Wikoff D , Haws L, Ring C, Budinsky R. 2019. Application of qualitative and quantitative uncertainty assessment tools in developing ranges of plausible toxicity values for 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin. J Appl Toxicol 39(9):1293-1310; doi: 10.1002/jat.3814 . PMID: 31257608.
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Publication: Manuscripts
/ Topics: dioxin , risk assessment
Thompson CM , Fitch SE , Ring C, Rish W, Cullen JM, Haws LC. 2019. Development of an oral reference dose for the perfluorinated compound GenX. J Appl Toxicol 39(9):1267–1282; doi: 10.1002/jat.3812 .
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Publication: Manuscripts
/ Topics: benchmark dose estimation (BMD) , PFAS , water
Webster F, Gagne M, Patlewicz G , Pradeep P, Trefiak N, Judson R, Barton-Maclaren TS. 2019. Predicting estrogen receptor activation by a group of substituted phenols: An integrated approach to testing and assessment case study. Regul Toxicol Pharmacol 106(Aug):278-291; doi: 10.1016/j.yrtph.2019.05.017 . PMID: 31121201.
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Publication: Manuscripts
/ Topics: NAMs
Patlewicz G , Lizarraga L, Rua D, Allen DG, Daniel A, Fitzpatrick SC, Garcia-Reyero N, Gordon J, et al. 2019. Exploring current read-across applications and needs among selected US federal agencies. Regul Toxicol Pharmacol 106(Aug):197-209; doi: 10.1016/j.yrtph.2019.05.011 . PMID: 31078681.
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Publication: Manuscripts
/ Topics: NAMs
Fitch S , van de Ligt J, Payne L, Doepker C, Kleinman R, Handu D, Cohen SM, Anyangwe N, Wikoff D . 2019. Systematic map protocol: A systematic map of the use of acceptable daily intake (ADI) as a health-based benchmark in nutrition research studies that consider the safety of low-calorie sweeteners (LCS). Open Science Framework .
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Publication: Protocol Registrations
/ Topics: nutrition , Systematic Review
Sheridan E, Moose J, Liu Y, Martini C, Lea I , Fostel J. NTP high-level summary data collections in the Chemical Effects in Biological Systems (CEBS) database. Poster PS01-0606. Presented at 15th International Congress of Toxicology, Honolulu, HI, July 2019.
Publication: Abstracts and Presentations
/ Topics: computational toxicology , data literacy
Olack E, Heintz MM , Baldwin WS. Human CYP2B6 is an anti-obesity enzyme involved in unsaturated fatty acid metabolism. International Congress on Toxicology (ICTXV), Honolulu, HI, July 2019.
Publication: Abstracts and Presentations
/ Topics: metabolites
Klaren WD , Ring C, Harris MA, Thompson CM , Borghoff S , Sipes NS, Hsieh JH, Auerbach SS, Rager JE. 2019. Identifying attributes that influence in vitro-to-in vivo concordance by comparing Tox21 bioactivity versus DrugMatrix transcriptomic responses across 130 chemicals. Toxicol Sci 167(1):157–171; doi: 10.1093/toxsci/kfy220 . PMID: 30202884.
View Abstract
Publication: Manuscripts
/ Topics: transcriptomics
Bhawana B, Lea I , Liu Y, Martini C, Fostel J. Access to National Toxicology Program histopathology lesion collection in Chemical Effects in Biological Systems (CEBS) database. Poster P040. Presented at the 38th Annual Symposium of Society for Toxicologic Pathology, Raleigh, NC, June 2019.
Publication: Abstracts and Presentations
/ Topics: computational toxicology
Urban J , Wikoff D , Haws L. Three-tiered approach to integrating evidence streams assessing gestational trichloroethylene exposure and congenital heart defects (TCE-CHD). Poster at Evidence Integration in Chemical Assessments: Challenges Faced in Developing and Communicating Human Health Effect Conclusions, National Academies of Sciences, Engineering, and Medicine, Washington, DC, June 2019.