2024
Firman JW, Boobis A, Hollnagel HM, Kaiser S, Lovell DP, Moretto A, Muller S,…, Patlewicz G . 2024. Evaluating the consistency of judgements derived through both in silico and expert application of the Cramer classification scheme. Food Chem Toxicol 194(Dec):115070; doi: 10.1016/j.fct.2024.115070 . PMID: 39447833.
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Topics: risk assessment
Mattes RD, Rivera BN, Rutigliani GR, Rogers S, Mendoza ID, Wang L, Beckemeier K, Wikoff D . 2024. A review of low- and no-calorie sweetener safety and weight management efficacy. Nutrition Today 59(6):261-288; doi: 10.1097/NT.0000000000000723 .
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Topics: Food science , nutrition , risk assessment
Banerjee A, Kar S, Roy K, Patlewicz G , Charest N, Benfenati E, Cronin MTD. 2024. Molecular similarity in chemical informatics and predictive toxicity modeling: From quantitative read-across (q-RA) to quantitative read-across structure-activity relationship (q-RASAR) with the application of machine learning. Crit Rev Toxicol 54(9):659-684; doi: 10.1080/10408444.2024.2386260 . PMID: 39225123.
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Topics: modeling
Perry CS , Verwiel AH, Covington TR, Proctor DM. 2024. PBPK modeling demonstrates that exposure time adjustment is unnecessary for setting an acute manganese inhalation exposure guideline. Regul Toxicol Pharmacol 153(Nov):105698; doi: 10.1016/j.yrtph.2024.105698 . PMID: 39251127.
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Topics: Air Quality , Manganese , modeling , PBPK/PBDE
Patlewicz G , Judson RS, Williams AJ, Butler T, Barone Jr. S, Carstens K, Cowden J, Dawson JD, et al. 2024. Development of chemical categories for per- and polyfluoroalkyl substances (PFAS) and the proof-of-concept approach to the identification of potential candidates for tiered toxicological testing and human health assessment. Comput Toxicol 131(Sep 1):100327; doi: 10.1016/j.comtox.2024.100327 . PMID: 40547594.
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Topics: PFAS
Jackson JW, Frederick C Streich Jr, Pal A, Coricor G, Boston C, …, Wood M , et al. 2024. An antibody that inhibits TGF-β1 release from latent extracellular matrix complexes attenuates the progression of renal fibrosis. Sci Signal 17(844):eadn6052; doi: 10.1126/scisignal.adn6052 . PMID: 38980922.
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Topics: drug development
Thompson CM , Dewhurst N, Moundous D, Borghoff SJ , Haws LC, Vasquez MZ. 2024. Assessment of the genotoxicity of tert-butyl alcohol in an in vivo thyroid comet assay. Environ Mol Mutagen 65(3–4):129–136; doi: 10.1002/em.22601 . PMID: 38717101.
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Topics: genotoxicity
Mathisen GH, Bearth A, Jones LB, Hoffmann S, Vist GE, Ames HM,… Wikoff D , Wright F, Whaley P. 2024. Editorial: Time for CHANGE: System-level interventions for bringing forward the date of effective use of NAMs in regulatory toxicology. Arch Toxicol 98(8):2299-2308; doi: 10.1007/s00204-024-03802-6 . PMID: 38877155.
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Topics: regulatory toxicology
Patlewicz G , Karamertzanis P, Paul-Friedman K, Sannicola M, Shah I. 2024. A systematic analysis of read-across within REACH registration dossiers. Comput Toxicol 30(June):100304; doi: 10.1016/j.comtox.2024.100304 . PMID: 38993812.
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Topics: read-across , regulatory toxicology
Wharton GT, Becker C, Bennett D, Burcu M, Bushnell G, Ferrajolo C,… Movva N,…, Suh M , et al. 2024. Overview of global real-world data sources for pediatric pharmacoepidemiologic research. Pharmacoepidemiol Drug Saf 33(1):e5695; doi: 10.1002/pds.5695 . PMID: 37690792.
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