Banerjee A, Kar S, Roy K, Patlewicz G , Charest N, Benfenati E, Cronin MTD. 2024. Molecular similarity in chemical informatics and predictive toxicity modeling: From quantitative read-across (q-RA) to quantitative read-across structure-activity relationship (q-RASAR) with the application of machine learning. Crit Rev Toxicol 54(9):659-684; doi: 10.1080/10408444.2024.2386260 . PMID: 39225123.
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Publication: Manuscripts
/ Topics: modeling
Hagan B, Patlewicz G , Shah I. Metabolic similarity in read-across prediction: A case study using graph convolutional networks to predict genotoxicity outcomes from metabolic networks. Abstract 62, American Society for Cellular and Computation Toxicology 13th Annual Meeting, Research Triangle Park, NC, October 2024.
Publication: Abstracts and Presentations
/ Topics: computational toxicology , read-across
Leary AJ, Patlewicz G , Shah I. An exploration of the use of hybrid fingerprints in generalized read-across and their impact on predictive performance for selected in vivo toxicity outcomes. Abstract 42, American Society for Cellular and Computation Toxicology 13th Annual Meeting, Research Triangle Park, NC, October 2024.
Publication: Abstracts and Presentations
/ Topics: computational toxicology , read-across
Rogers JD, Patlewicz G , Baker E, Bettmann A, Clippinger A, Paul Friedman K. High-throughput safety pharmacology screening to better understand data-poor chemicals. Abstract 57, American Society for Cellular and Computation Toxicology 13th Annual Meeting, Research Triangle Park, NC, October 2024.
Publication: Abstracts and Presentations
/ Topics: pharmacology
Perry CS , Verwiel AH, Covington TR, Proctor DM. 2024. PBPK modeling demonstrates that exposure time adjustment is unnecessary for setting an acute manganese inhalation exposure guideline. Regul Toxicol Pharmacol 153(Nov):105698; doi: 10.1016/j.yrtph.2024.105698 . PMID: 39251127.
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Publication: Manuscripts
/ Topics: Air Quality , Manganese , modeling , PBPK/PBDE
Patlewicz G , Judson RS, Williams AJ, Butler T, Barone Jr. S, Carstens K, Cowden J, Dawson JD, et al. 2024. Development of chemical categories for per- and polyfluoroalkyl substances (PFAS) and the proof-of-concept approach to the identification of potential candidates for tiered toxicological testing and human health assessment. Comput Toxicol 131(Sep 1):100327; doi: 10.1016/j.comtox.2024.100327 . PMID: 40547594.
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Publication: Manuscripts
/ Topics: PFAS
Jackson JW, Frederick C Streich Jr, Pal A, Coricor G, Boston C, …, Wood M , et al. 2024. An antibody that inhibits TGF-β1 release from latent extracellular matrix complexes attenuates the progression of renal fibrosis. Sci Signal 17(844): DOI: 10.1126/scisignal.adn6052.
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Publication: Manuscripts
/ Topics: Toxicology
Thompson CM , Dewhurst N, Moundous D, Borghoff SJ , Haws LC, Vasquez MZ. 2024. Assessment of the genotoxicity of tert-butyl alcohol in an in vivo thyroid comet assay. Environ Mol Mutagen 65(3–4):129–136; doi: 10.1002/em.22601 . PMID: 38717101.
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Publication: Manuscripts
/ Topics: Toxicology
Mathisen GH, Bearth A, Jones LB, Hoffmann S, Vist GE, Ames HM,… Wikoff D , Wright F, Whaley P. 2024. Editorial: Time for CHANGE: System-level interventions for bringing forward the date of effective use of NAMs in regulatory toxicology. Arch Toxicol 98(8):2299-2308; doi: 10.1007/s00204-024-03802-6 . PMID: 38877155.
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