–15, 2018. San Antonio, TX.

Borghoff S, Wikoff D, Urban JD, Rager JE. A systematic approach to identify plausible mode-of-actions (MOA) for an increased incidence of lung tumors in mice with chronic exposure to 4-methylimidazole (4-MEI). Society of Toxicology Annual Meeting. March 11–15, 2018. San Antonio, TX.

Wikoff DS, Miller GW. 2018. Systematic reviews in toxicology (Editorial). Toxicol Sci 163(2):335–337.

Proctor DM. Hexavalent chromium in drinking water: When is the science sufficient to deviate from defaults? Invited Speaker, Genetic and Environmental Toxicology Association (GETA).  Thresholds in Toxicology and Risk Assessment Fall Symposium.  Oakland, CA,November 14, 2018.

Thompson CM, Wolf JC, Suh M, Proctor DM, Haws LC, Harris MA. Toxicity and recovery in the duodenum of B6C3F1 mice following treatment with intestinal carcinogens; captan, folpet, and hexavalent chromium: Evidence for an adverse outcome pathway. Society of Toxicology Annual Meeting, San Antonio, TX, March 11-15, 2018

Thompson CM, Suh M, Proctor DM, Harris MA. Ten factors for considering the mode of action of Cr(VI)-induced intestinal tumors in rodents. Society of Toxicology Annual Meeting, San Antonio, TX, March 11-15, 2018.

Proctor, DM. Updating the regulatory risk assessment for hexavalent chromium in California: Implications for regulatory standards. Association of Environmental Health Sciences San Diego, CA, March 20, 2018.

Thompson CT, Suh M, Chappell G, Borghoff S, Ellis-Hutchings, R, Wiench, K, Finch, L, Proctor, DM. 2018. Assessment of the mode of action underlying development of forestomach tumors in rodents following oral exposure to ethyl acrylate and relevance to humans. Regul Toxicol Pharmacol 96:178–189 doi: 10.1016/j.yrtph.2018.05.006.

Suh M, Proctor DM, Chappell G, Rager JE, Thompson CM, Borghoff S, Finch L, Ellis-Hutchings R, Wiench K. 2018. A review of the genotoxic, mutagenic, and carcinogenic potentials of several lower acrylates. Toxicology 402-403:50-67, doi: 10.1016/j.tox.2018.04.006.

Proctor DM, Suh M, Chappell G, Borghoff SJ, Thompson CM, Wiench K, Finch L, Ellis-Hutchings R. 2018. An adverse outcome pathway (AOP) for forestomach tumors induced by non-genotoxic initiating events. Regul Toxicol Pharmacol, 96:30-40, doi: 10.1016/j.yrtph.2018.04.016.

Sheridan ER, Jackson M, Paleja A, Martini C, Rashid A, Lea I, Fostel J. Improved searching in the Chemical Effects in Biological Systems (CEBS) database leads to greater utility of NTP data. Presented at the 57th Annual Meeting of Society of Toxicology, San Antonio, TX, March 2018. Abstract 2525-P887.

Lea IA, Borghoff S, Travlos GS. 2018. Electrolytes, blood gases and acid-base balance. In: Kurtz DM, Travlos GS (eds): The Clinical Chemistry of Laboratory Animals (3rd edition). CRC Press, Boca Raton, FL (https://doi.org/10.1201/9781315155807).

Brorby GP. 2018. The ongoing controversy surrounding the effects of short-term exposure to trichloroethene. Presented at the Association for Environmental Health and Sciences Foundation Annual International Conference, March 19–22, San Diego, CA.

Thompson CM, Kirman CR, Hays SM, Suh M, Harvey SE, Proctor DM, Rager JE, Haws LC, Harris MA. 2018. Integration of mechanistic and pharmacokinetic information to derive oral reference dose and margin-of-exposure values for hexavalent chromium. J Appl Toxicol 38:351–365. doi: 10.1002/jat.3545.

Verougstraete V, Henderson R, Mackie C, Newson T, Oller A. 2018. Human health (toxicity) assessment of complex inorganic materials. In: Verougstraete V (ed), Risk Management of Complex Inorganic Materials. Elsevier Inc. ISBN 978-0-12-811063-8.

Wikoff D, Urban JD, Harvey S, Haws LC. 2018. Role of risk of bias in systematic review for chemical risk assessment: A case study in understanding the relationship between congenital heart defects and exposures to trichloroethylene. Int J Toxicol, DOI: 0.1177/1091581818754330.

Lansita J,  Mease KM, Qiu H, Yednock T, Sankaranarayanan S, Kramer S. 2017. Nonclinical development of ANX005: A humanized anti-Clq antibody for treatment of autoimmune and neurodegenerative diseases. Int J Toxicol 1-14. DOI: 10.1177/1091581817740873.

Rager JE, Auerbach SS, Chappell GA, Martin E, Thompson C, Fry RC. 2017. Benchmark dose modeling estimates of the concentrations of inorganic arsenic that induce changes to the neonatal transcriptome, proteome, and epigenome in a pregnancy cohort. Chem Res Toxicol 30(10):1911-1920; DOI: 10.1021/acs.chemrestox.7b00221.

Thompson CM, Suh M, Proctor DM, Haws LC, Harris MA. 2017. Ten factors for considering the mode of action of Cr(VI)-induced gastrointestinal tumors in rodents. Mutation Res 823:45-57.

Thompson CM, Young RR, Dinesdurage H, Suh M, Harris MA, Rohr AC, Proctor DM. 2017. Assessment of the mutagenic potential of hexavalent chromium in the duodenum of Big Blue® rats. Toxicol Appl Pharmacol 330(1):48-52.

Wikoff DS, Rager JE, Harvey S, Haws L, Chappell G, Borghoff S. Development and refinement of a framework for quantitative consideration of study quality and relevance in the evaluation of mechanistic data based on Key Characteristics of Carcinogens. Society of Risk Analysis Annual Meeting. December 10-14, 2017. Arlington, VA.

Wikoff DS, Welsh BT, Henderson R, Brorby G, Britt J, Myers E, Goldberger J, Lieberman HR, O’Brien C, Doepker C. Application of systematic reviews in the evaluation of caffeine safety: Potential adverse effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children. Society of Risk Analysis Annual Meeting. December 10-14, 2017. Arlington, VA.

Chappell GA, Rager JE. 2017. Epigenetics in chemical-induced genotoxic carcinogenesis. Current Opinion Toxicol 6:10-17.

Bichteler A, Wikoff DS, Loko F, Harris MA. 2017. Estimating serum concentrations of dioxin-like compounds in the U.S. population effective 2005-2006 and 2007-2008: A multiple imputation and trending approach incorporating NHANES pooled sample data. Environ Int 105(2017):112-125.

Hoffmann S, de Vries RB, Stephens ML, Beck NB, Dirven HAAM, Fowle III JR, Goodman JE, Hartung T, Kimber I, Lalu MM, Thayer K, Whaley P, Wikoff D, Tsaioun K. 2017. A primer on systematic reviews in toxicology. Arch Toxicol DOI: 10.1007/s00204-017-1980-3.

Rager JE, Ring CL, Fry RC, Suh M, Proctor DM, Haws L, Harris MA, Thompson CM. 2017. High-throughput screening data interpretation in the context of in vivo transcriptomic responses to oral Cr(VI) exposure. Toxicol Sci 158(1):199–212. https://doi.org/10.1093/toxsci/kfx085

Wikoff D, Welsh BT, Henderson R, Brorby GP, Britt J, Myers E, Goldberger J, Lieberman HR, O’Brian C, Peck J, Tenebein M, Weaver C, Harvey S, Urban J, Doepker C. 2017. Systematic review of the potential adverse effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children. Food Chem Toxicol 109(Pt1):585-648. https://doi.org/10.1016/j.fct.2017.04.002.

Lea I, Yang L, Rashid A, Fostel JM. Chemical Effects in Biological Systems (CEBS) Database: Treatment-related findings. Presented at the 56th Annual Meeting of Society of Toxicology, Baltimore, MD, March 2017. Abstract 2918-P412.

Martini C, Rashid A, Paleja A, Lea I, Fostel JM. Chemical Effects in Biological Systems (CEBS) database: Treatment-related findings. Presented at the 56th Annual Meeting of Society of Toxicology, Baltimore, MD, March 2017. Abstract 1381-P119.

Sheridan E, Martini C, Shaw M, Shockley K, Brix A, Rashid A, Lea I, Fostel J. Using the Chemical Effects in Biological Systems (CEBS) database to answer pathology questions. Presented at the 36th Annual Symposium of Society for Toxicologic Pathology, Montreal, Quebec, Canada, June 2017. Poster P035.

Jackson M, Yang L, Yauk CL, Lea I, Kuo B, Williams A, Rashid A, Fostel J. The TGx-28.65 biomarker — A web-based application using transcriptomics to identify DNA damage-inducing chemicals. Presented at the 48th Annual Meeting of Environmental Mutagenesis and Genomics Society, Raleigh, NC, September 2017. Abstract 1224.

Kirman CR, Suh M, Proctor DM, Hays SM. 2017. Improved physiologically based pharmacokinetic model for oral exposures to chromium in mice, rats, and humans to address temporal variation and sensitive populations. Toxicol Appl Pharmacol 325:9-17.

Wikoff DS, Rager J, Harvey S, Haws L, Chappell G, Borghoff S. 2017. Framework for quantitative consideration of study quality and relevance in the systematic evaluation of mechanistic data per the Ten Key Characteristics of Carcinogens. Poster presented at Society of Toxicology Annual Meeting, March 15, Baltimore, MD.

Lea IA, Gong H, Paleja A, Rashid, A, Foster J. 2017. CEBS: A comprehensive annotated database of toxicological data. Nucleic Acids Res 45(D1):D964–D971.

Jackson MA, Yang L, Lea I, Rashid A, Kuo B, Williams A, Lyn Yauk C, Fostel J. 2017. The TGx-28 65 biomarker online application for analysis of transcriptomics data to identify DNA damage-inducing chemicals in human cell cultures. Environ Mol Mutagen 58(7):529–535.

Welsh BT, Todorovic J, Kirson D, Allen HM, Bayly MD, Mihic SJ. 2017. Disruption of a putative intersubunit electrostatic bond enhances agonist efficacy at the human α1 glycine receptor. Brain Res 1657:148-155. 

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Mease K, Kimzey A, Lansita J. 2017. Biomarkers for nonclinical infusion reactions in marketed biotherapeutics and considerations for study design. Curr Opin Toxicol (4:1–15).

Doepker D, Tyndall K, Lane R, Wikoff D, Thompson C, Harvey S, Schmitt D. 2017. A proposed ADI for nitrate. Poster presented at Society of Toxicology Annual Meeting, March 16, Baltimore, MD.

Borghoff SJ, Ring C, Banton MI, Leavens TL. 2017. Ethyl tertiary butyl ether (ETBE) and tertiary butyl alcohol (TBA) physiologically based pharmacokinetic (PBPK) model in rats: Contribution of binding to ?2u-globulin and non-linear kinetics to kidney and liver responses in rats. Poster presented at Society of Toxicology Annual Meeting, March 16, Baltimore, MD.

Thompson C, Rager J, Suh M, Proctor D, Haws L, Harris M. 2017. Mechanistic support for nonlinear risk assessment of rat oral cavity tumors induced by exposure to Cr(VI) in drinking water. Poster presented at Society of Toxicology Annual Meeting. March 15, Baltimore, MD.

Chappell G, Welsh B, Harvey S, Harris M, Wikoff D. 2017. Validation and application of a text mining tool in the identification and categorization of mechanistic data: A case study in improving problem formulation of carcinogenicity assessments. Poster presented at Society of Toxicology Annual Meeting, March 15, Baltimore, MD.

Proctor DM, Suh M, Dunsmore D, Verwiel A, Casteel S. 2017. Bioaccessibility and relative oral bioavailability of cobalt and nickel from metal alloys in soil and dust. Poster presented at Society of Toxicology Annual Meeting, March 15, Baltimore, MD.

Kirman CR, Proctor D, Suh M, Haws L, Harris M, Thompson C, Hays S. 2017. Using physiologically based pharmacokinetic modeling to address potentially sensitive subpopulations exposed to hexavalent chromium. Poster presented at Society of Toxicology Annual Meeting, March 15, Baltimore, MD.

Rager JE, Thompson CM, Ring C, Fry RC, Harris MA. 2017. Integration of transcriptomics and high-throughput screening predictions with robust in vivo data to inform hexavalent chromium mode of action. Poster presented at Society of Toxicology Annual Meeting, March 14, Baltimore, MD.

Thompson C, Kirman C, Suh M, Proctor D, Haws L, Harris M, Hays S. 2017. Risk assessment of oral exposure to Cr(VI): Integration of mode of action, pharmacokinetics, and dose-response modeling. Poster presented at Society of Toxicology Annual Meeting, March 14, Baltimore, MD.

Mease K, Kimzey A, Lansita J. 2017. Failed dose formulation analysis during a GLP study — Now what? Poster presented at Society of Toxicology Annual Meeting, March 14, Baltimore, MD.

Suh M, Harvey S, Wikoff D, Mittal L, Ring C, Goodmanson A, Proctor D. 2017. Meta-analysis of hexavalent chromium and stomach cancer. Poster presented at Society of Toxicology Annual Meeting, March 13, Baltimore, MD.

Thompson CM, Wolf, JC, McCoy A, Suh M, Proctor DM, Kirman CR, Haws LC, Harris MA. 2017. Comparison of toxicity and recovery in the duodenum of B6C3F1 mice following treatment with intestinal carcinogens captan, folpet, and hexavalent chromium. Toxicol Pathol 45(8):1091–1101. DOI: 10.1177/019262331yy4324.

Rish W, Pfau EJ. 2017. Bounding analysis of drinking water health risks from a spill of hydraulic fracturing flowback water. Risk Analysis 38(4):724-754, DOI: 10.1111/risa.12884.

Thompson CM, Bichteler A, Rager JE, Suh M, Proctor DM, Haws LC, Harris MA. 2016. Comparison of in vivo genotoxic and carcinogenic potency to augment mode of action analysis: Case study with hexavalent chromium. Mut Res/Genetic Toxicol Environ Mutagen 800-801:28-34.

Bichteler A. 2016. Constrained multiple imputation: A case study in estimation and modeling on data missing below the limit of detection. Presented in the “Melding Dose-Response Relationships” session at the Society of Risk Analysis, December 14, San Diego, CA.

Wikoff D, Suh M, Harvey S, Proctor D, Beretvas T, Goodman M, Lipworth L. 2016. Systematic review and meta-analysis of occupational exposure to Cr(VI) and stomach cancer. PROSPERO 2016:CRD42016051625 Available from http://www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42016051625

Thompson CM, Rager JE, Suh M, Ring CL, Proctor DM, Haws LC, Fry RC, Harris MA. 2016. Transcriptomic responses in the oral cavity of F344 rats and B6C3F1 mice following exposure to Cr(VI): Implications for risk assessment. Environ Molec Mutagen 57:706-716.

De Flora S, Camoirano A, Micale RT, La Maestra S, Savarino V, Zentilin P, Marabotto E, Suh M, Proctor DM. 2016. Reduction of hexavalent chromium by fasted and fed human gastric fluid.  I. Chemical reduction and mitigation of mutagenicity. Toxicol Appl Pharmacol   306:113-119.

Rager J, Thompson C, Auerbach S, Fry R. 2016. Integrating genomic and epigenomic data into risk assessment applications through dose response modeling: Case study with prenatal arsenic exposure. Environmental Mutagenesis and Genomics Society, September 25, Kansas City, KS. 

Borghoff SJ, Ring C, Banton M, Leavens TL. 2016. Physiologically based pharmacokinetic model for ethyl tertiary-butyl ether and tertiary-butyl alcohol in rats: Contribution of binding to a2u-globulin in male rats and high-exposure nonlinear kinetics to toxicity and cancer outcomes.  J Appl Toxicol, DOI 10.1002/jat.3412

Wikoff D, Borghoff S, Rager J, Harvey S, Haws L. 2016. A systematic review of the mechanistic evidence of tetrabromobisphenol TBBPA as a human carcinogen according to the ten key characteristics of carcinogens (TKCC) identified by Smith et al. (2016). PROSPERO 2016:CRD42016046429 Available from:  http://www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42016046429

Haws L. 2016. Vapor intrusion – Solid ground or quick sand? Invited Speaker. Presented at the 28th Annual Texas Environmental Superconference, August 5, Austin, TX.

Haws L. 2016. Vapor intrusion – Technical issues. Invited Speaker. Presented at the Semi-Annual South Central Regional Meeting of the Auditing Roundtable, August 3, Austin, TX.

Thompson CM, Suh M, Mittal L, Wikoff D, Welsh B, Proctor DM. 2016. Development of linear and threshold no significant risk levels for inhalation exposure to titanium dioxide using systematic review and mode of action considerations. Regul Toxicol Pharmacol 80:60-70.

Borghoff SJ. 2016. Organization and review of mechanistic data according to “Ten Key Characteristics of Carcinogens” (TKCC) {Smith et al., 2016}. Presented at the 42^nd Annual Summer Meeting of the Toxicology Forum, July, Salt Lake City, UT.

Suh M, Thompson CM, Brorby GP, Mittal L, Proctor DM. 2016. Inhalation cancer risk assessment of cobalt metal. Regul Toxicol Pharm 79(2016):74-82.

Kirman CR, Suh M, Hays SM, Gürleyük H, Gerads R, De Flora S, Parker W, Lin S, Haws LC, Harris MA, Proctor DM. 2016. Reduction of hexavalent chromium by fasted and fed human gastric fluid.  II. Ex vivo gastric reduction modeling. Toxicol Appl Pharmacol 306:120-133.

Haws L. 2016. Trichlorethylene exposure and development of fetal cardiac malformations: What do the data tell us about inhalation exposures resulting from vapor intrusion and potential health risks to pregnant women? – Introduction. Presented at the Society of Toxicology’s 55th Annual Meeting, March 13-17, New Orleans, LA.

Proctor DM. 2016. Cancer risk assessment for ingested hexavalent chromium:  Challenges and controversies – Introduction. Presented at the Society of Toxicology’s 55th Annual Meeting, March 13-17, New Orleans, LA [session introduction; no abstract].

Wikoff D, Borghoff SJ, Rager JE, Haws LC. 2016. Human relevance assessment of tetrabromobisphenol-A (TBBPA) induced uterine adenocarcinomas: Mode of action dependent on high dose molecular initiating event (MIE). Presented in the “Flame Retardants” session at the Society of Toxicology’s 55th Annual Meeting, March 13-17, New Orleans, LA.

Suh M. 2016. Cumulative risk assessment of urban air toxics: A pilot study in San Antonio, Texas. Presented in the “Quantitative Cumulative Risk Assessment: Is it Feasible Today?” Session of the Society of Toxicology’s 55th Annual Meeting, March 13-17, New Orleans, LA.

Thompson CM. 2016. Non-mutagenic MOA for Cr(VI) involving intestinal cytotoxicity and regenerative hyperplasia. Platform presentation in the “The Cancer Risk Assessment for Ingested Hexavalent Chromium: Challenges and Controversies” Session. Presented at the Society of Toxicology’s 55th Annual Meeting, March 13-17, New Orleans, LA.

Borghoff SJ,  Wikoff D, Rager JE, Haws LC. 2016. Tetrabromobisphenol A (TBBPA); Dose- and time-dependent changes in plasma TBBPA and its conjugates over 28 days of administration. Presented at the Society of Toxicology’s 55th Annual Meeting, March 13-17, 2016. New Orleans, LA.

DeVito MJ, Borghoff SJ, Zorilla LM, Shockley K, Kissling G,  Travlos G. 2016. The effects of a high fat (HF) diet on male diversity outbred (DO) mice. Presented at the Society of Toxicology’s 55th Annual Meeting, March 13-17, New Orleans, LA.

Cullen JM, Ward JM, Thompson CM. 2016. Re-evaluation and classification of duodenal lesions in B6C3F1 mice and F344 rats from four studies of hexavalent chromium in drinking water. Presented at the Society of Toxicology’s 55th Annual Meeting, March 13-17, New Orleans, LA.

Thompson CM, Suh M, Proctor DM, Rager JE, Haws LC, and Harris MA. 2016. Assessment of the in vivo genotoxicity of CrVI in target organs identified in a two-year cancer bioassay. Presented at the Society of Toxicology’s 55th Annual Meeting, March 13-17, New Orleans, LA.

Suh M, Crump K, Mittal L, Hirsch S, Valdes Salgado R, BartlettC, Van Landingham C, Rohr A, Proctor DM. 2016. Inhalation cancer risk assessment of hexavalent chromium based on updated mortality for Painesville chromate production workers. Presented at the Society of Toxicology’s 55th Annual Meeting, March 13-17, New Orleans, LA.

Brorby GP, Suh M, Thompson CM, Mittal L, Proctor DM. 2016. Inhalation cancer risk assessment of cobalt metal. Presented at the Society of Toxicology’s 55th Annual Meeting, March 13-17, New Orleans, LA.

Verwiel A, Proctor D, Tachovsky A. 2016. Principal component analysis of metals in soil and dust to distinguish background and anthropogenic sources in an urban area. Association for Environmental Health and Sciences Foundation Annual Meeting, March 14, San Diego, CA.

Cullen JM, Ward JM, Thompson CM. 2016. Reevaluation and classification of duodenal lesions in B6C3F1 mice and F344 rats from 4 studies of hexavalent chromium in drinking water. Toxicologic Pathol 44(2):279-89.

Wikoff DS, Britt JK.  2016. The role of systematic review in the practice of toxicology and risk assessment – An appreciation for the primary tool in evidence-based approaches.  Toxicology: Open Access 2(110):1-4. 

Wikoff DS, Rager JE, Haws LC, Borghoff SJ. 2016. A high dose mode of action for tetrabromobisphenol A-induced uterine adenocarcinomas in Wistar Han rats: A critical evaluation of key events in an adverse outcome pathway framework. Regul Toxicol Pharmacol 77:143-159. doi: 10.1016/j.yrtph.2016.01.018

Hanlon P, Brorby GP, Krishan M. 2016. A risk-based strategy for evaluating mitigation options for processed-formed compounds in food: Workshop proceedings. Int J Toxicol 35(3):358–370.

Schmitt D, Levy R, Carroll B. 2016. Toxicological evaluation of ß-caryophyllene oil: Subchronic toxicity in rats. Int J Toxicol 35(5):558–567.

Borghoff SJ, Wikoff D, Harvey S, Haws L. 2016. Dose- and time-dependent changes in tissue levels of tetrabromobisphenol A (TBBPA) and its sulfate and glucuronide conjugates following repeated administration to female Wistar Han Rats. Toxicol Rep 3:190-201. doi:10.1016/j.toxrep.2016.01.007

Doepker C, Lieberman HR, Smith AP, Peck JD, El-Sohemy A, Welsh BT. 2016. Caffeine: Friend or Foe? Annu Rev Food Sci Technol. DOI: 10.1146/annurev-food-041715-033243

Proctor DM, Suh M, Mittal L, Hirsch S, Salgado RV, Bartlett C, Van Landingham C, Rohr A, Crump K. 2015. Inhalation cancer risk assessment of hexavalent chromium based on updated mortality for Painesville chromate production workers. J Expo Sci Environ Epidemiol 26(2):224-231. doi: 10.1038/jes.2015.77.

James RC, Britt JK, Halmes NC, Guzelian PS. 2015. Evidence-based causation in toxicology: A 10-year retrospective. Hum Exp Toxicol 34(12):1245–1252.

Wikoff D, Doepker C, Welsh B, Urban J, Henderson R, Britt J, Harvey S, Goldberger J, Myers E, O’Brien C, Peck J, Lieberman H, Weaver C, Tenebein M. 2015. Systematic review of the adverse bone and calcium balance effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children. PROSPERO 2015:CRD42015026609 Available from http://www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42015026609 (Systematic Review Protocol Registration)

Wikoff D, Doepker C, Welsh B, Urban J, Henderson R, Brorby G, Britt J, Harvey S, Goldberger J, Myers E, O’Brien C, Peck J, Lieberman H, Weaver C, Tenebein M. 2015. Systematic review of the adverse cardiovascular effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children. PROSPERO 2015:CRD42015026673 Available from http://www.crd.york.ac.uk/PROSPERO/display_record. asp?ID=CRD42015026673 (Systematic Review Protocol Registration)

Lansita JA, Burke JM, Apgar JF, Mounho-Zamora B. 2015. An introduction to the regulatory and nonclinical aspects of the nonclinical development of antibody drug conjugates. Pharmceut Res 32(11):3584-3592. DOI 10.1007/s11095-015-1742-y

Hughes BJ, LeBaron MJ, Thomas J, Kan HL, Lynch AM, Borghoff SJ, Green S, Mensing T, Sarang SS, Smulders CJGM. 2015. Activation of CAR and PXR nuclear receptors in the liver of MIBK-exposed mice. Presented at the Society of Toxicology’s 54th Annual Meeting, March 22-26, 2015. San Diego, CA.

Kirman CR, Proctor DM, Suh M, Hays S. 2015. Reduction of hexavalent chromium by gastric fluids from fed and fasted individuals with applications to toxicokinetic modeling. Presented at the Society of Toxicology’s 54th Annual Meeting, March 22-26, San Diego, CA.

Suh M, Mittal L, Hirsch S, Valdes R, Bartlett C, Rohr A, Proctor D. 2015. Lung cancer risk in chromate production workers exposed to hexavalent chromium. Presented at the Society of Toxicology’s 54th Annual Meeting, March 22-26, San Diego, CA.

Britt J, James R. 2015. Welding and occupational exposure to manganese fumes and Parkinson’s disease:  An evidence-based causation analysis. Presented at the Society of Toxicology’s 54th Annual Meeting, March 22-26, San Diego, CA.

Mounho-Zamora B, Weissman I, Volkmer J, Willingham S, Prohaska S, Howard M, Jie L, Majeti R.2015.  Nonclinical safety assessment of a monoclonal antibody against CD47. Presented at the Society of Toxicology’s 54th Annual Meeting, March 22-26, San Diego, CA.

Doepker C, Brorby G. 2015. The role of the toxicologist in required food safety plans:  A case study of ochratoxin A (OTA) in coffee. Presented at the Society of Toxicology’s 54th Annual Meeting, March 22-26, San Diego, CA.

Proctor D, Suh M, Thompson C, Hixon, G. 2015. Inhalation cancer risk assessment of titanium dioxide. Presented at the Society of Toxicology’s 54th Annual Meeting, March 22-26, San Diego, CA.

Urban JD, Thompson CM, Plunkett LM, Perry CS, Haws LC. 2015. A state of the science copper reference dose for soil remediation. Presented at the Society of Toxicology’s 54th Annual Meeting, March 22-26, San Diego, CA.

Harris MA, Thompson CM, Proctor DM, Suh M, Wolf JC, Seiter JM, Chappell MA, Haws LC. 2015. Analysis of duodenal crypt health following exposure to Cr(VI) in drinking water. Presented at the Society of Toxicology’s 54th Annual Meeting, March 22-26, San Diego, CA.

Thompson CM, Young RR, Suh M, Dinesdurage H, Elbekai R, Harris MA, Rohr AC, Proctor DM. 2015. Hexavalent chromium does not induce mutations in the oral mucosa of transgenic Big Blue® rats following drinking water exposures at a carcinogenic dose. Presented at the Society of Toxicology’s 54th Annual Meeting, March 22-26, San Diego, CA.

Thompson CM, Suh M, Hixon G, Bichteler A. 2015. Comparison of smoothing spline regression and conventional modeling approaches for quantitative risk sssessments of human dioxin exposure. Presented at the Society of Toxicology’s 54th Annual Meeting, March 22-26, San Diego, CA.

Borghoff SJ, Wikoff D, White MC, Thompson C, Haws LC. 2015. Identification of the molecular initiating event (MIE) for TBBPA induced uterine tumors in the framework of an adverse outcome pathway (AOP). Presented at the Society of Toxicology’s 54th Annual Meeting, March 22-26, San Diego, CA.

Wikoff D, White MC, Borghoff SJ, Haws LC. 2015. Evaluation of tetrabromobisphenol A (TBBPA)-induced endocrine-related target gene activity using high-throughput screening data from ToxCast. Presented at the Society of Toxicology’s 54th Annual Meeting, March 22-26, San Diego, CA.

Thompson CM, Wolf JC, Elbekai RH, Paranjpe MG, Seiter JM, Chappell MA, Tappero RV, Suh M, Proctor DM, Bichteler A, Haws LC, Harris MA. 2015. Duodenal crypt health following exposure to Cr(VI): Micronucleus scoring, γ-H2AX immunostaining, and synchrotron x-ray fluorescence microscopy. Mut Res 789–790:61–66.

Thompson CM, Young RR, Suh M, Dinesdurage HR, Elbekai RH, Harris MA, Rohr AC, Proctor DM. 2015. Assessment of the mutagenic potential of Cr(VI) in the oral mucosa of Big Blue® transgenic F344 rats. Environ Mol Mutagen 56:621-628.

James RC, Roberts SM, Williams PL. 2015. General principles of toxicology. In: Principles of Toxicology: Environmental and Industrial Applications, 3rd Edition. John Wiley and Sons, New York.

Young RR, Thompson CM, Dinesdurage HR, Elbekai RH, Suh M, Rohr AC, Proctor DM. 2015. A robust method for assessing chemically induced mutagenic effects in the oral cavity of transgenic Big Blue® rats. Environ Mol Mutagen 56:629-636.

James RC, Roberts SM. 2015. Hepatoxicity: Toxic effects on the liver. In: Principles of Toxicology: Environmental and Industrial Applications, 3rd Edition. John Wiley and Sons, New York, NY.

Stuchal LD, James RC, Roberts SM. 2015. Human health risk assessment. In: Principles Principles of Toxicology: Environmental and Industrial Applications, 3rd Edition. John Wiley and Sons, New York, NY.

Borghoff SJ, Poet TS, Green S, Davis J, Hughes B, Mensing T, Sarang SS, Lynch AM, Hard GC.  2015. Methyl isobutyl ketone exposure-related increases in specific measures of α2u-globulin (α2u) nephropathy in male rats along with in vitro evidence of reversible protein binding. Toxicology 333(2015):1-13.

Lansita JA, Mounho-Zamora B. 2015. The development of therapeutic monoclonal antibodies:  Overview of the nonclinical safety assessment. Curr Pain Headache Rep 19(3):472.

Britt JK. 2015. Properties and effects of pesticides. In: Principles of Toxicology: Environmental and Industrial Applications, 3rd Edition. John Wiley and Sons, New York.

Urban JD, Carakostas MC, Taylor SL. 2015. Steviol glycoside safety: Are highly purified steviol glycoside sweeteners food allergens? Food Chem Toxicol 75: 71-78.

Thompson CM, Seiter J, Chappell MA, Tappero RV, Proctor DM, Suh M, Wolf JC, Haws LC, Vitale R, Mittal L, Kirman CR, Hays SM, Harris MA. 2015. Synchrotron-based imaging of chromium and γ-H2AX immunostaining in the duodenum following repeated exposure to Cr(VI) in drinking water. Toxicol Sci 143(1): 16-25.

Lea I, Rashid A, Favaro C, Fostel J. Chemical Effects in Biological Systems (CEBS) database: Advanced histopathology search applications. Presented at the 54th Annual Meeting of Society of Toxicology, San Diego, CA, March 2015. Abstract 2195-P410.

Ramani T, Auletta CS, Weinstock D, Mounho-Zamora B, Ryan PC, Salcedo TW, Bannish G. 2015. Cytokines: The good, the bad, and the deadly. Int J Toxicol 34(4):355–365, DOI 10.1177/1091581815584918.

Wikoff D, Doepker C, Welsh B, Goldberger J, Lieberman H, Myers E, O’Brien C, Peck J, Tenebein M, Weaver C. Systematic review of the adverse behavioral effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children. PROSPERO 2015:CRD42015027413 Available from http://www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42015027413 (Systematic Review Protocol Registration)

Wikoff D, Doepker C, Welsh B, Harvey S, Goldberger J, Lieberman H, Myers E, O’Brien C, Peck J, Tenebein M, Urban J, Weaver C. Systematic review of the adverse reproductive and developmental effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children. PROSPERO 2015:CRD42015026736 Available from http://www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42015026736 (Systematic Review Protocol Registration)

Wikoff D, Doepker C, Welsh B, Harvey S, Goldberger J, Lieberman H, Myers E, O’Brien C, Peck J, Tenebein M, Urban J, Weaver C. Systematic review of acute adverse effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children. PROSPERO 2015:CRD42015026704 Available from http://www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42015026704 (Systematic Review Protocol Registration)

Wikoff D, Thompson C, Perry C, White M, Borghoff S, Fitzgerald L, Haws LC. 2014. Development of toxicity values and exposure estimates for tetrabromobisphenol A [TBBPA]: Application in a margin of exposure assessment. J Appl Toxicol 35(11):1292-1308. doi: 10.1002/jat.3132.

Fitzgerald L, Wikoff DS. 2014. Persistent organic pollutants. In: Wexler P (Ed.), Encyclopedia of Toxicology, 3rd edition, vol 3. Elsevier, Inc., Academic Press, pp. 820-825.

Borghoff SJ, Hard GC, Poet TS, Davis J, Green S, Hughes B, Mensing T, Sarang SS. 2014. Methyl isobutyl ketone (MIBK) induces an exposure-related increase in measures of a2u-globulin (a2u) nephropath in male but not female F344 rats. Presented at the Society of Toxicology’s 53rd Annual Meeting, March 23-27, Phoenix, AZ.

Haws LC, Thompson C, Perry C, White M, Fitzgerald L, Borghoff S, Wikoff D. 2014. Development of non-cancer based toxicity factors and daily dose estimates for TBBPA. Presented at the Society of Toxicology’s 53rd Annual Meeting, March 23-27, Phoenix, AZ.

Kerger BD, James RC, Galbraith DA. 2014. Tumors that mimic asbestos-related mesothelioma: Time to consider a genetics-based tumor registry? Frontiers in Genetics 5(151):1-14.

Kirman CR, Proctor D, Suh M, Thompson CM, Harris MA, Haws LC, Hays SM. 2014. Variation analysis of PBPK model parameters for describing the delivery of Cr(VI) to the small intestines of humans. Presented at the Society of Toxicology’s 53rd Annual Meeting, March 23-27, Phoenix, AZ.

Hays SM, Kirman CR, Suh M, Proctor DM.  2014. Gastric reduction of hexavalent chromium [Cr(VI)] in fed and fasted human stomach samples. Presented at the Society of Toxicology’s 53rd Annual Meeting, March 23-27, Phoenix, AZ.

Proctor DM, Suh M. Campleman SL, Thompson CM. 2014. Assessment of the mode of action for hexavalent chromium-induced lung cancer following inhalation exposures. Toxicology 325:160-179.

Henderson R, Verougstraete V, Anderson K, Arbildua JJ, Brock TO, Brouwers T, Cappellini D, Delbeke K, Herting G, Hixon G, Odnevall Wallinder I, Rodriguez PH, Van Assche F, Wilrich P, Oller AR. 2014. Inter-laboratory validation of bioaccessibility testing for metals. Presented at the Society of Toxicology’s 53rd Annual Meeting, March 23-27, Phoenix, AZ.

Johnson GE, Soeteman-Hernandez, Gollapudi BB, Bodger OG, Dearfield KL, RH Heflich, Hixon JG, Lovell DP, MacGregor JT, Pottenger LH, Thompson CM, Abraham L, Thybaud V, Tanir JY, Zeiger E, van Benthem J, White PA. 2014. Derivation of point of departure (PoD) estimates in genetic toxicology studies and their potential applications in risk assessment. Environ Molec Mutagen 55(8):609-623. doi: 10.1002/em.21870/em.21870.

Hixon JG, Thompson C, Bichteler A, Abraham L. 2014. Smoothing regression splines as the basis for dose-response modeling. Presented at the Society of Toxicology’s 53rd Annual Meeting, March 23-27, Phoenix, AZ.

Henderson R, Verougstraete V, Anderson K, Arbildua JJ, Brock TO, Brouwers T, Cappellini D, Delbeke K, Herting G, Hixon G, Wallinder IO, Rodriguez PH, Assche FV, Wilrich P, Oller AR. 2014. Interlaboratory validation of bioaccessibility testing for metals. Regul Toxicol Pharmacol 70(1):170-181. doi: 10.1016/j.yrtph.2014.06.02.

Proctor DM, Suh M, Tachovsky JA, Abraham L, Hixon JG, Brorby GP, Campleman SL. 2014. Cumulative risk assessment of urban air toxics: A pilot study in San Antonio, Texas. Presented at the Society of Toxicology’s 53rd Annual Meeting, March 23-27, Phoenix, AZ.

Faber W, Kirkpatrick D, Coder P, Li P, Borghoff S, Banton M. 2014. Subchronic, reproductive, and maternal toxicity studies with tertiary butyl acetate (TBAC). Regul Toxicol Pharmacol 68:332-342.

Suh M, Yzenas JJ, Proctor DM. 2014. Evaluation of electric arc furnace-processed steel slag for dermal corrosion, irritation, and sensitization. Presented at the Society of Toxicology’s 53rd Annual Meeting, March 23-27, Phoenix, AZ.

James RC, Britt J, Halmes N, Guzelian P. 2014. Comments on recent discussions providing differing causation methodologies. Hum Experim Toxicol 33(1):109-112.

Thompson CM, Proctor DM, Suh M, Wolf JC, Haws LC, Seiter JM, Chappell MA, Harris MA. 2014. X-ray fluorescence microspectroscopic analysis of duodenal mucosae following Cr(VI) exposure in drinking water. Presented at the Society of Toxicology’s 53rd Annual Meeting, March 23-27, Phoenix, AZ.

Juberg DR, Borghoff SJ, Becker RA, Casey W, Hartung T, Holsapple MP, Marty MS, Mihaich EM, Van Der Kraak G, Wade MG and others. 2014. t4 Workshop report — Lessons learned, challenges, and opportunities: The U.S. Endocrine Disruptor Screening Program. Altex 31(1):63-78.

Song G, Darr DB, Santos CM, Ross M, Valdivia A, Jordan JL, Midkiff BR, Cohen S, Feinberg NN, Miller CR, Tarrant TK, Rogers AB, Dudley AC, Perou CM, Zamboni WC. 2014. Effects of tumor microenvironment heterogeneity on nanoparticle disposition and efficacy in breast cancer tumor models. Clin Cancer Res 20(23):6083–6095.

Bhusari S, Malarkey DE, Hong HH, Wang Y, Masinde T, Nolan M, Hooth NJ, Lea IA, Vasconcelos D, Sills RC, Hoenerhoff MJ. 2014. Mutation spectra of Kras and Tp53 in urethral and lung neoplasms in B6C3F1 mice treated with 3,3′,4,4′-tetrachloroazobenzene. Toxicol Pathol 42(3):555–564.

Urban JD, Doepker CL, Cuellar-Kingston N, van de Ligt J, Carakostas M. 2014. Do highly purified steviol glycoside sweeteners cause food allergies? Presented at the Society of Toxicology’s 53rd Annual Meeting, March 23-27, Phoenix, AZ.

Suh M, Troese MJ, Hall DA, Yasso B, Yzenas JJ, Proctor DM. 2014. Evaluation of electric arc furnace-processed steel slag for dermal corrosion, irritation, and sensitization from dermal contact. J Appl Toxicol 34(12):1418-1425. DOI: 10.1002/jat.2974.

Wikoff D, Thompson C, Perry C, White M, Fitzgerald L, Borghoff S, Haws LC. Development of an oral cancer slope factor and lifetime average daily dose estimates for TBBPA. Presented at the Society of Toxicology’s 53rd Annual Meeting, March 23-27, 2014. Phoenix, AZ.

Bunch AG, Perry CS, Abraham L, Wikoff DS, Tachovsky JA, Hixon JG, Urban JD, Harris MA, Haws LC. 2014. Evaluation of impact of shale gas operations in the Barnett Shale region on volatile organic compounds in air and potential human health risks. Sci Tot Environ 468-469(2014):832-842.

Suh M, Abraham L, Hixon JG, Proctor D. 2014. The effects of perchlorate, nitrate, and thiocyanate on free thyroxine for potentially sensitive subpopulations of the 2001–2002 and 2007–2008 National Health and Nutrition Examination Surveys. J Expos Sci Epidemiol 24:579-587.

Urban JD, Wikoff DS, Bunch ATG, Harris MA, Haws LC. 2014. A review of background dioxin concentrations in urban/suburban and rural soils across the United States: Implications for site assessments and the establishment of soil cleanup levels. Sci Tot Environ 466-467:586-597.

Thompson CM, Kirman CR, Proctor DM, Haws LC, Suh M, Hays S, Hixon JG, Harris MA. 2014. A chronic oral reference dose for hexavalent chromium-induced intestinal cancer. J Appl Toxicol 34:525-536. doi: 10.1002/jat.2907.

Mahadevan B, Thorsrud BA, Brorby GP, Ferguson HE. 2014. A 3-week dietary safety study of octenyl succinic anhydride (OSA)-modified starch in neonatal farm piglets. Food Chem Toxicol 72:83-89.

Suh M, Thompson C, Kirman C, Carakostas M, Haws LC, Harris M, Proctor D. 2014. High concentrations of hexavalent chromium in drinking water alter iron homeostasis in F344 rats and B6C3F1 mice. Food  Chem Toxicol 65:381-388.

Henderson R, Verougstraete V, Anderson K, Arbildua JJ, Brock TO, Brouwers T, Cappellini D, Delbeke K, Herting G, Hixon G, Odnevall Wallinder I, Rodriguez PH, Van Assche F, Wilrich P, Oller AR. 2013. Interlaboratory comparison of bioaccessibility tests for metals. Annual meeting of the Belgian Society for Toxicology and Ecotoxicology (BelTox).

Mounho-Zamora B. 2013. Regulatory standards for the approval of biosimilar products: A global review. In Weinbauer GF,  Vogel F, eds. Challenges in Nonhuman Primate Research in the 21st Century. Waxmann, pg 9-34.

MacDonell MM, Haroun LA, Teuschler LK, Rice ER, Hertzberg RC, Butler JP, Chang Y, Clark S, Johns AP, Perry CS, Garcia SS, Jacobi JH, Scofield MA. 2013. Cumulative risk assessment toolbox: Methods and approaches for the practitioner. J Toxicol 2013:310904.

Kirman CR, Aylward LL, Suh M, Harris MA, Thompson CM, Haws LC, Proctor DM, Lin SS, Parker W, Hays SM. 2013. Physiologically based pharmacokinetic model for humans orally exposed to chromium. Chem Biol Interact 204(1):13-27. doi:pii: S0009-2797(13)00082-3. 10.1016/j.cbi.2013.04.003.

Lamm SH, Britt JK, James RC. 2013. Multiple myeloma risk and benzene exposure among pliofilm workers – A re-analysis using an internal reference group. Presented at the Society of Toxicology’s 52nd Annual Meeting, March 10-14, San Antonio, TX.

Dourson ML, Gadagbui B, Griffin S, Garabrant DH, Haws LC, Kirman C, Tohyama C. 2013. The importance of problem formulations in risk assessment: A case study involving dioxin-contaminated soil. Regul Toxicol Pharmacol 66(2):208-216.

O’Brien T, Ding H, Suh M, Thompson C, Parsons BL, Harris MA, Winkelman WA, Wolf JC, Hixon JG, Schwartz AM, Myers MB, Haws LC, Proctor DM. 2013. Assessment of K-Ras mutant frequency and micronucleus incidence in the mouse duodenum following 90-days of exposure to Cr(VI) in drinking water. Mutat Res 754:15-21. doi: 10.1016/j.mrgentox.2013.03.008

Wikoff D, Fitzgerald L, Haws L, Harris M. 2013. Health-based framework for evaluating the safety of hydraulic fracturing products. Presented at the Society of Toxicology’s 52nd Annual Meeting, March 10-14, San Antonio, TX.

Rowlands JC, Budinsky R, Gollapudi B, Black MB, Wolfinger RD, Cukovic D, Bombkowski A, Thompson CM, Urban JD, Thomas RS. 2013. A genomics-based analysis of relative potencies of dioxin-like compounds in primary rat hepatocytes. Toxicol Sci 136(2):595-604.

Thompson CM, Proctor DM, Suh M, Haws LC, Kirman CR, Harris MA. 2013. Assessment of the mode of action underlying development of rodent small intestinal tumors following oral exposure to hexavalent chromium and relevance to humans. Crit Rev Toxicol 43(3): 244-274.

Suh M, Thompson CM, Hixon JG, Harris MA, Kirman CR, Hays S Haws LC, Proctor DM. 2013. Potential involvement of oxidative stress and iron disturbance in the development of oral cavity tumors in rats exposed to hexavalent chromium. Presented at the Society of Toxicology’s 52nd Annual Meeting, March 10-14, San Antonio, TX.

Haws L, Hixon G, DeVito M, Walker N, Kuriakose L, Harris M, Birnba0um L, Wikoff D. 2013. Development of weighted distributions of relative potency estimates for dioxin-like compounds. Presented at the Society of Toxicology’s 52nd Annual Meeting, March 10-14, San Antonio, TX.

Urban JD, Thompson CM, Deskin R, Waite M, Haws LC. 2013. Development of an oral cancer slope factor for acrylamide based on tumors relevant to humans. Presented at the Society of Toxicology’s 52nd Annual Meeting, March 10-14, San Antonio, TX.

Brorby GP, Sheehan PJ, Berman DW, Bogen KT, Holm SE. 2013. Exposures from chrysotile-containing joint compound: Evaluation of new model relating respirable dust to fiber concentrations. Risk Analysis 33(1): 161-176.

Thompson CM, Kirman CR, Proctor DM, Suh M, Hays SM, Haws LC, Harris MA. 2013. A chronic oral reference dose for hexavalent chromium. Presented at the Society of Toxicology’s 52nd Annual Meeting, March 10-14, San Antonio, TX.

Urban JD, Carakostas MC, Brusick, DJ. 2013. Steviol glycoside safety: Is the genotoxicity database sufficient? Food Chem Toxicol 51:386-390.

Proctor DM, Suh M, Thompson CM, Harris MA. 2013. Mode of action evaluation for hexavalent chromium-induced lung cancer. Presented at the Society of Toxicology’s 52nd Annual Meeting, March 10-14, San Antonio, TX.

Thompson CM, Gaylor DW, Tachovsky JA, Perry C, Carakostas MC, Haws LC. 2013. Development of a chronic noncancer oral reference dose and drinking water screening level for sulfolane using benchmark dose modeling. J Appl Toxicol 33(12):1395-1406.

Kirman CR, Thompson CM, Proctor DM, Suh M, Haws LC, Harris MA, Hays SM. 2013. Using PBPK modeling to address diurnal variation and age differences in hexavalent chromium toxicokinetics in humans. Presented at the Society of Toxicology’s 52nd Annual Meeting, March 10-14, San Antonio, TX.

Carakostas MC, Prakash I, Kinghorn AD, Wu CD, and Soejarto DD. 2012. Steviol glycosides. In Alternative Sweeteners, 4th ed. Lyn O’Brien Nabors, Taylor and Francis Group LLC, Boca Raton, FL., pg 159-180.

Kirman, CR, Hays, SM, Aylward, LL, Suh, M, Harris, MA, Thompson, CM, Haws, LC, Proctor, DM. 2012. Physiologically based pharmacokinetic model for rats and mice orally exposed to chromium. Chem Biol Interact 200(1):45-64.

Brorby G, Proctor D, Perry C, Fitzgerald L, Tachovsky A. 2012. Probabilistic risk assessment of human exposure to iron and steel slag. Presented at the Society of Toxicology’s 51st Annual Meeting, March 11-15, San Francisco, CA.

Doepker CL, Maier A, Willis A, Hermansky S. 2012. Toxicology of flavors in the food industry. Chapter 7 In: Bingham E, Cohrssen B., eds. Patty’s Toxicology, Sixth ed. New York: Wiley & Sons.

Kopec AK, Thompson CM, Kim S, Forgacs AL, Zacharewski TR. 2012. Comparative toxicogenomic analysis of oral Cr(VI) exposure effects in rat and mouse small intestinal epithelium. Toxicol Appl Pharmacol 262(2):124-138.

Finch G, Mounho B. 2012. Development of biosimilar products: Overview of standards and regulations. Presented at the Society of Toxicology’s 51st Annual Meeting, March 11-15, San Francisco, CA.

Wikoff DW, Fitzgerald L, Birnbaum L. 2012. Persistent organic pollutants: An overview. In: Schecter, A. (ed.), Dioxins and Health Including Other Persistent Organic Pollutants and Endocrine Disruptors, 3rd edition. John Wiley & Sons, Inc., pp. 1-35.

Kopec AK, Kim S, Forgacs AL, Zacharewski TR, Proctor DM, Harris MA, Haws LC, Thompson CM. 2012. Genome-wide gene expression effects in B6C3F1 mouse intestinal epithelia following 7 and 90 days of exposure to hexavalent chromium in drinking water. Toxicol Appl Pharmacol 259(1):13-26.

Harris MA, Thompson CM, Wolf JC, Fedorov Y, Hixon JG, Proctor DM, Suh M, Haws LC. 2012. Assessment of genotoxic potential of Cr(VI) in the intestine via in vivo intestinal micronucleus assay and in vitro high content analysis in differentiated and undifferentiated caco-2. Presented at the Society of Toxicology’s 51st Annual Meeting, March 11-15, San Francisco, CA.

Proctor DM, Suh M, Aylward LL, Kirman CR, Harris MA, Thompson CM, Gürleyük H, Gerads R, Haws LC, Hays SM. 2012. Hexavalent chromium reduction kinetics in rodent stomach contents. Chemosphere 89(5): 487-493.

Haws L, Fitzgerald L, Burkhalter K, Wikoff D. 2012. US EPA’s proposed toxicity values for TCDD: Implications for decision-making regarding the safety of foods in the United States. Presented at the Society of Toxicology’s 51st Annual Meeting, March 11-15, San Francisco, CA.

Thompson CM, Fedorov Y, Brown DD, Suh M, Proctor DM, Kuriakose L, Haws L, Harris MA. 2012. Assessment of Cr(VI)-induced cytotoxicity and genotoxicity using high content analysis. PLoS ONE 7(8): e42720.

Hays SM, Kirman C, Aylward L, Suh M, Proctor D. 2012. Gastric reduction of Cr(VI) in mice, rats and humans. Presented at the Society of Toxicology’s 51st Annual Meeting, March 11-15, San Francisco, CA.

Thompson CM, Hixon JG, Proctor DM, Haws LC, Suh M, Urban JD,  Harris MA. 2012. Assessment of genotoxic potential of Cr(VI) in the mouse duodenum: An in silico comparison with mutagenic and nonmutagenic carcinogens across tissues. Regul Toxicol Pharmacol 64(1): 68-76.

Hixon JG, Proctor D. 2012. Use of constrained logistic regression models for the dose-response analysis of beryllium sensitization and chronic beryllium disease with mean exposure. Presented at the Society of Toxicology’s 51st Annual Meeting, March 11-15, San Francisco, CA.

Thompson CM, Proctor DM, Suh M, Haws LC, Hebert CD, Mann JF, Shertzer HG, Hixon JG, Harris MA. 2012. Comparison of the effects of hexavalent chromium in the alimentary canal of F344 rats and B6C3F1 mice following exposure in drinking water: Implications for carcinogenic modes of action. Toxicol Sci 125(1):79-90.

Kim S, Kopec A, Forgacs AL, Thompson CM, Zacharewski T. 2012. Genome-wide gene expression analysis of Cr(VI) effects in Fisher rat small intestinal epithelium. Presented at the Society of Toxicology’s 51st Annual Meeting, March 11-15, San Francisco, CA.

Thompson CM, Proctor DM, Harris MA. 2012. Duodenal GSH/GSSG ratios in mice following oral exposure to Cr(VI). Toxicol Sci 126(1):287-288.

Kirman CR, Hays SM, Aylward LL, Suh M, Proctor D. 2012. Physiologically-based pharmacokinetic model for mice, rats and humans orally-exposed to chromium. Presented at the Society of Toxicology’s 51st Annual Meeting, March 11-15, San Francisco, CA.

Kopec A, Forgacs AL, Kim S, Thompson CM, Zacharewski T. 2012. Comparative toxicogenomic analysis of Cr(VI) effects in rat and mouse small intestine. Presented at the Society of Toxicology’s 51st Annual Meeting, March 11-15, San Francisco, CA.

Berman DW, Brorby GP, Sheehan PJ, Bogen KT, Holm SE. 2012. More on the dynamics of dust generation: The effects of mixing and sanding chrysotile, calcium carbonate, and other compounds on the characteristics of joint-compound dusts. Ann Occup Hyg 56(7):852-867.

Mounho B. 2012. Overview of the history and development of regional guidelines for the approval of biosimilar products. Presented at the Society of Toxicology’s 51st Annual Meeting, March 11-15, San Francisco, CA.

Fowler, JC, Bhattacharya S, Urban JD, Vaidehi N, Mailman RB. 2012. Receptor conformations involved in dopamine D2L receptor functional selectivity induced by selected transmembrane 5 serine mutations. Mol Pharmacol 81(6):820-831.

O’Brien TJ, Hao D, Suh M, Proctor D, Thompson CM, Harris MA, Parsons BL, Meyers MB. 2012. K-ras codon 12 GGT to GAT mutation is not elevated in the duodenum of mice subchronically exposed to hexavalent chromium in drinking water. Presented at the Society of Toxicology’s 51st Annual Meeting, March 11-15, San Francisco, CA.

Henderson RG, Durando J, Oller A, Merkel DJ, Marone PA,  Bates HK. 2012. Acute oral toxicity of nickel compounds. Regul Toxicol Pharmacol 62(3):425-432.

Henderson RG, Cappellini D, Seilkop SK, Bates HK, Oller AR. 2012. Oral bioaccessibility testing and read-across hazard assessment of nickel compounds. Regul Toxicol Pharmacol 63(1):20-28.

Perry C, Tachovsky JA, Ke M, Urban J, Haws L. 2012. Natural gas exploration and production in the Barnett Shale: Assessment of exposures to volatile organic compounds (VOCs). Presented at the Society of Toxicology’s 51st Annual Meeting, March 11-15, San Francisco, CA.

Urban J, Budinsky R, Rowlands J. 2012. An evaluation of single nucleotide polymorphisms in the human heat shock protein 90kDa alpha and beta isoforms. Drug Metab Pharmacokinet 27(2):268-278.

Proctor DM, Thompson CM, Suh M, Haws LC, Harris MA. 2012. Mode of action for intestinal carcinogenesis of ingested hexavalent chromium in mice. Presented at the Society of Toxicology’s 51st Annual Meeting, March 11-15, San Francisco, CA.

Thompson CM, Hixon JG, Kopec AK, Harris MA, Proctor DM, Haws LC. 2012. Assessment of genotoxic potential of Cr(VI) in the mouse duodenum via toxicogenomic profiling. Presented at the Society of Toxicology’s 51st Annual Meeting, March 11-15, San Francisco, CA.

Urban J, Rowlands JC, Budinsky R, Dombkowski A, Thompson CM, Thomas RS. 2012. A genomics-based benchmark dose analyses of relative potencies of dioxin-like compounds in primary rat hepatocytes. Presented at the Society of Toxicology’s 51st Annual Meeting, March 11-15, San Francisco, CA.

Wikoff D, DeVito M, Walker N, Hixon G, Harris M, Tachovsky A, Birnbaum L, Haws L. 2012. Application of machine learning in the development of a weighting framework for evaluating eEstimates of relative potency for dioxin-like compounds. Presented at the Society of Toxicology’s 51st Annual Meeting, March 11-15, San Francisco, CA.

Mounho B. 2012. Regulatory standards for the approval of biosimilar products: A global review. Presented in Münster, Germany, May 23.

Mounho B. 2012. History and review of regulatory pathways for the approval of biosimilar products. Presented at Applied Pharmaceutical Toxicology Annual Meeting, May 17, Baltimore, MD.

Thompson C, Perry C, Gaylor D, Tachovsky A, Burkhalter B, Haws L. 2011. Derivation of an oral reference dose and drinking water screening level for sulfolane using benchmark dose modeling. Presented at the Society of Toxicology’s 50th Annual Meeting, March 6-10, Washington, D.C.

Thompson CM, Proctor DM, Haws LC, Hebert CD, Grimes SD, Shertzer HG, Kopec AK, Hixon JG,  Zacharewski TR, Harris MA. 2011. Investigation of the mode of action underlying the tumorigenic response induced in B6C3F1 mice exposed orally to hexavalent chromium. Toxicol Sci 123(1): 58-70.

Mounho B. 2011. Definitions and standards for the approval of biosimilar products. Presented at American College of Toxicology Annual Meeting, November, Phoenix, AZ.

Bogen KT, Brorby GP, Berman DW, Sheehan PJ, Floyd M.  2011. Measuring mixed cellulose ester (MCE) filter mass under variable humidity conditions.  Ann Occup Hyg 55(5)485-494.

Urban J, Fitzgerald L, Burkhalter B, Staskal D, Harris M, Haws L. 2011. BTEX serum levels in the general U.S. population: An analysis of 2003-2004 NHANES dataset. Presented at the Society of Toxicology’s 50th Annual Meeting, March 6-10, Washington, D.C.

Thompson CM, Haws LC, Harris MA, Gatto NM, Proctor DM. 2011. Application of the U.S. EPA mode of action framework for purposes of guiding future research: A case study involving the oral carcinogenicity of hexavalent chromium. Toxicol Sci 119(1):20-40.

Diliberto JJ, Sirinek L, Burkhalter B, Wikoff DS, Hixon G, Becker J, Patterson DG, Turner W, Tachovsky JA, Birnbaum LS, Haws LC. 2011. Endometriosis in a cohort of women living in the Kanawha River Valley in West Virginia: Blood levels of non-dioxin-like PCBs and relationship with BMI and age. Presented at Dioxin 2011, August 21-25, Brussels, Belgium.

Bussiere J, Leach M, Price K, Mounho B, Lightfoot-Dunn R. 2011. Survey results on the use of the tissue cross-reactivity immunohistochemistry assay. Reg Toxicol Pharm 59(3):493-505.

Oller A, Henderson RG. 2011. Bioaccessibility testing and its application to read-across for hazard assessment and risk characterisation of metals. Annual meeting of the Belgian Society for Toxicology and Ecotoxicology (BelTox).

Haws LC, DeVito MJ, Walker NJ, Harris MA, Tachovsky JA, Birnbaum LS, Farland WH, Wikoff DS. 2011. Development of a consensus-based weighting framework for evaluating estimates of relative potency for dioxin-like compounds that includes consideration of data from human cells. Presented at Dioxin 2011, August 21-25, Brussels, Belgium.

Brorby GP, Sheehan PJ, Berman DW, Bogen KT, Holm SE. 2011. Potential artifacts associated with historical preparation of joint compound samples and reported airborne asbestos concentrations.  J Occup Environ Hyg 8(5):271–278.

Semeraro A, Patriarca M, Taylor A, Henderson R, Bates H. 2011. Nickel kinetics after oral exposure: Urinary excretion. IUPAC 4th International Symposium for Trace Elements in Food.

Haws LC, Fitzgerald L, Burkhalter B, Harris M, Wikoff DS. 2011. Assessment of the US EPA’s proposed toxicological values for TCDD for regulation of dioxin-like compounds in foods: Bridging the science divide in a global market. Presented at Dioxin 2011, August 21-25, Brussels, Belgium.

Rowlands JC, Urban J, Wikoff DS, Budinsky R. 2011. The presence and estimated functional effect of single nucleotide polymorphisms at the AIP, ARNT, HSP90AA1, AND HSP90AB1 loci in the human population. Presented at Dioxin 2011, August 21-25, Brussels, Belgium.

Gujral JS, Proctor DM, Su SH, and Fedoruk JM. 2011. Water adherence factors for human skin. Risk Analysis 31(8):1271-1280.

Thomas RS, Rowlands JC, Budinsky RA, Thompson CM, Urban JD. Dombkowski, A. 2011. Genomic approaches for relative potency assessment. Presented at Dioxin 2011, August 21-25, Brussels, Belgium.

Miletich J, Eich G, Grampp G, and Mounho B. 2011. Guiding principles for a global “patients first” standard. mAbs 3(3):318-325.

Wikoff DS, Thompson C, Walker N, DeVito M, Harris M, Birnbaum L, Haws L. 2011. Derivation of relative potency estimates using benchmark dose modeling: A case study with TCDF. Presented at Dioxin 2011, August 21-25, Brussels, Belgium.

Rowlands JC, Urban JD, Wikoff DS, Budinsky RA. 2011. An evaluation of single nucleotide polymorphisms in the human aryl hydrocarbon receptor-interacting protein (AIP) gene. Drug Metab Pharmacokinet 26(4):431-439.

Budinsky R, Urban J, Rowlands JC. 2011. An evaluation of single nucleotide polymorphisms in the human aryl hydrocarbon receptor nuclear translocator gene. Presented at the Society of Toxicology’s 50th Annual Meeting, March 6-10, Washington, D.C.

Sheehan PJ, Brorby GP, Berman DW, Bogen KT, Holm SE. 2011. Chamber for testing asbestos-containing products:  Validation and testing of a re-created chrysotile-containing joint compound.  Ann Occup Hyg 55(7):797-809.

Ceder R, Merne M, Nilsson J-A, Staab C, Höög J-O, Thompson CM, Grafström RC. 2011.  Toxicogenomic profiling of formaldehyde-exposed normal and transformed human oral keratinocytes. Presented at the Society of Toxicology’s 50th Annual Meeting, March 6-10, Washington, D.C.

Fitzgerald L, Burkhalter B, Urban J, Staskal D, Harris M, Haws L. 2011. VOC serum levels in the general U.S. population: An analysis of the 2003-2004 NHANES dataset. Presented at the Society of Toxicology’s 50th Annual Meeting, March 6-10, Washington, D.C.

Haws L, Proctor D, Thompson C, Harris M. 2011. Research plan to fill data gaps in the mode of action for cancer risk assessment of hexavalent chromium in drinking water. Presented at the Society of Toxicology’s 50th Annual Meeting, March 6-10, Washington, D.C.

Tichomirowa MA, Bariler A, Daly AF, Jaffrain-Rea M-L, Ronchi CL, Yaneva M, Urban JD, Petrossians P, Elenkova AP, Tabarin A, Desailloud R, Maiter D, Schürrmeyer T, Cozzi R, Theodoropoulou M, Sievers C, Bernabeu I, Naves LA, Chabre O, Fajardo Montañana C, Hana V, Halaby G, Delemer B, Labarta JI, Sonnet E, Ferrandez A, Hagelstein MTS, Caron P, Stalla GK, Bours V, Zacharieva S, Spada A, Brue T, Beckers A. 2011. High prevalence of AIP gene mutations following focused screening in young patients with sporadic pituitary macroadenomas. Eur J Endocrinol 165(4):509-515.

Henderson RG, Cappellini D, Seilkop S, Oller A, Bates H. 2011. Bioaccessibility-based read-across assessment of nickel compounds for oral systemic toxicity. Presented at the Society of Toxicology’s 50th Annual Meeting, March 6-10, Washington, D.C.

Urban JD, Rowlands JC, Budinsky RA. 2011. Single nucleotide polymorphisms in the human aryl hydrocarbon receptor nuclear translocator (ARNT) gene. Drug Metab Pharmacokinet 26(6):637-645.

Kim S, Thompson CM, Kopec AK, Harris MA, Zacharewski TR. 2011. Comparison of basal and CrVI-mediated solute carrier gene expression in rodent duodenal epithelium. Presented at the Society of Toxicology’s 50th Annual Meeting, March 6-10, Washington, D.C.

Wilson VS, Keshava N, Hester S, Segal D, Chiu W, Thompson CM, Euling SY. 2013. Utilizing toxicogenomic data to understand chemical mechanism of action in risk assessment. Toxicol Appl Pharmacol 271:299–308.

Proctor D, Haws L,Thompson C, Harris M. 2011. Use of mode of action and pharmacokinetics to inform the cancer risk assessment of ingested Cr(VI): A case study. Presented at the Society of Toxicology’s 50th Annual Meeting, March 6-10, 2011. Washington, D.C.

Buckley L, Chapman K, Burns Naas LA, Todd M, Martin P, Lansita J. 2011. Considerations regarding nonhuman primate use in safety assessment of biopharmaceuticals. Int J Toxicol 30(5):583-590.

Proctor D, Meek B. 2011. Using mode of action data to guide quantitative cancer risk assessment: A case study of hexavalent chromium in drinking water. Presented at the Society of Toxicology’s 50th Annual Meeting, March 6-10, Washington, D.C.

Staskal-Wikoff D, Budinsky R, Rowlands JC. 2011. Single nucleotide polymorphisms in the human aryl hydrocarbon receptor interacting protein (AIP) gene from six ethnic populations. Presented at the Society of Toxicology’s 50th Annual Meeting, March 6-10, Washington, D.C.

Johns DO, Owens EO, Thompson CM, Sonawane B, Hattis D, Krishnan K. 2010. Physiological parameters and databases for PBPK modeling. Chapter 5 in: Quantitative Modeling in Toxicology. Krishnan K, Andersen M (eds.). Wiley, p. 107.

Harris M, Tachovsky JA, Staskal-Wikoff D, Aylward L, Burkhalter B, Simon T, Haws L. 2010. Serum concentrations of dioxin-like compounds in a population in Midland, Michigan: An evaluation of the impact of soil exposures. Presented at Dioxin 2010, September 12-17, San Antonio, TX.

Harris M, Tachovsky JA, Staskal-Wikoff D, Simon T, Burkhalter B, Urban J, Haws L. 2010. Assessment of the impact of various soil cleanup levels on serum concentrations of dioxin-like compounds in humans. Presented at the 49th Annual Meeting of Society of Toxicology. March 7-11, Salt Lake City, Utah.

Birnbaum LS, Staskal-Wikoff D. 2010. 5th International PCB Workshop–Summary and implications. Environ Int 36(8):814-818.

Haws L. 2010. Biomonitoring – A tool for assessing community exposures to air toxics. Presented at the Air Quality 2010 conference, hosted by the University of Texas School of Law,  November 19.

Gatto NM, Kelsh MA, Mai DH, Suh M, Proctor DM. 2010. Occupational exposure to hexavalent chromium and cancers of the gastrointestinal tract: A meta-analysis. Cancer Epidemiol 34(4):388-99.

Haws L, Tachovsky JA, Staskal-Wikoff D, Aylward L, Burkhalter B, Urban J, Simon T, Harris M. 2010. An evaluation of the influence of different soil cleanup levels on the concentration of dioxin-like compounds in human serum. Presented at Dioxin 2010, September 12-17, San Antonio, TX.

Mounho B, Phillips A, Holcombe K, Grampp G, Lubiniecki T, Mollup I, Jones C. 2010. Global regulatory standards for the approval of biosimilars. Food Drug Law J 65(4):819-837.

Haws L. 2010. Biomonitoring: The circle of life. Presented in the Oil and Gas special session, at the 22nd Annual Texas Environmental Superconference, August 5-6, Austin, TX.

Rowlands CJ, Staskal DF, GollapudI B, Budinsky R. 2010. The Human AHR: Identification of single nucleotide polymorphisms from six ethnic populations. Pharmacogenet Genomics 20(5):283-290.

Staskal-Wikoff D, Burkhalter B, Stapleton H, Harris M. 2010. PBDEs in Newark Bay sediments. Presented at Dioxin 2010, September 12-17, San Antonio, TX.

Sheehan P, Bogen KT, Hicks J, Goswami E, Brorby G, Lau E, Ott B.  2010. Benzene inhalation of parts washers:  New estimates based on measures of occupational exposure to solvent coaromatics.  Risk Analysis 30(8):1249–1267.

Tachovsky JA, Haws L. 2010. Application of principal components analysis and sequential gaussian simulation to a comprehensive soil sampling dataset to predict PCDD/F concentrations in Midland, MI. Presented at Dioxin 2010, September 12-17, San Antonio, TX.

Tachovsky JA, Urban JD, Wikoff DS, Haws LC, Harris MA. 2010. Reduction of a large fish tissue analyte database: identifying and assessing data specific to a remediation site for risk assessment application. Chemosphere 80(5):481-488.

Mounho B. 2010. Safety evaluation of biotechnology derived products. Presented at Toxicology for Industrial and Regulatory Scientists, Sponsored by American College of Toxicology. April, Falls Church, VA.

Thompson CM, Grafström RC. 2010. Considerations for the implausibility of leukemia induction by formaldehyde. Toxicol Sci 120(1):230-232.

Waters MD, Jackson MA, Lea IA. 2010. Characterizing and predicting carcinogenicity and mode-of-action using conventional and toxicogenomics methods. Mutat Res 705(3):184–200.

Mounho, B. 2010. General review of the types of anti-drug antibody-mediated responses that can occur in toxicology studies. Presented at the 49th Annual Meeting of Society of Toxicology, March 7-11, Salt Lake City, Utah.

Tachovsky A, Staskal D, Urban J, Harris MA, Haws L. 2010. Assessment of environmental data collected in a community with numerous petroleum refining and petrochemical facilities. Presented at the 49th Annual Meeting of Society of Toxicology. March 7-11, Salt Lake City, Utah.

Thompson CM, Ceder R, Grafström RC. 2010. Formaldehyde dehydrogenase: Beyond phase I metabolism. Toxicol Lett 193(1):1-3.

Tachovsky JA, Haws L. 2010. Geostatistical estimation of soil PCDD/F TEQ using sequential Gaussian simulation and the aggregation of results in Midland, MI. Presented at the Society for Risk Analysis annual meeting, December 5-8, Salt Lake City, UT.

Urban JD, Tachovsky JA, Haws LC, Wikoff Staskal D, Harris MA. 2010. Response to Mugdan et al.’s comment on Urban et al. “Assessment of Human Health Risks Posed by Consumption of Fish from the Lower Passaic River, New Jersey.” Sci Tot Environ 408(6):1468-1470.

Urban J, Burkhalter B, Tachovsky JA, Haws L, Harris M. 2010. Evaluation of polychlorinated naphthalenes (PCNs) in Newark Bay sediment. Presented at Dioxin 2010, September 12-17, San Antonio, TX.

Urban JD, Tachovsky JA, Haws LC, Staskal DF, and Harris MA. 2010. Response to Buchanan et al.’s comment on Urban et al. “Assessment of Human Health Risks Posed by Consumption of Fish from the Lower Passaic River, New Jersey.” Sci Tot Environ 408(8):2004-2007.

Driscoll SK, McArdle ME, Plumlee MH and Proctor D. 2010. Evaluation of hexavalent chromium in sediment pore water of the Hackensack River, New Jersey, USA. Environ Toxicol Chem 29(3):617-20.

Haws LC, DeVito MJ, Walker NJ, Birnbaum LS, Farland WH, Harris MA, Tachovsky JA, Unice KM, Scott PK, Staskal-Wikoff DF. 2009. Development of distributions of relative potency estimates to quantitatively assess uncertainty inherent in the TEFs for dioxin-like compounds: A proposed consensus-based weighting. Presented at Dioxin 2009, Beijing, China.

Guzelian PS, Victoroff MS, Halmes C,  James RC. 2009. Clear path: Towards an evidence-based toxicology (EBT). Human & Exp Toxicol 28:71-79.

Staskal-Wikoff DF, Harris MA, Haws LC, Birnbaum LS, Tachovsky JA. 2009. Probabilistic evaluation of cancer and non-cancer risk associated with exposure to BDE 209 in automobiles. Presented at Dioxin 2009. Beijing, China.

Oller AR, Cappellini D, Henderson RG, Bates HK. 2009. Temperature effect on nickel release in ammonium citrate.  J Environ Monit 11(9):1697-1699.

Urban JD, Tachovsky JA, Staskal DF, Haws LC, Harris MA. 2009. Human health risk assessment of consumption of fish from the Lower Passaic River. Presented at the 48th Annual Meeting of Society for Toxicology, March 15-19, Baltimore, MD.

Oller AR, Cappellini D, Henderson RG, Bates HK. 2009. Comparison of nickel release in solutions used for the identification of water-soluble nickel exposures and in synthetic lung fluids. J Environ Monit 11(4):823–829.

Mounho B. 2009. Small molecule and biological therapeutics: History and inherent differences. Presented at Cambridge Healthtech Institute’s PEGS Summit, April 6-10, Boston, MA.

Menzie CA, Ziccardi LM, Lowney YW, Fairbrother A, Shock SS, Tsuji JS, Hamai D, Proctor D, et al. 2009. Importance of considering the framework principles in risk assessment for metals. Environ Sci Technol 43(22):8478-8482.

Mounho B. 2009. Preclinical toxicology studies to support the development of monoclonal abs: Scientific issues and challenges. Presented at Cambridge Healthtech Institute’s PEGS Summit, April 6-10, Boston, MA.

Scott, LLF, Staskal, DF, Williams ES, Luksemburg WJ, Urban JD, Nguyen LM, Haws LC, Birnbaum LS, Paustenbach DJ, Harris MA. 2009. Levels of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls in southern Mississippi catfish and estimation of potential health risks. Chemosphere 74(7):1002-10.

Mounho B. 2009. Scientific challenges in preclinical studies to support the clinical development of biologics. Presented at Cambridge Healthtech Institute’s Molecular Medicine Tri-Conference, February 25-27, San Francisco, CA.

Thompson CM, Grafstrom RC. 2009. Commentary: Mechanistic considerations for associations between formaldehyde exposure and nasopharyngeal carcinoma. Environ Health 8:53.

Mounho B. 2009. Preclinical development of biologics. Presented at Cambridge Healthtech Institute’s Molecular Medicine Tri-Conference, February 25-27, San Francisco, CA.

Thompson CM, Sonawane B, Grafström RC. 2009. The ontogeny, distribution and regulation of alcohol dehydrogenase 3: Implications for pulmonary physiology. Drug Metab Disposit 37(8):1565-1571.

Mounho B. 2009. Comparability challenges: Regulatory and scientific issues in the assessment of biopharmaceuticals. Presented at Drug Information Association Meeting.

Thompson CM, Johns DO, Sonawane S, Barton HA, Hattis D, Tardif R, Krishnan K. 2009. Database for physiologically based pharmacokinetic (PBPK) modeling: Physiological parameters for healthy and health-impaired elderly. J Toxicol Environ Health, Part B 12:1–24.

Lea IA, Jackson MA, Dunnick JK. 2009. Genetic pathways to colorectal cancer. Mutat Res 670(1–2):96–98.

Mounho B. 2009. Nonclinical safety assessment studies to support manufacturing process changes for Vectibix®. Presented at Drug Information Association Meeting.

Urban, JD, Tachovsky JA, Staskal DF, Haws LC, Harris MA. 2009. Assessment of human health risks posed by consumption of fish from the Lower Passaic River, New Jersey. Sci Total Environ 408(2):209-224.

Proctor, D. 2008. Hexavalent chromium. In: Encyclopedia of Quantiative Risk Analysis and Assessment, Melnick E, Everitt B. (eds.). Wiley.

Harris MA, Tachovsky JA, Williams ES, Paustenbach DP, Haws LC. 2008. Assessment of the health risks posed by benzene in soft drinks. Presented at the Society of Toxicology Annual Meeting, March 16-20, Seattle, WA.

DeWoskin RS, Thompson CM. 2008. Renal clearance parameters for PBPK model analysis of early lifestage differences in the disposition of environmental toxicants. Regul Toxicol Pharmacol 51:66–86.

Haws LC, Unice KM, Tachovsky AT, Harris MA, DeVito MJ, WalkerNJ, Birnbaum LS, Farland WH, Nguyen L, Staskal DF. 2008. Assessment of the impact of using weighted distributions of REPs to develop exposure estimates for dioxin-like compounds. Presented at Dioxin 2008, August 17-22, Birmingham, England.

Donovan E, Unice K, Roberts JD, Harris M, Finley B. 2008. Risk of gastrointestinal disease associated with exposure to pathogens in the water of the Lower Passaic River. Appl Environ Microbiol 74:994-1003.

Haws LC, DeVito MJ, Walker NJ, Birnbaum LS, Unice KM, Scott PK, Harris MA, Tachovsky A, Farland WH, Finley BF,  Staskal DF. 2008. Development of weighted distributions of REPs for dioxin-like compounds: Implications for risk assessment. Presented at the Society of Toxicology Annual Meeting, March 16-20, Seattle, WA.

Donovan EP, Staskal DF, Unice KM, Roberts JD, Haws LC, Finley BL, and Harris MA. 2008. Risk of gastrointestinal disease associated with exposure to pathogens in the sediments of the Lower Passaic River. Appl Environ Microbiol 74:1004-1018.

Scott LLF, Staskal DF, Harris MA, Finley BL, Haws LC. 2008. Evaluation of dioxin-like compounds in workers from a primary magnesium production facility relative to levels observed in the general US population. Presented at the Society of Toxicology Annual Meeting, March 16-20, Seattle, WA.

Haws LC, Tachovsky JA, Williams ES, Scott LF, Paustenbach D, Harris MA. 2008. Assessment of potential human health risks posed by benzene in beverages. J Food Sci 73(4):T33-T41.

Staskal DF, Donovan EP, Haws LC, Roberts JD, Unice KM, Finley BL, Harris MA. 2008. Human health risks associated with exposure to pathogens in waters and sediments of the Lower Passaic River. Presented at the Society of Toxicology Annual Meeting. March 16-20, Seattle, WA.

James HR, Barfield L, Britt JK, James RC. 2008. Worker exposure to secondhand smoke: Evaluating a prediction model. Prof Saf Sep:34-44.

Staskal DF. 2008. Roundtable: Case study on the risks and benefits of DecaBDE, a major brominated flame retardant. Presented at the Society of Toxicology Annual Meeting, March 16-20, Seattle, WA.

Makris SL, Thompson CM, Euling SY, Selevan SG, Sonawane B. 2008. A lifestage-specific spproach to hazard and dose-response characterization for children’s health risk assessment. Birth Defects Res Part B 83:530–546.

Staskal DF, Tachovsky JA, Harris MA, Haws LC. 2008. Preliminary evaluation of human health risk associated with exposure to PBDEs in the United States. Presented at Dioxin 2008, August 17-22, Birmingham, England.

Richardson VM, Staskal DF, Ross DG, Diliberto JJ, Devito MJ, Birnbaum LS. 2008. Possible mechanisms of thyroid hormone disruption in mice by BDE 47, a major polybrominated diphenyl ether congener. Toxicol Appl Pharmacol 226(3):244-250.

Tachovsky JA, Harris MA, Staskal DF, Scott LF, Luksemburg WJ, Paustenbach DP, Haws LC. 2008. Analysis of fish tissue concentrations of dioxins and furans using principal components analysis. Presented at Dioxin 2008, August 17-22, Birmingham, England.

Scott LLF, Harris MA, Unice KM, Scott P, Nguyen LM, Haws LC, and Paustenbach D. 2008. Addendum to: Evaluation of PCDD/F and dioxin-like PCB serum concentration data from the 2001-2002 National Health and Nutrition Examination Survey of the United States population. J Exp Sci Env Epidemiol 18(5):524-532.

Tachovsky JA, Staskal DF, Harris MA, Scott LF, Luksemburg WJ, Paustenbach DP, Haws LC. 2008. Principal components analysis of PBDE concentrations in fish tissue from southern Mississippi. Presented at Dioxin 2008, August 17-22, Birmingham, England.

Scott PK, Proctor D. 2008. Soil suspension/dispersion modeling methods for estimating health-based soil cleanup levels of hexavalent chromium at chromite ore processing residue sites. J Air Waste Manag Assoc 58(3): 384-403.

Urban JD, Haws LC, Staskal DF, Scott LF, Scott PS, Tachovsky AT, Unice KM, Harris MA. A framework for evaluating serum dioxin data derived from biomonitoring studies. Presented at Dioxin 2008, August 17-22, 2008. Birmingham, England.

Staskal DF, Scott LLF, Haws LC, Luksemburg WJ, Birnbaum LS, Nguyen LM, Urban JD, Williams ES, Paustenbach DJ, Harris MA. 2008. Assessment of polybrominated diphenyl ether exposures and health risks associated with consumption of southern Mississippi catfish. Environ Sci Technol 42(17):6755-6761.

Urban JD, Haws LC, Scott LF, Scott PS, Staskal DF, Tachovsky AT, Unice KM, Harris MA. 2008.A framework for evaluating serum dioxin data derived from biomonitoring studies. Presented at the Society of Toxicology Annual Meeting. March 16-20, Seattle, WA.

Subramaniam RP, Chen C, Crump KS, Devoney D, Fox JF, Portier CJ, Schlosser PM, Thompson CM, White P. 2008. Uncertainties in biologically-based modeling of formaldehyde-induced respiratory cancer risk: Identification of key issues. Risk Analysis 28(4):907–923.

Thompson CM, Subramaniam RP, Grafström RC. 2008. Mechanistic and dose considerations for supporting adverse pulmonary physiology in response to formaldehyde. Toxicol Appl Pharmacol 233(3):355–359.

Williams CW, Perry CS. 2008. Risk assessment for arsenic on indoor surfaces. Presented at the Society for Risk Analysis annual meeting, December 7-10, Boston, MA.

Thompson CM, Sonawane B, Barton HA, DeWoskin RS, Schlosser P, Lipscomb JC, Chiu W, Krishnan K. 2008. Approaches for applications of physiologically based pharmacokinetic models in risk assessment. J Toxicol Environ Health, Part B 11(7):519–547.

DeSesso JM, Watson RE, Keen CL, Hazelden KP, Haws LC, Li AA. 2008. Analysis and integration of developmental neurotoxicity and ancillary data into risk assessment: A case study of dimethoate. J Toxicol Environ Health A 72(2):94-109.

Britt, J.K. and R.C. James. Toxicology. In: Kirk-Othmer Encyclopedia of Chemical Technology. John Wiley & Sons, Inc., Hoboken, NJ. pp. 201-252,  2007.

Ferriby LL, Knutsen JS, Harris MA, Unice KM, Scott P, Nony P, Haws LC, and Paustenbach D. 2007. Evaluation of PCDD/F and dioxin-like PCB serum concentration data from the 2001-2002 National Health and Nutrition Examination Survey of the United States Population. J Exp Sci Environ Epidemiol 17:358-371.

Staskal, D.F., and L.S. Birnbaum. 2007. Brominated Flame Retardants, Maxcy-Rosenau Public Health and Preventive Medicine, 15th Edition.

DeSesso, J., R.E. Watson, C.L. Keen, K.P. Hazleden, L.C. Haws, and A.A. Li. 2007. Integration of Developmental Toxicity Data into Risk Assessment: A Case Study of Dimethoate. Society of Toxicology. March 25-29, 2007. Charlotte, NC.

Proctor DM, Gatto NM, Hong SJ, Allamneni KP. 2007. Mode-of-action framework for evaluating the relevance of rodent forestomach tumors in cancer risk assessment. Toxicol Sci. 98(2):313–326.

Diliberto, J.J., D.F. Staskal, H. Hakk, and L.S. Birnbaum. 2007. Differential Urinary Protien binding of PBDEs in Mice. Society of Toxicology. March 25-29, 2007. Charlotte, NC.

Dwyer, M., Perry, C., and Jenkins, A. Trichloroethylene toxicity and risks: recent developments and potential implications. Presented at February 2007 Texas Association of Environmental Professionals — Environmental Challenges and Innovations Conference.

Emond, C., J. Raymer, E. Garner, J. Diliberto, D. Staskal, and L.S. Birnbaum. 2007. A physiologically-based pharmacokinetic model for developmental exposure to PBDE-47 in rodents. Society of Toxicology. March 25-29, 2007. Charlotte, NC.

Simon T, Britt JK and James RC. 2007. Development of a neurotoxic equivalence scheme of relative potency for assessing the risk of PCB mixtures. Regul. Toxicol. Pharmacol. 48:148-170.

Ferriby, L.L., M.A. Harris, K.M. Unice, P.K. Scott, L.C. Haws, D.J. Paustenbach. 2007. Development of PCDD/F and dioxin-like PCB serum concentration reference values for the general U.S. population using the 2006 WHO TEFs and the 2001-2002 NHANES data.Society of Toxicology. March 25-29, 2007. Charlotte, NC.

Thompson CM and Grafström RC. 2007. Mechanistic Considerations for Formaldehyde- Induced Bronchoconstriction Involving S-Nitrosoglutathione Reductase. Journal of Toxicology and Environmental Health, Part A. 71, 244–248.

Harris, M., L.L.F. Scott, L.M. Nguyen, and L.C. Haws. Trends in Elevated Blood Lead Levels of U.S. Children and Associated Demographic Characteristics. Ann Epidemiol. 17:748.

Urban JD, Clarke WP, von Zastrow M, Kobilka B, Nichols DE, Weinstein H, Javitch JA, Roth BL, Christopoulos A, Sexton PM, Miller KJ, Spedding M, and Mailman RB. 2007. Functional selectivity and classical concepts of quantitative pharmacology. J. Pharmacol Exp Therap. 320 (1): 1-13.

Harris, M., J.A.Tachovsky, E.S. Williams, L.L.F Scott, L. Nguyen, L.C. Haws. 2007. Risks Posed by Air Pollutants in the Houston Metropolitan Area. Society for Risk Analysis Annual Meeting. December 9-12, 2007. San Antonio, TX.

Urban JD, Vargas G, von Zastrow M, and Mailman RB. 2007. Aripiprazole has functionally selective actions at D2 receptor-mediated signaling pathways. Neuropsychopharmacology. 32 (1): 67-77.

Harris, M., L.C. Haws, A. Tachosvky, E.S. Williams, L.M. Nguyen, L.F. Scott. Interactive Processes in Toxicity Assessments. Air Toxics Research: Implications of Research on Policies to Protect Public Health. June 12-13, 2007. Houston, TX.

Haws, L.C., L.L.F. Scott, D.F. Staskal, M.A. Harris, and B.L. Finley. 2007. Dioxin-like Compounds in Workers at a Primary Magnesium Production Facility. Dioxin 2007, September 2-7, 2007. Tokyo, Japan.

Haws, L.C., L.L.F. Scott, D.F. Staskal, M. Harris, and B. Finley. 2007. Evaluation of Biomonitoring Data for Dioxin-like Compounds in Workers at a Primary Magnesium Production Facility. Society for Risk Analysis Annual Meeting. December 9-12, 2007. San Antonio, TX.

Haws LC, Walker NJ, DeVito MJ, Birnbaum LS, Unice KM, Scott PK, Harris MA, Farland WH, Finley BL, Staskal DF. 2007. Development of weighted distributions of REPs for dioxin-like compounds (DLCs). Society of Toxicology Annual Meeting. March 25-29, Charlotte, NC.

Mounho, B. Comparison of Nonclinical Toxicology Programs for Epidermal Growth Factor Antagonists for Cancer Therapy: Monoclonal Antibodies Vectibix® and Erbitux® vs. Small Molecules Iressa® and Tarceva®. Presented at BioSafe General Membership Annual Meeting. 2007.

Mounho, B. Therapeutic Biologics. Presenter and course director: Biologics Drug Development: An Integrated Overview of Manufacturing, Nonclinical, Clinical, and Regulatory Requirements, PERI Course. Bethesda, MD. 2007.

Mounho, B. Nonclinical Safety Assessment of Therapeutic Biologics. Presenter and course director: Biologics Drug Development: An Integrated Overview of Manufacturing, Nonclinical, Clinical, and Regulatory Requirements, PERI Course. Bethesda, MD. 2007.

Nguyen, L.M., L.L.F. Scott, M. Harris, and L.C. Haws. Factors Contributing to Blood Lead Levels in U.S. Children Based on NHANES Data. 2007 Ann Epidemiol. 17:734-735.

Perry, C.S. Vibrios in surface waters and a hypothetical scenario using EPA’s Environmental Consequence Assessment Tool (ECAT). Society for Risk Analysis annual meeting, December 9-12, 2007. San Antonio, TX.

Scott, L.L.F., M. Harris, K.M. Unice, P. Scott, L.M. Nguyen, L.C. Haws, and D. Paustenbach. 2007. Effects of Excluding Serum PCDD/F and Dioxin-like PCB data of Individuals with Incomplete congener Profiles on Estimates of Total TEQ. Ann Epidemiol. 17:732.

Scott, P., L.C. Haws, L. Scott, and M. Harris. 2007. Evaluation of Background 2,3,7,8-PCDD/F Congener Profiles in Human Serum Collected During NHANES 2001-2002 Using Principal Components Analysis. Dioxin 2007, September 2-7, 2007. Tokyo, Japan.

Scott, P., L.C. Haws, L. Scott, and M. Harris. 2007. Evaluation of Background Dioxin-like PCB Congener Profiles in Human Serum Collected During NHANES 2001-2002 Using Principal Components Analysis. Dioxin 2007, September 2-7, 2007. Tokyo, Japan.

Smith, J.D., Perry C., Garcia, S., Jenkins, A., Dwyer, M., Garrahan, K. Emergency Consequence Assessment Tool (ECAT) for USEPA NHSRC. Society for Risk Analysis annual meeting, December 9-12, 2007. San Antonio, TX.

Staskal, D.F., E.P. Donovan, L.C. Haws, J.D. Roberts, K.M. Unice, B.L. Finley, and M.A. Harris. A Quantitative Microbial Risk Assessment for Exposure to Pathogens in Waters and Sediments of the Lower Passaic River. Society for Risk Analysis annual meeting, December 9-12, 2007. San Antonio, TX.

Staskal, D.F., L.L.F. Scott, E.S. Williams, W.J. Luksemburg, L.C. Haws, L.S. Birnbaum, L.M. Nguyen, D.J. Paustenbach, and M.A. Harris. Daily intake estimates of PBDEs associated with consumption of catfish in the U.S. Presented at the Fourth International Workshop on Brominated Flame Retardants. April 24-27, 2007. Amsterdam, the Netherlands.

Staskal, D.F., E. Donovan, J. Roberts, K. Unice, B. Finley, and M. Harris. 2007. Human Health Risk Associated with Exposure to Pathogen-Contaminated Sediments. Society of Toxicology. March 25-29, 2007. Charlotte, NC.

Tachovsky, J.A., L.C. Haws, L.F Scott, E.S. Williams, and M. Harris. Benzene in Soft Drinks and Other Beverages: Do Measured Levels Pose a Human Health Risk? Society for Risk Analysis’ Annual Meeting. December 9-12, 2007. San Antonio, TX.

Urban, J.D., K. Thornley, R.W. Wightman, and R.B. Mailman. 2007. Pharmacological characterization of the N27-D2L cell line: assessment as a viable cell model for investigating D2L receptor dopaminergic-coupled functions. Society of Toxicology. March 25-29, 2007. Charlotte, NC.

Williams, E.S., L.L. Ferriby, L.C. Haws, D.J. Paustenbach, and M.A. Harris. 2007. Assessment of potential human health risks posed by benzene in a commercial beverage. Society of Toxicology. March 25-29, 2007. Charlotte, NC.

Ferriby, L.L., E.S. Williams, W.J. Lukesemburg, D.J. Paustenbach, L.C. Haws, L.S. Birnbaum, and M. Harris. 2006. Comparing Polychlorinated Biphenyls in Farm-Raised and Wild-Caught Catfish from Southern Mississippi. Organohalogen Compounds. 68: 2527-2530.  Dioxin 2006. August 21-25, 2006. Oslo, Norway.

Barone S Jr., Brown RC, Euling S, Cohen Hubal E, Kimmel CA, Makris S, Moya J, Selevan SG, Sonawane B, Thomas T, and Thompson CM. 2006. Visión General De La Evaluación Del Rieso En Salud Infantil Empleando Un Enfoque Por Etapas De Desarrollo. Acta Toxicol. Argent. 14(Sup), 7–10.

Ferriby, L.L., E.S. Williams, W.J. Lukesemburg, D.J. Paustenbach, L.C. Haws, L.S. Birnbaum, and M. Harris. 2006. Comparing PCDDs, PCDFs, and Dioxin-Like PCBs in Farm-Raised and Wild-Caught Catfish from Southern Mississippi.  Dioxin 2006. August 21-25, 2006. Oslo, Norway.

Becker DS, Long ER, Proctor DM, Ginn TC. 2006. Toxicity and bioavailability of chromium in sediments associated with chromite ore processing residue.  Environ Toxicol Chem. 25(10):2576–2583.

Ferriby, L.L., K. Franke, K.M. Unice, P. Scott, L.C. Haws, M. Harris, and D.J. Paustenbach. 2006. Serum reference levels of PCDD/Fs and dioxin-like PCBs stratified by race/ethnicity, gender and age for the general U.S. population. American Public Health Association Annual Meeting and Exposition. November 4-8, 2006. Boston, MA.

Haws LC, Su S, Harris MA, DeVito M, Walker N, Farland W, Finley B, and Birnbaum L. 2006. Development of a refined database of mammalian relative potency estimates for dioxin-like compounds. Toxicol Sci. 89(1):4-30.

Finster M., MacDonell, M., Bhattacharyya, M., Haroun L., Peterson J., and Perry, C. Environmental fate and cumulative risk context for cleanup programs. Society for Risk Analysis’ Annual Meeting. December 3-6, 2006. Baltimore, MD.

Paustenbach DJ, Fehling K, Scott P, Harris M, and Kerger B. 2006. Identifying soil clean-up criteria for dioxin in urban residential soils: How have 20 years of research and risk assessment experience affected the analysis? J Toxicol Environ Health, Part B. 9:87-145.

Gough, M., D. Paustenbach, B. Kerger, H. Leung, P. Scott, and M. Harris. 2006. Dioxin and diabetes does the current weight of evidence demonstrate a relationship. Society of Toxicology. March 5-9, 2006. San Diego, CA.

Staskal DF, Diliberto JJ and Birnbaum LS. 2006. Impact of repeated exposure on the toxicokinetics of BDE 47 in mice. Toxicol Sci. 89:380-5.

Harris, M., L. Ferriby, J. Knutsen, P. Nony, K. Unice, and D. Paustenbach. 2006. Evaluation of PCDD/F and dioxin-like PCB serum concentration data from the 2001-2002 National Health and Nutrition Examination Survey in the United States. Society of Toxicology. March 5-9, 2006. San Diego, CA.

Staskal DF, Diliberto JJ, and Birnbam LS. 2006. Disposition of BDE 47 in developing mice. Toxicol Sci. 90:309-16.

Haws, L. The Use of Toxic Equivalency Factors to Assess Potential Human Health Risks Posed by Dioxin-like Compounds: Keeping Up With the Science. Presented at Michigan State University, Toxicology Program Seminar Series. September 26, 2006.

Staskal DF, Hakk H, Bauer D, Diliberto JJ, and Birnbam LS. 2006. Toxicokinetics of Polybrominated diphenyl ether congeners 47, 99, 100, and 153 in mice. Toxicol Sci. 94:28-37.

Haws, L.C., P.K. Scott, K.M. Unice, M. Gough, M.A. Harris, D.F. Staskal, D.J. Paustenbach, and M. Pavuk. Are Dioxin Body Burdens Surrogates for Other Risk Factors in Associations Between Dioxin and Diabetes?  Dioxin 2006. August 21-25, 2006. Oslo, Norway.

Van den Berg M, Birnbaum L, Denison M, De Vito M, Farland W, Feeley M, Fiedler H, Hakansson H, Hanberg A, Haws LC, Rose M, Safe S, Schrenk D, Tohyama C, Tritscher A, Tuomisto J, Tysklind M, Walke Nr, and Peterson RE. 2006. The 2005 World Health Organization Reevaluation of Human and Mammalian Toxic Equivalency Factors for Dioxins and Dioxin-Like Compounds. Toxicol Sci. 93(2):223-241.

Jackson MA, Lea I, Rashid A, Peddada SD, Dunnick JK. 2006. Genetic alterations in cancer knowledge system: Analysis of gene mutations in mouse and human liver and lung tumors. Toxicol Sci 90:400–418.

Haws, L.C., M.J. DeVito, L.S. Birnbaum, N.J. Walker, P.K. Scott, K.M. Unice, M.A. Harris, W.H. Farland, B.L. Finley, and D.F. Staskal. An Alternative Method for Establishing TEFs for Dioxin-like Compounds. Part 2. Development of An Approach To Quantitatively Weight the Underlying Potency Data. Dioxin 2006. August 21-25, 2006. Oslo, Norway.

Paustenbach, D.J., M.. Harris, L.L. Ferriby, E.S. Williams, L.C. Haws, K.M. Unice, and P.K. Scott. 2006. Development of PCDD/F TEQ serum reference values for the U.S. population for use in evaluating biomonitoring results. Dioxin 2006. August 21-25, 2006. Oslo, Norway.

Richardson, V.M., D.F. Staskal, J.J. Diliberto, and L.S.Birnbaum. 2006. Effects of BDE 47 on nuclear receptor regulated genes and implications for thyroid hormone disruption. 45th Annual Meeting of Society for Toxicology. March 5-9, 2006. San Diego, CA.

Scott, P.K., L.C. Haws, D.F. Staskal, L.S. Birnbaum, N.J. Walker, M.J. DeVito, M.A. Harris, W.H. Farland, B.L. Finley, and K.M. Unice. An Alternative Method for Establishing TEFs for Dioxin-like Compounds. Part 1. Evaluation of Decision Analysis Methods for Use in Weighting Relative Potency Data. Dioxin 2006. August 21-25, 2006. Oslo, Norway.

Staskal, D.F., K.M. Unice, N.J Walker, M.J. DeVito, L.S. Birnbaum, P.K. Scott, M.A. Harris, W.H. Farland, B.L. Finley, and L.C. Haws. An Alternative Method for Establishing TEFs for Dioxin-like Compounds. Part 3. Development of Weighted Distributions of REPs for PCB126 and 2,3,4,7,8-PeCDF. Dioxin 2006. August 21-25, 2006. Oslo, Norway.

Staskal, D.F., L.L. Ferriby, E.S. Williams, W.J. Luksemburg, L.C. Haws, L.S. Birnbaum, D.J. Paustenbach, and M. Harris. 2006. Polybrominated diphenyl ethers in southern Mississippi catfish. Dioxin 2006. August 21-25, 2006. Oslo, Norway.

Staskal, D.F., J.J. Diliberto, and L.S. Birnbaum. 2006. Effect of age on the tissue distribution of BDE 47 in mice. 45th Annual Meeting of Society for Toxicology. March 5-9, 2006. San Diego, CA.

Urban, J.D., J. Jin, and R.B. Mailman. 2006. N27 dopaminergic cell line: A useful model for studying the mechanisms of action of functionally selective dopaminergic compounds. 45th Annual Meeting of Society for Toxicology. March 5-9, 2006. San Diego, CA.

Van den Berg, M., L. Birnbaum, M. Denison, M. De Vito, W. Farland, M. Feeley, H. Fiedler, H. Hakansson, A. Hanberg, L.C. Haws, M. Rose, S. Safe, D. Schrenk, C. Tohyama, A. Tritscher, J. Tuomisto, M. Tysklind, N. Walker, and R.E. Peterson. 2006. Human And Mammalian Toxic Equivalency Factors For Dioxins And Dioxin-like Compounds: The WHO 2005 Re-Evaluation.  Dioxin 2006. August 21-25, 2006. Oslo, Norway.

Paustenbach, D.J., L.L.F. Scott, L.M. Nguyen, K.M. Unice, P. Scott, L.C. Haws, and M. Harris. 2007. Referent Concentrations of PCDD/Fs and Dioxin-like PCBs in Sera of Persons in the U.S. Based on the New WHO 2006 TEFs and 2001-2002 NHANES Data. Ann Epidemiol. 17:734.

Mounho, B. Chronic Toxicity Studies for Monoclonal Antibodies: Avastin® and Erbitux®. Presented at BioSafe/FDA meeting. 2006.

Mounho, B. The Use of Toxicokinetics and Toxicodynamics in the Safety Assessment and Development of Small and Large Molecule Therapeutic Products. Presenter and Symposium Chair: American College of Toxicology Annual Meeting. 2006.

Mounho, B. Immunomodulation in Nonhuman Primates. Presented at Pharmaceutical Education Associates Immunotoxicology IV Meeting. 2006.

Bauer, D., D.F. Staskal, J.J. Diliberto, and L.S. Birnbaum. 2005. Disposition of BDE 99 and BDE 153 in female mice. Society of Toxicology. March 6-10, 2005. New Orleans, LA.

Connor, K., M. Harris, M. Edwards, A. Chu, G. Clark, and B. Finley. 2004. Estimating the total TEQ in human blood from naturally-occurring vs. anthropogenic dioxins: a dietary study.  DIoxin 2005. August 21-26, 2005. Toronto, Canada.

Harris, M., and B. Finley. Estimating the total TEQ in human blood from naturally-occurring vs. anthropogenic dioxins: a dietary study. Society of Toxicology. March 6-10, 2005. New Orleans, LA.

Harris, M., B. Finley, P. Scott. Development of a Relative Estimate of Potency Distribution for 2,3,7,8-TCDF. Dioxin 2005. August 21-26, 2005. Toronto, Canada.

Haws, L. Evaluating Potential Health Risks Posed By PCDDs, PCDFs, and Dioxin-like PCBs: An Approach for Improving the Toxicity Equivalency Factor (TEF) Methodology. 30th Annual Winter Meeting of the Toxicology Forum. February 2, 2005. Washington, DC.

Mounho, B. Differences between small molecules and biological therapeutic drug products. Society of Toxicology. March 6-10, 2005. New Orleans, LA.

Paustenbach, D.J., K. Fehling, M. Harris, P. Scott, B.D. Kerger. Identifying Soil Clean-up Criteria for Dioxin in Residential Soils: How Has 20 Years of Research and Risk Assessment Experience Impacted The Analysis? DIoxin 2005. August 21-26, 2005. Toronto, Canada.

Perry, C.S., Garcia, S., Collie, S., MacDonell, M., Femi Adeshina, and Cynthia Sonich-Mullin: Application of provisional advisory levels for EPA National Homeland Security Research Center’s secure, internet-based rapid risk tool. Society for Risk Analysis’ Annual Meeting. December 4-7, 2005. Orlando, FL.

Garabrant G, James RC. 2005. Trichloroethylene and cancer in humans: Recognizing the need for an evidence based analysis. Toxicology. 212:80-84.

Grasty RC, Bjork JA, Wallace KB, Wolf DC,  Lau CS, Rogers JM. 2005. Effects of prenatal perfluorooctane sulfonate (PFOS) exposure on lung maturation in the perinatal rat. Birth Defects Res B Dev Reprod Toxicol. Oct; 74(5):405-16.

Guzelian PS, Victoroff M, Halmes NC, James RC and Guzelian CP. 2005. Evidence-based toxicology: A comprehensive framework for causation. Hum. Exp. Toxicol. 24:161-201.

Staskal DF, Diliberto JJ, DeVito MJ and Birnbaum LS. 2005. Inhibition of Human and Rat CYP1A2 by TCDD and Dioxin-like Chemicals. Toxicol Sci. 84: 225-31.

Staskal DF, Diliberto JJ, DeVito MJ, and Birnbaum LS. 2005. Toxicokinetics of BDE 47 in Female Mice: Effects of Dose, Route of Exposure, and Time. Toxicol Sci. 83: 215-23.

Urban, J.D. and R.B. Mailman. 2005. Characterization of the N27 dopaminergic cell line as a model for elucidating the actions of functionally selective dopaminergic ligands. 35th Annual Neuroscience Meeting. November 12-16, 2005. Washington, DC.

Grasty RC, N Roberts, G Klinefelter, JA Bjork, KB Wallace, CS Lau, and JM Rogers (2005). Effects of prenatal perfluorooctanesulfonate (PFOS) exposure on lung maturation in the perinatal rat. Birth Defects Res A Clin Mol Teratol 73: 314.

Connor, K., M. Harris, M. Edwards, A. Chu, G. Clark, and B. Finley. 2004. Estimating the total TEQ in human blood from naturally-occurring vs. anthropogenic dioxins: A dietary study.  Dioxin 2004. September 6-10, 2004. Berlin, Germany.

Gay EA, Urban JD, Nichols DE, Oxford GS, and Mailman RB. 2004. Functional selectivity of D2 receptor ligands in a Chinese hamster ovary hD2L cell line: evidence for induction of ligand-specific receptor states. Mol Pharmacol. 66 (1): 97 – 105.

Haws, L. Roundtable: Is it Time to Reevaluate the Toxic Equivalency Factors for PCDDs, PCDFs, and Dioxin-Like PCBs? The Use of Toxicity Equivalence Factors (TEFs) for PCDDs, PCDFs, and Dioxin-Like PCBs in Risk Assessment: Improving the Process. Dioxin 2004. September 6-10, 2004. Berlin, Germany.

Proctor DM, Panko JP, Liebig EW, Paustenbach, DJ. 2004. Estimating historical occupational exposure to airborne hexavalent chromium in a chromate production plant: 1940–1972. Occup Environ Hyg. 1:752–767.

Haws, L., M. Harris, S. Su, L. Birnbaum, M. DeVito, W. Farland, N. Walker, K. Connor, A.Santamaria, and B. Finley. Development of a refined database of relative potency estimates to facilitate better characterization of variability and uncertainty in the current mammalian TEFs for PCDDs, PDCFs, and dioxin-like PCBs. Dioxin 2004. September 6-10, 2004. Berlin, Germany.

Schecter, A, Papke O, Tung KC, Staskal DF, and Birnbaum L. 2004. Polybrominated diphenyl ether contamination of United States food. Environ Sci Technol. 38(20): 5306-11.

Haws, L., M. Harris, S. Su, N. Walker, L. Birnbaum, M. DeVito, W. Farland, K. Connor, A. Santamaria, and B. Finley. A preliminary approach to characterizing variability and uncertainty in the mammalian PCDD/F and PCB TEFs. Dioxin 2004. September 6-10, 2004. Berlin, Germany.

Thompson CM, Wojno H, Greiner E, May EL, Rice KC, and Selley DE. 2004. Activation of G-proteins by Morphine and Codeine Congeners: Insights to the Relevance of O- and N-Demethylated Metabolites at μ- and δ-Opioid Receptors. Journal of Pharmacology and Experimental Therapeutics. 308(2), 547–554.

Perry, C.S. and Morton, E. Lessons learned from creating integrated Excel models to calculate human health screening values. Society for Risk Analysis’ Annual Meeting. December 5-8, 2004. Palm Springs, CA.

Warren DA, Kerger BD, Britt JK and James RC. 2004. Development of an oral cancer slope factor for Aroclor 1268. Regul. Toxicol. Pharmacol. 40:42-53.

Staskal, D.F., J.J. Diliberto, M.J. DeVito, and L.S. Birnbaum. 2004. Tissue distribution and elimination of BDE 47 in mice following a single oral dose.  Dioxin 2004. September 6-10, 2004. Berlin, Germany.

Staskal, D.F., J.J. Diliberto, M.J. DeVito, and L.S. Birnbaum. 2004. Disposition of 2,2’,4,4’-Tetrabromodiphenylether (BDE 47) in Female Mice. 43rd Annual Meeting of Society for Toxicology. March 21-25, 2004. Baltimore, MD.

Urban, J.D., E.A.Gay, and R.B. Mailman. 2004. Functional selectivity as a mechanism of action of newer atypical antipsychotic drugs. 34th Annual Neuroscience Meeting. October 23-27, 2004. San Diego, CA.

Lea IA, Widgren EE, O’Rand MG. 2004. Association of sperm protein 17 with A-kinase anchoring protein 3 in flagella. Reprod Biol Endocrinol 2:57.

Grasty RC, Roberts N, Grey BE, Lau C, Rogers JM. (2004). Effects of prenatal exposure to perfluorooctane sulfonate on the developing lung in the rat. 43rd Annual Meeting of Society for Toxicology. March 21-25, 2004. Baltimore, MD.

Urban, J.D., E.A. Gay, and R.B. Mailman. 2004. Decreased neurological side-effects with aripiprazole: a result of functional selectivity of the D2 receptor? 43rd Annual Meeting of Society for Toxicology. March 21-25, 2004. Baltimore, MD.

Grasty RC, Roberts N, Grey BE, Lau C, Rogers JM. (2004). Perfluorooctane sulfonate (PFOS) alters lung development in the neonatal rat. Birth Defects Research, Part A, 70(5), 42.

Birnbaum LS, and Staskal DF. 2004. Brominated Flame Retardants: Cause for Concern? Environ Health Perspect. 112: 9-17.

Haws, L. Combustion Risk Modeling and Assessment. Presented at the Texas Commission on Environmental Quality Workshop on Hazardous Waste Combustion. May 7, 2003. Austin, TX.

Birnbaum LS, Staskal DF, and Diliberto JJ. 2003. Health effects of polybrominated dibenzo-p-dioxins (PBDDs) and dibenzofurans (PBDFs). Environ Inter. 29: 855-860.

Perry, C.S. Process for development of protective concentration levels for remediation sites in Texas.Presented at Society for Environmental Toxicology and Chemistry (SETAC) meeting. November 9-13, 2003. Austin, TX.

Crump C, Crump KS, Hack E, Luippold RS, Mundt KA, Panko JP, Liebig EW, Paustenbach DJ, Proctor DM. 2003. Dose-response and risk assessment of airborne hexavalent chromium and lung cancer mortality. Risk Anal. 23(6):1155−1171.

Staskal, D.F., M.J. DeVito, D.G. Ross, and L.S. Birnbaum. 2003. A Comparison of the metabolism of methoxyresorufin, acetanilide, and caffeine in rat and human CYP1A2 SUPERSOMES. The Toxicologist.

Grasty RC, Grey BE, Wolf DC,  Lau CS, Rogers JM. 2003. Prenatal window of susceptibility to perfluorooctane sulfonate-induced neonatal mortality in the Sprague-Dawley rat. Birth Defects Res (Part B) Dev Reprod Toxicol. Dec;68(6):465-71.

Staskal, D.F., M.J. DeVito, D.G. Ross, and L.S. Birnbaum. 2003. Caffeine, Acetanilide, and Methoxyresorufin Metabolism by Rat and Human CYP1A2 SUPERSOMES and their Inhibition by 2,3,7,8,-Tetrachlorodibenzo-p-dioxin (TCDD). Organohalogen Compounds.

Luippold RS, Mundt KA, Austin RP, Liebig E, Panko JP, Crump C, Crump K, Proctor DM. 2003. Lung cancer mortality among chromate workers. 2003. Occup Environ Med. 60:451−457.

Grasty RC, Grey BE, Lau CS, Rogers JM. 2003. Window of susceptibility to perfluorooctane sulfonate (PFOS)-induced neonatal mortality in the rat. Birth Defects Research, Part B, 68(3), 5.

Proctor D, Panko J, Liebig E, Mundt K, Buczynski M, Barnhart R, Harris MA, Morgan R, Finley B, and Paustenbach D. 2003. Workplace concentrations of airborne hexavalent chromium for the Painesville, Ohio chromate production plant. Appl Occ Environ Hyg J. 18(6):430-449.

Lansita, JA, Merok, JR, and Sherley, JL. 2003. “Physicochemical Demonstration of Immortal DNA Strand Segregation,” in “Mechanisms of Toxicity, Carcinogenesis, Cancer Prevention and Cancer Therapy: Abstracts of the Seventeenth Aspen Cancer Conference,” Tox. Path., 31, 163-164.

Scott P, Petura J, and Harris MA. 2003. Derivation of a liquid to solid ratio for ASTM method D3987 85 for soils containing chromite ore processing residue using selected unsaturated zone models. Soil Sed Contam. 12(4):443-480.

Merok, JR, Tunstead, JR, Lansita, JA, and Sherley, JL. 2003. Demonstration of an immortal DNA strand mechanism in cells that cycle with asymmetric stem cell kinetics–Implications for mechanisms of human cancer and aging. In: Mechanisms of toxicity, carcinogenesis, cancer prevention and cancer therapy: Abstracts of the Seventeenth Aspen Cancer Conference. Toxicol Pathol 31:165-166.

Proctor, D., M. Harris, and D. Rabbe. 2002. Chapter 9: A risk assessment of chromium contaminated soils: ten years of research to characterize the health hazards, in Human and Ecological Risk Assessment: Theory and Practice. D. Paustenbach (ed.). pp. 485–555.

Haws, L. Permitting of Hazardous Waste Combustion Facilities in the State of Texas: Human Health Risks Associated with Fugitive Emissions Sources. Presented at the Texas Chemical Council Quarterly Meeting. August 1, 2002. Houston, TX.

Grant RL, Rodriguez R, Hofelt CS, and Haws LC. 2002. Shortcomings in USEPA’s approach for predicting risk due to consumption of animal food products impacted by air emissions from hazardous waste combustion facilities: a case study involving phthalates. Human Ecol Risk Assess. 8(5):1137-1154.

Sanatamaria, A., L. Ferriby, M. Harris, and D. Paustenbach. Use of biomarkers in health risk assessment. In Toxicologic Biomarkers, Anthony DeCaprio (ed.). Informa Healthcare. pp. 85-109.

Haws, L. Texas Risk Reduction Program Rule-The Basics. Question and Answer Forum Panelist. Presented at the Texas Natural Resource Conservation Commission Environmental Trade Fair. Waste Remediation Track. May 7, 2002. Austin, TX.

Roberts SM, Jordan KE, Warren DA, Britt JK and James RC. 2002. Evaluation of the carcinogenicity of 1,1-Dichloroethylene (Vinylidene Chloride). Regul. Toxicol. Pharmacol. 35:44-55.

Haws, L. Toxicology and Risk Assessment Resources and Practices in the State of Texas. Presented at the USEPA Region 6 States Risk Assessment Roundtable. April 5, 2002. Dallas, TX.

Merok, JR, Lansita, JA, Tunstead, JR, Sherley, JL. 2002. “Cosegregation of Chromosomes Containing Immortal DNA Strands in Cells that Cycle with Asymmetric Stem Cell Kinetics,” Cancer Res., 62, 6791-6795.

Perry, C.S. TRRP Rule – The basics part 2: human health PCLs and look-up tables. 2002 TNRCC Environmental Trade Fair presentation and paper.

Hofelt CS, Honeycutt M, McCoy JT, and Haws LC. 2001. Development of a metabolism factor for polycyclic aromatic hydrocarbons for use in multipathway risk assessments for hazardous waste combustion facilities. Reg Toxicol Pharmacol. 33:60-65.

Grasty RC, Grey BE, Thibodeaux J, Lau C, Rogers JM. (2002). Critical period for increased neonatal mortality induced by perfluorooctane sulfonate (PFOS) in the rat. The Toxicologist 66 (1-S), 118.

Strobel HW, Thompson CM, Antonovic L. 2001. Cytochromes P450 in brain: function and significance. Current Drug Metabolism. 2(2), 199–214.

Staskal, D.F., M.J. DeVito, D.G. Ross, and L.S. Birnbaum. 2002. Inhibition of human and rat CYP1A2 by TCDD and dioxin-like chemicals. The Toxicologist.

Lea IA, Widgren EE, O’Rand MG. 2002. Analysis of recombinant mouse zona pellucida protein 2 (ZP2) constructs for immunocontraception. Vaccine 20(11–12):1515–1523

Haws, L. Risk Assessment Coordination Between EPA and States Panelist. Presented at the USEPA Regional Risk Assessors Annual Conference. May 25, 2001. Bandera, TX.

Haws, L. Texas Risk Reduction Program Rule-Practical Applications. Question and Answer Forum Panelist. Presented at the Texas Natural Resource Conservation Commission Environmental Trade Fair. Waste Remediation Track. April 30, 2001. Austin, TX.

Skaggs, Jr. M.M., and M. Harris. 2001. A management trend: towards special remedial organizations. SPE/EPA/DOE Exploration and Production Environmental Conference. February 26-28, 2001. San Antonio, TX.

Tachovsky, J. A., J. T. McCoy, and L. C Haws. Development and implementation of probabilistic risk assessment protocol in Texas. Presented at the 94th Conference of the AWMA. June 24-28, 2001. Orlando, FL.

Lea IA, Sivashanmugam P, O’Rand MG. 2001. Zonadhesin: Characterization, localization, and zona pellucida binding. Biol Reprod 65(6):1691–700.

James, R.C., S.M. Roberts and P.L. Williams.  General principles of toxicology.  In:  Principles of Toxicology: Environmental and Industrial Applications, Second Edition. P.L. Williams, R.C. James and S.M. Roberts (Eds.), John Wiley & Sons, Inc., New York, NY. pp. 3-34,  2000.

Grant, R.L., D. Morrill, D. Manis, A. Tachovsky, and L.C. Haws. 2000. The Texas combustion project: review of trial burn/risk burn plans and reports. Proceedings, International Conference on Incineration and Thermal Treatment Technologies. May 8–12, 2000. Portland, OR.

Finley BL, Proctor DM, Harris MA, and Fowler JF. 2000. Letter to the editor. American J Contact Derm. 123-125.

Roberts, S.M., R.C. James and M.R. Franklin.  Hepatotoxicity: Toxic effects on the liver.  In: Principles of Toxicology: Environmental and Industrial Applications, Second Edition.  P.L. Williams, R.C. James and S.M. Roberts (Eds.), John Wiley & Sons, Inc., New York, NY. pp. 111-128,  2000.

Tachovsky, J.A., L.C. Haws, C.S. Hofelt, and J.T. McCoy. 2000. Risk assessment implementation in Texas. Proceedings, International Conference on Incineration and Thermal Treatment Technologies. May 8–12, 2000. Portland, OR.

Smith DM, Grasty RC, Theodosiou NA, Tabin CJ, Nascone-Yoder NM.  2000. Evolutionary relationships between the amphibian, avian, and mammalian stomachs.  Evol Dev. Nov-Dec;2(6):348-59.

James, R.C. and C.J. Saranko.  Chemical Carcinogenesis.  In: Principles of Toxicology:  Environmental and Industrial Applications, Second Edition.  P.L. Williams, R.C. James and S.M. Roberts (Eds.), John Wiley & Sons, Inc., New York, NY. pp. 265-324,  2000.

Thompson CM, Capdevila JH, and Strobel HW. 2000. Recombinant P450 2D18 Metabolism of Dopamine and Arachidonic Acid. Journal of Pharmacology and Experimental Therapeutics. 294(3), 1120–1130.

James, R.C., D.A. Warren, N.C. Halmes and S.M. Roberts.  Risk Assessment.  In: Principles of Toxicology:  Environmental and Industrial Applications, Second Edition.  P.L. Williams, R.C. James and S.M. Roberts (Eds.), John Wiley & Sons, Inc., New York, NY. pp. 437-477,  2000.

Haws, L. Permitting of Hazardous Waste Combustion Facilities in the State of Texas: Risk Assessment Procedures and Status Update. Presented at the Texas Chemical Council Quarterly Meeting. September 15, 1999. Houston, TX.

Harris, M., and M.M. Skaggs. A review of chromium treatment technologies, YPF Environmental Congress. September 1998. Buenos Aires, Argentina.

Gerhardt B, Kordas TJ, Thompson CM, Patel P, and Vida TV. 1998. The vesicle transport protein, Vps33p, is an ATP binding protein that localizes to the cytosol in an energy dependent manner. Journal of Biological Chemistry. 273(25), 15818–15829.

Fraiser, L.H., J.A. Tachovsky, M.E. King, J.T. McCoy, and L.C. Haws. 1998. Hazardous waste combustion risk assessment experience in the state of Texas. Proceedings, International Conference on Incineration and Thermal Treatment Technologies Conference. May 11–15, 1998. Salt Lake City, UT.

Thompson CM, Kawashima H, and Strobel HW. 1998. Isolation of partially purified P450 2D18 and characterization of activity towards the tricyclic antidepressants imipramine and desipramine. Archives of Biochemistry and Biophysics. 359(1), 115–121.

Lea IA, Kurth B, O’Rand MG. 1998. Immune response to immunization with sperm antigens in the macaque oviduct. Biol Reprod 58(3):794–800.

Skaggs, Jr. M.M., and M.A. Harris. 1997. Risk management strategies for site closure actions. National Association for Environmental Management. October 1997. Dallas, TX.

Costa M, Zhitkovich A, Harris MA, Paustenbach D, and Gargas M. 1997. DNA-Protein crosslinks produced by various chemicals in cultured human lymphocytes. J Toxicol Environ Health.

Kawashima H, Kusunose E, Thompson CM, and Strobel HW. 1997. Protein expression, characterization, and regulation of CYP4F4 and CYP4F5 cloned from rat brain. Archives of Biochemistry and Biophysics. 347(1), 148–154.

Roberts SM, DeMott R and James RC. 1997. Adrenergic modulation of hepatotoxicity.  Drug Metab. Rev. 29: 329-353.

Calabrese EJ, Stanek EJ, James RC and Roberts SM. 1997. Soil ingestion: A concern for acute toxicity in children.  Environ. Health Perspect. 105:1354-1358.

Scott P, Finley B, Harris MA, and Rabbe D. 1997. Determination of background airborne hexavalent chromium concentrations in industrial areas. J Air Waste Manage. Assoc. 47:592-600.

Thompson CM, Bernhard AE, and Strobel HW. 1997. Barbiturate-induced expression of neuronal nitric oxide synthase in the rat cerebellum. Brain Research. 754, 142–146.

Lea IA, Adoyo P, O’Rand MG. 1997. Autoimmunogenicity of the human sperm protein Sp17 in vasectomized men and identification of linear B cell epitopes. Fertil Steril 67(2):355–361.

O’Rand MG, Lea IA. 1997. Designing an effective immunocontraceptive. J Reprod Immunol 36(1–2):51–59; Review.

Adoyo PA, Lea IA, Richardson RT, Widgren EE, O’Rand MG. 1997. Sequence and characterization of the sperm protein Sp17 from the baboon. Mol Reprod Dev 47(1):66–71.

Fraiser, L.H., L.G. Lund, K.H. Tyndall, M.E King, D.A. Schultz, and L.C. Haws. 1996. Case Studies in risk assessment for hazardous waste burning cement kilns. Air and Waste Management Association Specialty Conference. Waste Combustion in Boilers and Industrial Furnaces. March 25-26, 1996. Kansas City, MO.

Ramu K, Perry CS, Ahmed T, Pakenham G, and Kehrer JP. 1996. Studies on the basis for the toxicity of acrolein mercapturates.  Toxicology and Applied Pharmacology. 140(2):487-498.

Lund, L.G., L.C. Haws, J.T. McCoy, L.C. Carlisle, D. Brymer, D. Thompson, and J.M. Wiersema. 1996. Addressing community concerns about industrial emissions and burning of hazardous waste in cement kilns: a summary of environmental data. Air and Waste Management Association Specialty Conference. Waste Combustion in Boilers and Industrial Furnaces. March 25-26, 1996. Kansas City, MO.

Sauers L and Perry C.1996. Regulatory affairs – a growing opportunity for toxicologists. SOT Communiqué, May/June 1996.

McCoy, J.T., L.C. Haws, L.C. Carlisle, J.M. Wiersema, D. Carmichael, D., and S. Mgebroff. 1996. Soil sampling and analysis for PCDDs/PCDFs Downwind of combustion sources in six Texas communities. Society of Environmental Toxicology and Chemistry Annual Meeting Abstract Book.

Lea IA, Richardson RT, Widgren EE, O’Rand MG. 1996. Cloning and sequencing of cDNAs encoding the human sperm protein, Sp17. Biochim Biophys Acta 1307(3):263–266.

Fraiser, L.H., L.G. Lund, K.L. Hueske, and L.C. Haws. 1995. Indirect risk assessment: case studies of hazardous waste combustors. Society of Toxicology Annual Meeting. March 5-9, 1995. Baltimore, MD. The Toxicologist 30:31

Huber KM, Mauk MD, Thompson CM, and Kelly PT. 1995. A critical period of protein kinase activity after tetanic stimulation is required for the induction of long-term potentiation. Learning & Memory. 2, 81–100.

Perry CS, Liu XL, Lund LG, and Kehrer JP. 1995. Differential toxicities of cyclophosphamide and its glutathione metabolites to A549 cells. Toxicol. in Vitro. 9:21-26.

Roberts SM, Harbison RD, Westhouse RA and James RC. 1995. Exacerbation of carbon tetrachloride ¬induced liver injury in the rat by methamphetamine.  Toxicol. Lett. 76:77–83.

Roberts SM, Harbison RD and James RC. 1995. Mechanistic studies on the potentiation of carbon tetrachloride hepatotoxicity by methamphetamine.  Toxicology 97:49–57.

Williams CA, James RC and Freeman RW. 1995. Using the EPC approach to develop health based soil and water concentrations for environmental chemicals. Regul. Toxicol. Pharmacol. 22:64–75.

Borgert CJ, S.M. Roberts SM, Harbison RD and James RC. 1995. Influence of soil half–life on risk assessment of carcinogens. Regul Toxicol Pharmacol 22:143–151.

Haws, L. How Are We Implementing the Combustion Strategy and Indirect Risk Assessment? Presented at the Texas Natural Resource Conservation Commission Hazardous Waste Seminar. October 26-27, 1994. Houston, TX.

Gargas M, Norton R, Harris MA, Paustenbach D, and Finley B. 1994. Urinary excretion of chromium following ingestion of chromite ore processing residue in humans: implications for biomonitoring. Risk Anal. 14(6):1019-1024.

Haws, L. Indirect Risk Assessment. Presented at the Sixth Annual Texas Environmental Superconference. August 4-5, 1994. Austin, TX.

Haws LC, Jackson BA, Turnbull D, and Dressler WE. 1994. Two approaches for assessing human cancer risk from disperse blue 1. Reg Toxicol Pharmacol. 19:80-96.

Haws, L. Overview of TNRCC/EPA Concerns, Strategies, and Schedules Concerning Indirect Risk Assessment Requirements. Presented at the Workshop on Risk Assessment and Waste Incineration Facilities. June 28, 1994, Houston, TX, and June 29, 1994. Austin, TX.

James RC, Roberts SM and Williams PL. 1994. Evaluation of the adequacy of the Threshold Limit Value for cyclonite.  Appl. Occup. Environ. Hyg. 9:485–492.

Haws, L. Indirect Risk Workshop. Panel Discussant. Presented at the RCRA Policy Forum. January 31, 1994. Washington, DC.

Roberts SM, Harbison RD and James RC. 1994. Methamphetamine potentiation of carbon tetrachloride hepatotoxicity in mice.  J. Pharmacol. Exp. Ther. 271:1051–1057.

Haws, L. Keynote Address. Presented at the DRE Environmental Services Workshop on EPA’s New Policy of Hazardous Waste Combustion. January 21, 1994. Austin, TX.

Roberts SM, Harbison RD, Roth L and James RC. 1994. Methylphenidate–induced hepatotoxicity in mice and its potentiation by alpha-adrenergic agonist drugs.  Life Sci. 55:269-281.

Williams CA, Jones HD, Freeman RW, Wernke MJ, Williams PL, Roberts SM and James RC. 1994. The EPC approach to estimating safety from exposure to environmental chemicals.  Regul. Pharmacol. Toxicol. 20:259–280.

Borgert, C.J., S.M. Roberts, R.C. James and R.D. Harbison. Perspectives on assessment of risks from dermal exposure to polycyclic aromatic hydrocarbons. In: Health Risk Assessment: Dermal and Inhalation Exposure and Absorption of Toxicants. R.G. Wang, J.B. Kanak and H.I. Maibach (Eds.), CRC Press, Boca Raton, FL. pp. 455-470,  1993.

Haws, L. Principles of Toxicology and Risk Assessment. Presented at the University of Texas at Austin. LBJ School of Public Affairs. September 10, 1993. Austin, TX.

Copeland TL, Paustenbach DJ, Harris MA, and Otani J. 1993. Comparing the results of a Monte Carlo analysis with EPA’s reasonable maximum exposed individual (RMEI): a case study of a former wood treatment site. Reg Toxicol Pharmacol. 18:275-312.

Harris, MA, Zacharewski T, and Safe S. 1993. Comparative potencies of Aroclors 1232, 1248, 1254, and 1260 in male wistar rats—Assessment of the toxic equivalency factor (TEF) approach for polychlorinated biphenyls (PCBs). Fund Appl Toxicol. 20:456-463.

James RC, Busch H, Tamburro CH, Harbison RD, Schell JD and Roberts SM. 1993. Polychlorinated biphenyl exposure and human disease.  J. Occup. Med. 35:136–148.

James RC, Harbison RD and Roberts SM. 1993. Phenylpropanolamine potentiation of acetaminophen-induced hepatotoxicity:  Evidence for a glutathione-dependent mechanism.  Toxciol.  Appl. Pharmacol. 118:159–168.

Roberts, S.M., R.C. James and R.D. Harbison. Cocaine-induced hepatotoxicity.  In: Cocaine: Pharmacology, Physiology and Clinical Strategies.  J.M. Lakosky, M.P. Galloway and F.P. White (Eds.), Telford Press, Boca Raton, FL. pp. 15-33,  1992.

Haws, L. Developmental toxicity of TCDD and related compounds. Presented at the Texas A&M University Faculty of Toxicology Seminar Series. October 12, 1992. College Station, TX.

Roberts SM, Munson JW, James RC and Harbison RD. 1992. An assay for cocaethylene and other cocaine metabolites in liver using high-performance liquid chromatography.  Anal. Biochem. 202:256-261.

Wenning, R.I., D.J. Paustenbach, M.A. Harris, H. Bedbury. Chemometric Analysis of Potential Sources of Polychlorinated Dibenzo-p Dioxin and Dibenzofuran Residues in Surficial Sediments from Newark Bay, New Jersey. Dioxin 1992. August 24-28, 1992. Tampere, Finland.

Roth L, Harbison RD, James RC, Tobin T and Roberts SM. 1992. Cocaine hepatotoxicity: Influence of hepatic enzyme inducing and inhibiting agents on the site of necrosis.  Hepatology 15:934-940.

Wenning, R.I., D.J. Paustenbach, M.A. Harris, H. Bedbury. Sources of PCDD/Fs in Newark Bay Sediments. 13th Annual Meeting of the Society of Environmental Toxicology and Chemistry. November 8-12, 1992. Cincinnati, OH.

Roberts SM, Roth L, Harbison RD and James RC. 1992. Cocaethylene hepatotoxicity in mice.  Biochem. Pharmacol. 43:1989-1995.

Milner GC, James RC and Nye AC. 1992. Human health-based soil cleanup guidelines for diesel fuel No. 2.  J. Soil Contam. 1:103-158.

Wenning RJ, Harris MA, Ungs MJ, Paustenbach DJ, and Bedbury H. 1992. Chemometric comparison of polychlorinated dibenzo-p-dioxin and dibenzofuran residues in surficial sediments from Newark Bay, New Jersey and other industrialized waterways. Arch Environ Contam Toxicol. 22:397-413.

Wenning RJ, Harris MA, Paustenbach DJ, and Bedbury H. 1992. Potential sources of 1,2,8,9-tetrachlorodibenzo-p-dioxin in the aquatic environment. Ecotoxicol Environ Safety. 23(2):133-146.

Zacharewski T, Harris MA, Biegel L, Morrison V, Merchant M, and Safe S. 1992. 6-Methyl-1,3,8-trichlorodibenzofuran (MCDF) as an antiestrogen in human and rodent cancer cell lines: evidence for the role of the Ah receptor. Toxicol Appl Pharmacol. 113:311-318.

Arrellano, L., M. Harris, and S. Safe. 1991. Induction of Cypiai Gene transcription by TCDD in MDA-MB-231 human breast cancer cells. Society of Toxicology 30th Annual Meeting. February 25-March 1, 1991. Dallas, TX.

Couture-Haws L, Harris MW, Lockhart AC, and Birnbaum LS. 1991. Evaluation of the persistence of hydronephrosis induced in mice following in uteri and/or lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Toxicol Appl Pharmacol. 107:402-412.

Copeland, T., M. Harris, B. Finley, and D. Paustenbach. 1991. Health effects and environmental characterization of Octachlorodibenzo-p-dioxin (OCDD): Impact on risk assessment of former wood treatment sites. Society of Toxicology 30th Annual Meeting. February 25-March 1, 1991. Dallas, TX.

Couture-Haws L, Harris MW, McDonald MM, Lockhart AC, and Birnbaum LS. 1991. Hydronephrosis in mice exposed to TCDD-contaminated breast milk: identification of the peak period of sensitivity and assessment of potential recovery. Toxicol Appl Pharmacol. 107:413-428.

Fernandez, P., M. Harris, and S. Safe. 1991. Effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) on T47-D human breast cancer cell lines. Society of Toxicology 30th Annual Meeting. February 25-March 1, 1991. Dallas, TX.

Frankos VH, Schmitt DF, Haws LC, McEvily AJ, Iyengar R, Miller SA, Munro IC, Clydsdale FM, Forbes AL, and Sauer RM. 1991. Generally recognized as safe (GRAS) evaluation of 4-hexylresorcinol for use as a processing aid for the prevention of melanosis in shrimp. Reg Toxicol Pharmacol. 14:202-212.

Harris, M., L. Biegel, T. Zacharewski, S. and Safe, S. 6-methyl-1,3,8-trichlorodibenzofuran (MCDF) as an antiestrogen: effects on nuclear estrogen receptor levels, cell growth and the 17_-Estradiol-induced secretion of proteins in MCF-7 Cells. Society of Toxicology 30th Annual Meeting. February 25-March 1, 1991. Dallas, TX.

Piskorska-Pliszczynska, J, Astroff B, Zacharewski T, Harris MA, Rosengren R, Morrison V, Safe L, and Safe S. 1991. Mechanism of action of 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonists: characterization of 6-[125I]methyl-8-iodo-1,3-dichlorodibenzofuran-Ah receptor complexes. Arch Biochem Biophy. 284(1):193-200.

Harris, M., B. Finley, R. Wenning, and D. Paustenbach. 1991. Evaluation of potential sources of 1,2,8,9-TCDD in aquatic biota from Newark Bay. Society of Toxicology 30th Annual Meeting. February 25-March 1, 1991. Dallas, TX.

Safe S, Astroff B, Harris MA, Zacharewski T, Dickerson R, Romkes M, and Biegel L. 1991. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds as antioestrogens: characterization and mechanism of action. Pharmacol Toxicol. 69:400-409.

Jackson, B.A., L.C. Haws, R.J. Wixtrom, and T.B. Starr. 1991. Secondary mechanisms in carcinogenesis: breaking out of the no-threshold paradigm. American College of Toxicology Annual Meeting. Savannah, Georgia.

Safe S, Harris MA, Biegel L, and Zacharewski T. 1991. Mechanism of Action of TCDD as an antiestrogen in transformed human breast cancer and rodent cell lines. Banbury Report 35: Biological Basis for Risk Assessment of Dioxins and Related Compounds Cold Spring Harbor Laboratory Press. 367-377.

Piskorska-Pliszczynska, J., B. Astroff, T. Zacharewski, M. Harris, R. Rosengren, V. Morrison, L. Safe, and S. Safe. 1991. Mechanism of action of 2,3,7,8-Tetrachlorodibenzo-p-dioxin Antagonists: characterization of [125I]-6-methyl-8-Iodo-1,3-dichlorodibenzofuran-Ah receptor complexes. Society of Toxicology 30th Annual Meeting. February 25-March 1, 1991. Dallas, TX.

Simmons HF, James RC, Harbison RD, Patel DG and Roberts SM. 1991. Examination of the role of catechotamines in hepatic glutathione suppression by cold-restraint in mice.  Toxicology 67:29–40.

Harbison RD, James RC and Roberts SM. 1991. Hepatic glutathione suppression by alpha-adrenoreceptor agonist compounds.  Toxicology 69:279-290.

Lea I, Moore HD, Latchman DS. 1991. Differential expression of the mouse U1a and U1b SnRNA genes is not dependent on sequence differences in the octamer motif. Biochem J 277( Pt 3):719–722.

Roberts SM, Harbison RD, Seng JE and James RC. 1991. Potentiation of carbon tetrachloride hepatotoxicity by phenylpropanolamine.  Toxicol. Appl. Pharmacol. 111:175-188.

Roberts SM, Harbison RD and James RC. 1991. Human microsomal N-oxidative metabolism of cocaine.  Drug Metab. Dispos. 19:1046-1051.

Zacharewski T, Harris MA, and Safe S. 1991. Evidence for a possible mechanism of action of the 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated decrease of nuclear estrogen receptor levels in wild-type and mutant Hepa 1c1c7 cells. Biochem Pharmacol. 41:1931-1939.

Couture, L.A., M.W. Harris, A.M. Clark, and L.S. Birnbaum. 1990. Persistence of hydronephrosis in mice following in utero and/or lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Society of Toxicology Annual Meeting. February 12-16, 1990. Miami Beach, FL. The Toxicologist. 10:313.

Couture-Haws L, Abbott BD, and Birnbaum LS. 1990. A critical review of the developmental toxicity and teratogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin: recent advances in understanding the mechanism. Teratol. 42:619-627.

Harris, M., R. Wenning, B. Finley, and D. Paustenbach. 1990. Evaluation of potential sources of 1,2,8,9-TCDD in aquatic biota from Newark Bay. Society of Environmental Chemistry and Toxicology. November 11-15, 1990. Washington, DC.

Couture LA, Harris MW, and Birnbaum LS. 1990. Characterization of the peak period of sensitivity for the induction of hydronephrosis in C57BL/6N mice following exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Fundam Appl Toxicol. 15:142-150.

Harris, M., T. Zacharewski, S. and Safe, S. 2,3,7,8-Tetrachlorodibenzo-p-dioxin as an antiestrogen: Effects of nuclear estrogen receptor levels in MCF-7 Cells. Society of Toxicology Meeting. February 12-16, 1990. Miami Beach, FL.

Harris MA, Piskorska-Pliszczynska J, Zacharewski T, and Safe S. 1990. Human breast cancer cell lines as models for investigating the effects of TCDD and related compounds. Chemosphere. 20(7-9):1135-1140.

Zacharewski, T., J. Piskorska-Pliszczynska, F. Rosengren, B. Astroff, M. Harris, L. Safe, and S.Safe. 1990. 8-Iodo-1,3-dichlorodibenzofuran (I-MCDF) and 125I-MCDF as a 2,3,7,8-Tetrachlordibenzo-p-dioxin (TCDD) antagonist. Society of Toxicology Meeting. February 12-16, 1990. Miami Beach, FL.

Harris MA, Zacharewski T, Piskorska-Pliszcyznska J, Rosengren R, and Safe S. 1990. Structure-dependent induction of aryl hydrocarbon hydroxylase activity in C57BL/6 Mice by 2,3,7,8-tetrachlordibenzo-p-dioxin and related congeners: mechanistic studies. Toxicol Appl Pharmacol. 105:243-253.

Harris MA, Zacharewski T, and Safe S. 1990. Effects of 2,3,7,8-tetrachorodibenzo-p-dioxin and related compounds on the occupied nuclear estrogen receptor in MCF-7 human breast cancer cells. Cancer Res. 50:3579-3584.

Randerath K, Putman KL, Randerath E, Harris MA, Zacharewski T, and Safe S. 1990. Effects of 2,3,7,8-TCDD and related compounds on the levels of age-dependent I-spot DNA adducts in the liver of female and male Sprague-Dawley rats. Chemosphere. 20(7-9):1049-1052.

Randerath K, Putman KL, Randerath E, Zacharewski T, Harris MA, and Safe S. 1990. Effects on 2,3,7,8-tetrachlorodibenzo-p-dioxin on I-compounds in hepatic DNA of Sprague-Dawley rats: sex specific effects and structure-activity relationships. Toxicol Appl Pharmacol. 103:271-280.

Roberts SM, Pounds JG and James RC. 1990. Cocaine toxicity in cultured rat hepatocytes.  Toxicol. Lett. 50: 283-288.

Simmons HF, James RC, Harbison RD and Roberts SM. 1990. Depression of glutathione by cold-restraint in mice.  Toxicology 61:59-71.

Safe S, Harris MA, Zacharewski T, and Biegel L. 1990. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) as an antiestrogen in human breast cancer cells: mechanistic studies. Proceedings Dioxin `90, Eco-Informa Press. Bayreuth, Germany, 1:137-140.

Couture, L.A., M.W. Harris, and L.S. Birnbaum. Characterization of TCDD-induced hydronephrosis relative to cleft palate in C57BL/6N Mice. Presented at the Society of Toxicology Annual Meeting. February 27-March 3, 1989. Atlanta, GA.

Biegel L, Harris MA, Davis D, Rosengren R, Safe L, and Safe S. 1989. 2,2′,4,4′,5,5′-hexachlorobiphenyl as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist in C57BL/6J mice. Toxicol Appl Pharmacol. 97:561-571.

Harris, M., M. Romkes, and S. Safe. Human Breast Cancer Cells as Models for Investigating Ah Receptor Mediated Processes. Dioxin ’89. September 17-22, 1989. Toronto, Canada.

Birnbaum LS, Couture LA, and Elwell MR. 1989. Subchronic effects of exposure to Octachlorodibenzo-p-dioxin (OCDD). Chemosphere. 18(1-6):389-390.

Harris, M., M. Romkes, and S. Safe. Human breast cancer cells as models for investigating ah receptor mediated processes. Society of Toxicology 28th Annual Meeting. February 27-March 3, 1989. Atlanta, GA.

Couture LA, Harris MW, and Birnbaum LS. 1989. Developmental toxicity of 2,3,4,7,8-pentachlorodibenzofuran (4-PeCDF) in the Fischer 344 rat. Fundam Appl Toxicol. 12:358-366.

Zacharewski, T., M. Harris, and S. Safe. 1989. Structure dependent induction of aryl hydrocarbon hydroxylase of TCDD and related compounds: mechanistic studies. Society of Toxicology 28th Annual Meeting. February 27-March 3, 1989. Atlanta, GA.

Harris, MA, Piskorska-Pliszczynska J, Zacharewski T, Romkes M, and Safe S. 1989. Structure-dependent induction of aryl hydrocarbon hydroxylase in human breast cancer cell lines and characterization of the Ah receptor. Cancer Res. 49:4531-4535.

Randerath, K., K.L. Putman, E. Randerath, M. Harris, T. Zacharewski, and S. Safe. Effects of 2,3,7,8-TCDD and related compounds on the levels of age-dependent i-spot DNA adducts in the liver of female and male Sprague-Dawley rats. Dioxin ’89. September 17-22, 1989. Toronto, Canada.

Harris MA, Zacharewski T, Astroff B, Kamps C, and Safe S. 1989. Characterization of 6-methyl-1,3,8-trichlorodibenzofuran (MCDF) as a 2,3,7,8-TCDD antagonist in male rats: induction of monooxygenases. Chemosphere. 19:769-772.

Harris MA, Zacharewski T, Astroff B, and Safe S. 1989. Partial antagonism of 2,3,7,8-tetrachlorodibenzo-p-dioxin mediated induction of aryl hydrocarbon hydroxylase by 6-methyl-1,3,8-trichlorodibenzofuran: mechanistic studies. Mol Pharmacol. 35:729-735.

Kerger BD, Roberts SM, Harbison RD and James RC. 1989. Antagonism of bromobenzene-induced hepatotoxicity by the a-adrenoreceptor blocking agents, phentolamine and idazoxan: Role of hypothermia.  Toxicol. Appl. Pharmacol. 97:360-369.

Skoulis NP, James RC, Harbison RD and Roberts SM. 1989. Depression of hepatic glutathione by opioid analgesic drugs in mice.  Toxicol. Appl. Pharmacol. 99:139-147.

Skoulis NP, James RC, Harbison RD and Roberts SM. 1989. Perturbation of glutathione by a central action of morphine.  Toxicology. 57:287-302.

Clevenger MA, Roberts SM, Lattin DL, Harbison RD and James RC. 1989. The pharmacokinetics of 2,2’,5,5’-tetrachlorobiphenyl and 3,3’,4,4’-tetrachlorobiphenyl and its relationship to toxicity.  Toxicol. Appl. Pharmacol. 100:315-327.

Safe S, Mason G, Sawyer T, Zacharewski T, Harris MA, Yao C, Keys B, Farrell K, Holcomb M, Davis D, Safe L, Piskorska-Pliszcyzynska J, Leece B, Denomme M, Hutzinger O, Thoma H, Chittim B, and Madge J. 1989. Development and validation of in vitro induction assays for toxic halogenated aromatic mixtures: a review. Toxicol Ind Health. 5(5):757-775.

Safe S, Zacharewski T, Safe L, Harris MA, Yao C, and Holcomb M. 1989. Validation of the AHH induction bioassay for the determination of 2,3,7,8-TCDD toxic equivalents. Chemosphere. 18(1-6):941-946.

Zacharewski T, Harris MA, and Safe S. 1989. Induction of cytochrome P450-dependent monooxygenase activities in rat hepatoma H-4-IIE cells in culture by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds: mechanistic studies using radiolabeled congeners. Arch Biochem Biophys. 272(2):344-355.

Zacharewski T, Harris MA, Safe S, Thoma H, Hauschulz G, Knorr E, and Hutzinger O. 1989. Application of the in vitro AHH induction bioassay for determining 2,3,7,8-TCDD equivalents: pyrolyzed flame retardant mixtures. Chemosphere. 18(1-6):383-387.

Couture, L.A., M.W. Harris, and L.S. Birnbaum. Teratogenicity of 2,3,4,7,8-Pentachlorodibenzofuran (4-PeCDF) in F344 rats. Presented at the Society of Toxicology Annual Meeting. February 15-19, 1988. Dallas, TX.

Birnbaum LS and Couture LA. 1988. Disposition of Octachlorodibenzo-p-dioxin (OCDD) in male rats. Toxicol Appl Pharmacol. 93:22-30.

Harris, M., T. Zacharewski, B. Astroff, C. Kamps, and S. Safe. Characterization of 6-Methyl-1,3,8-Trichlorodibenz-furan (MCDF) as a 2,3,7,8-TCDD Antagonist in Male Rats: Induction of Monooxygenases. Dioxin ’88 Symposium. August 21-26, 1988. Umea, Sweden.

Couture LA, Elwell MR, and Birnbaum LS. 1988. Dioxin-like effects observed in male rats following exposure to Octachlorodibenzo-p-dioxin (OCDD) during a 13-week study. Toxicol Appl Pharmacol. 93:31-46.

Harris, M., C. Kamps, and S. Safe. Role of 4s binding protein in the induction of aryl hydrocarbon hydroxylase in the rat. Society of Toxicology 27th Annual Meeting. February 15-19, 1988. Dallas, TX

Harris MA, Kamps C, and Safe S. 1988. Role of the 4-5S binding protein in the induction of aryl hydrocarbon hydroxylase in the rat. Carcinogenesis. 9(8):1475-1479.

Zacharewski, T., M. Harris, and S. Safe. 1988. Validation of the in vitro bioassay: determination of 2,3,7,8-TCDD equivalents in pyrolyzed flame retardants and great lakes fish extracts. Gulf Coast Society of Toxicology and Southwest Environmental Mutagens Society Meeting. 1988. Houston, TX.

Smith AC, Roberts SM, Berman LM, Harbison RD and James RC. 1988. Effects of piperonyl butoxide on halothane hepatotoxicity and metabolism in the hyperthyroid rat.  Toxicology. 50: 95-105.

James RC, Wessinger WD, Roberts SM, Millner GC and Paule MG. 1988. Centrally mediated opioid induced depletion of hepatic glutathione: Effects of intracerebroventricular administration of mu, kappa, sigma and delta agonists.  Toxicology 51:267-279.

Smith AC, Roberts SM, James RC, Berman LM and Harbison RD. 1988. Comparison of covalent binding from halothane metabolism in hepatic microsomes from phenobarbital-induced and hyperthyroid rats.  Xenobiotica. 18: 991-1001.

Kerger BD, James RC and Roberts SM. 1988. An assay for phentolamine using high performance liquid chromatography with electrochemical detection.  Anal. Biochem. 170:145-151.

Kerger BD, Gandy J, Bucci TJ, Roberts SM, Harbison RD and James RC. 1988. Antagonism of bromobenzene-induced hepatotoxicity by the alpha-adrenergic blocking agents, phentolamine and idazoxan.  Toxicol. Appl. Pharmacol. 95: 12-23.

Kerger BD, Roberts SM, Hinson JA, Gandy J, Harbison RD and James RC.  1988. Antagonism of bromobenzene-induced hepatotoxicity by phentolamine:  Evidence for a metabolism independent intervention.  Toxicol.  Appl. Pharmacol. 95: 24-31.

Kerger BD, Robert SM and James RC.  1988. Comparison of human and mouse liver microsomal metabolism of bromobenzene and chlorobenzene to 2- and 4-halophenols.  Drug Metab. Dispos. 16:672-677.

Zacharewski T, Harris MA, Safe S, Thoma H, and Hutzinger O. 1988. Applications of the in vitro aryl hydrocarbon hydroxylase induction assay for determining “2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents”: pyrolyzed brominated flame retardants. Toxicology. 51:177-189.

Gandy, J., C.M. Teaf, F.A. Adatsi, R.C. James and R.D. Harbison. The dependence of male reproductive toxicity on germ cell stage. In: Functional Teratogenesis: Functional Effects on the Offspring after Parental Drug Exposure. T. Fujii and P.M. Adams (Eds.), Teikyo University Press, Tokyo, Japan. pp. 133-143,  1987.

Couture, L.A., and L.S. Birnbaum. Evaluation of Subchronic exposure to Octachlorodibenzodioxin (OCDD). Presented at the Society of Toxicology Annual Meeting. February 23-27, 1987. Washington, DC.

Robert SM, Grund VR, James RC and Harbison RD.  1987. Histamine and hepatic glutathione in the mouse.  Life Sci. 40:2103-2110.

Kamps, C., M. Harris, and S. Safe. 1987. Polynuclear aromatic hydrocarbon—4s binding protein interactions. Structure activity relationships. Society of Toxicology 26th Annual Meeting. February 1987. Washington DC.

James RC, Schiefer MA, Roberts SM and Harbison RD. 1987. Antagonism of cocaine-induced hepatotoxicity by the a-adrenergic antagonists phentolamine and yohimbine.  J. Pharmacol. Exp. Ther. 242:726-732.

Safe, S., T. Zacherewski, M. Harris, C. Yao, and M. Holcomb. 1987. Validation of the AHH induction bioassay for the determination of 2,3,7,8-TCDD toxic equivalents. Dioxin ’87 Symposium. October 4-9, 1987. Las Vegas, NV.

Roberts SM, Skoulis NP and James RC.  1987. A centrally mediated effect of morphine to diminish hepatocellular glutathione.  Biochem. Pharmacol. 36:3001-3005.

Zacharewski, T., M. Harris, S. Safe, H. Thoma, G. Hauschulz, E. Knorr, and O. Hutzinger. 1987. Applications of the In vitro AHH induction bioassay for determining 2,3,7,8-TCDD equivalents: pyrolyzed flame retardant mixtures. Dioxin ’87 Symposium. October 4-9, 1987. Las Vegas, NV.

Roberts SM, James RC, Simmons HF and Harbison RD. 1987. Alcohol and cocaine-induced liver injury.  Alcohol Health Res. World. 11:20-25.

Birnbaum, L.S., and L.A. Couture. 1986. Disposition of Octachlorodibenzo-p-dioxin (OCDD) in rats. Society of Toxicology Annual Meeting. March 3-7, 1986. New Orleans, LA. The Toxicologist. 6:310.

Goodman, D.R., R.C. James and R.D. Harbison.  Chemical-induced heritable cell changes:  Description of mutagenicity assays and applications of test results.  In:  Reproductive Toxicology.  R.L. Dixon (Ed.), Raven Press, New York, NY. pp. 267-285,  1985.

James, R.C.  General Principles of Toxicology.  In:  Industrial Toxicology:  Safety and Health Applications in the Workplace.  P. Williams and J. Burson (Eds.), Van Nostrand Reinhold Company, New York, NY. pp. 7-26,  1985.

James, R.C.  Hematotoxicity:  Toxic Effects in the Blood.   In:  Industrial Toxicology:  Safety and Health Applications in the Workplace.  P. Williams and J. Burson (Eds.), Van Nostrand Reinhold Company, New York, NY. pp. 59-77,  1985.

James, R.C.  Hepatotoxicity:  Toxic Effects in the Liver.  In:  Industrial Toxicology:  Safety and Health Applications in the Workplace.  P. Williams and J. Burson (Eds.), Van Nostrand Reinhold Company, New York, NY. pp. 78-105,  1985.

James, R.C.  Neurotoxicity:  Toxic Effects in the Nervous System.  In:  Industrial Toxicology:  Safety and Health Applications in the Workplace.  P. Williams and J. Burson (Eds.), Van Nostrand Reinhold Company, New York, NY. pp.123-137,  1985.

James, R.C.  Effects of Organic Solvents.   In:  Industrial Toxicology:  Safety and Health Applications in the Workplace.  P. Williams and J. Burson (Eds.), Van Nostrand Reinhold Company, New York, NY. pp. 230-259,  1985.

James, R.C.  Risk Assessment.   In:  Industrial Toxicology:  Safety and Health Applications in the Workplace.  P. Williams and J. Burson (Eds.), Van Nostrand Reinhold Company, New York, NY. pp. 369-398,  1985.

James, R.C. and C.M. Teaf.  Carcinogenesis.  In:  Industrial Toxicology:  Safety and Health Applications in the Workplace.  P. Williams and J. Burson (Eds.), Van Nostrand Reinhold Company, New York, NY. pp. 301-342,  1985.

James RC, Freeman RW and Harbison RD. 1984. L-alpha-acetylmethadol- induced tissue alterations in mice.  Drug Chem. Toxicol. 7:91-112.

Smith AC, James RC, Berman LM and Harbison RD. 1984. Paradoxical effects of perturbation of intracellular levels of glutathione on halothane-induced hepatotoxicity in hyperthryoid rats.  Fundam. Appl. Toxicol. 4:221-230.

James RC, Roberts SM and Harbison RD. 1983. The perturbation of hepatic glutathione by alpha-2 adrenergic agonists.  Fundam. Appl. Toxicol. 3:303-308.

Smith A, Berman LM, James RC and Harbison RD. 1983. Characterization of hyperthyroidism enhancement of halothane-induced hepatotoxicity.  Biochem. Pharmacol. 32:3531-3539.

James RC and Harbison RD. 1982. Hepatic glutathione and hepatotoxicity:  Effects of cytochrome P-450 complexing compounds SKF525-A, L-alpha acetamethadol (LAAM), norLAAM, and piperonyl butoxide.  Biochem. Pharmacol. 31:1829-1835.

James RC, Goodman DR and Harbison RD. 1982. Hepatic glutathione and hepatotoxicity:  Changes induced by selected narcotics.  J. Pharmacol. Exp. Ther. 221:708-714.

Goodman DR, James RC and Harbison RD. 1982. Placental Toxicology.  Food. Chem. Toxicol. 20:123-128,  1982.

Kupfer A, James RC, Carr K and Branch R. 1982. Analysis of hydroxylated and demethylated metabolites of mephenytoin in man and laboratory animals using gas-liquid chromatography and high-performance liquid chromatography.  J. Chromatogr. 232:93-100.

Desmond PV, James RC, Schenker S and Branch RA. 1981. Preservation of glucuronidation in carbon tetrachloride-induced acute liver injury in the rat.  Biochem. Pharmacol. 30:993-999.

James RC, Villenevue JP, Kupfer AH and Branck RA. 1981. Induction of drug-metabolizing enzymes by the enantionmers of normephenytoin in the rat.  Drug Metab Dispos 9:297-302.

James RC, Desmond PV, Kupfer A, Schenker S and Branch RA. 1981. The differential localization of various drug metabolizing systems within the rat liver lobule as determined by the hepatotoxins allyl alcohol, carbon tetrachloride and bromobenzene.  J. Pharmacol. Exp. Ther. 217:127-132.

Verbeeck R, James RC, Taber DF, Sweetman B and Wilkinson GR. 1980. The determination of meperdine, normeperidine and deuterated analogs in blood and plasma by gas chromatography mass spectrometry selected ion monitoring.  Biomed. Mass Spectrom. 7:58-60.

James RC and Franklin MR.  The triphasic amphetamine lethal dose curve in mice and its possible relationship to drug metabolism.  Toxicol. Appl. Pharmacol. 44:63-73.

James RC and Franklin MR. 1978. Tissue concentrations and the mortality of d-amphetamine in mice:  Change associated with the use of diethaminoethyl 2,2. diphenylvalerate. HCI.  Toxicol. Appl. Pharmacol. 44:75-80.

James RC and Franklin MR. 1975. Comparisons of the formation of cytochrome P-450 complexes absorbing at 455 n.m. in rabbit and rat microsomes.  Biochem. Pharmacol. 24:835-838.