Publication Topic

Wikoff DS, Rager JE, Haws LC, Borghoff SJ. 2016. A high dose mode of action for tetrabromobisphenol A-induced uterine adenocarcinomas in Wistar Han rats: A critical evaluation of key events in an adverse outcome pathway framework. Regul Toxicol Pharmacol 77(June):143-159. doi: 10.1016/j.yrtph.2016.01.018. PMID: 26828025.

Wikoff D, Borghoff SJ, Rager JE, Haws LC. Human relevance assessment of tetrabromobisphenol-A (TBBPA) induced uterine adenocarcinomas: Mode of action dependent on high dose molecular initiating event (MIE). Presented in the “Flame Retardants” session at Society of Toxicology 55th Annual Meeting, New Orleans, LA, March 2016.

Borghoff SJ, Wikoff D, Rager JE, Haws LC. Tetrabromobisphenol A (TBBPA); Dose- and time-dependent changes in plasma TBBPA and its conjugates over 28 days of administration. Presented at Society of Toxicology 55th Annual Meeting, New Orleans, LA, March 2016.

Borghoff SJ, Wikoff D, Harvey S, Haws L. 2016. Dose- and time-dependent changes in tissue levels of tetrabromobisphenol A (TBBPA) and its sulfate and glucuronide conjugates following repeated administration to female Wistar Han Rats. Toxicol Rep 3:190-201. doi: 10.1016/j.toxrep.2016.01.007.

Wikoff D, White MC, Borghoff SJ, Haws LC. Evaluation of tetrabromobisphenol A (TBBPA)-induced endocrine-related target gene activity using high-throughput screening data from ToxCast. Presented at Society of Toxicology 54th Annual Meeting, San Diego, CA, March 2015.

Borghoff SJ, Wikoff D, White MC, Thompson C, Haws LC. Identification of the molecular initiating event (MIE) for TBBPA induced uterine tumors in the framework of an adverse outcome pathway (AOP). Presented at Society of Toxicology 54th Annual Meeting, San Diego, CA, March 2015.

Wikoff D, Thompson C, Perry C, White M, Borghoff S, Fitzgerald L, Haws LC. 2014. Development of toxicity values and exposure estimates for tetrabromobisphenol A [TBBPA]: Application in a margin of exposure assessment. J Appl Toxicol 35(11):1292-1308; doi: 10.1002/jat.3132.

Haws LC, Thompson C, Perry C, White M, Fitzgerald L, Borghoff S, Wikoff D. Development of non-cancer based toxicity factors and daily dose estimates for TBBPA. Presented at Society of Toxicology 53rd Annual Meeting, Phoenix, AZ, March 2014.

Wikoff D, Thompson C, Perry C, White M, Fitzgerald L, Borghoff S, Haws LC. Development of an oral cancer slope factor and lifetime average daily dose estimates for TBBPA. Presented at Society of Toxicology 53rd Annual Meeting, Phoenix, AZ, March 2014.

Staskal DF, Birnbaum LS. 2011. Health effects of brominated flame retardants. In: The Handbook of Environmental Chemistry, vol. 16 — Brominated Flame Retardants. Springer.