2022
LaPlaca SB, Heintz MM, Wikoff D , Haws LC. Multi-step integration of ecotoxicological study reliability in ecological risk assessment. Poster at Society of Environmental Toxicology and Chemistry SETAC North America 43rd Annual Meeting, Philadelphia, PA, November 2022.
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Publication: Abstracts and Presentations
/ Topics: ecotoxicology , risk assessment
Patlewicz G , Richard AM, Williams AJ, Judson RS, Thomas RS. 2022. Towards reproducible structure-based chemical categories for PFAS to inform and evaluate toxicity and toxicokinetic testing. Comput Toxicol 24(Nov):100250; doi: 10.1016/j.comtox.2022.100250 . PMID: 36969381.
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Publication: Manuscripts
/ Topics: NAMs , PFAS
Heintz MM , Chappell GA, Thompson CM , Haws LC. 2022. Evaluation of transcriptomic responses in livers of mice exposed to the short-chain PFAS compound HFPO-DA. Front Toxicol 4(Jun 27):937168; doi: 10.3389/ftox.2022.937168 . PMID: 35832492.
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Publication: Manuscripts
/ Topics: PFAS , transcriptomics
Goyak KO, Sarang SS, Franzen A , Borghoff SJ , Ryman-Rasumssen JP. 2022. Adverse outcome pathway (AOP): α2u-globulin nephropathy and kidney tumors in male rats. Crit Rev Toxicol 52(5):345-357; doi: 10.1080/10408444.2022.2082269 . PMID: 35862579.
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Publication: Manuscripts
/ Topics: Adverse outcome pathways (AOPs)
Foster MJ, Patlewicz G , Shah I, Haggard DE, Judson RS, Paul Friedman K. 2022. Evaluating structure-based activity in a high throughput assay for steroid biosynthesis. Comput Toxicol 24(Nov):100245; doi: 10.1016/j.comtox.2022.100245 . PMID: 37841081.
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Publication: Manuscripts
/ Topics: NAMs
Suh M , Cloud M, Balasubramanian A, Movva N, Fryzek J, Cohen S. 2022. A systematic literature review (SLR) of MTAP deletions in multiple solid and hematologic cancers. PROSPERO 2022 CRD42022354037 .
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Publication: Protocol Registrations
/ Topics: Cancer , Epidemiology , Systematic Review
Patlewicz G , Richard A, Williams A, Judson R, Thomas R. Towards reproducible structure-based chemical categories for PFAS to inform and evaluate toxicity and toxicokinetic testing. American Society for Cellular and Computation Toxicology 11th Annual Meeting, Chapel Hill, NC, October 2022.
Publication: Abstracts and Presentations
/ Topics: PFAS
Patlewicz G , Shah I. Towards systematic read-across using Generalised Read-Across (GenRA). American Society for Cellular and Computation Toxicology 11th Annual Meeting, Chapel Hill, NC, October 2022.
Publication: Abstracts and Presentations
/ Topics: read-across
Nicolas CI, Linakis MW, Minto MS, Mansouri K, Clewell RA, Yoon M, Wambaugh JF, Patlewicz G , et al. 2022. Estimating provisional margins of exposure for data poor chemicals using high throughput computational methods. Front Pharmacol 13(Oct 7):980747; doi: 10.3389/fphar.2022.980747 . PMID: 36278238.
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Publication: Manuscripts
/ Topics: computational toxicology
Carstens K, Carpenter A, FreudenrichT, Wallace K, Choo S, Patlewicz G , et al. Evaluation of per- and poly fluoroalkyl substances (PFAS) in vitro toxicity testing for developmental neurotoxicity. American Society for Cellular and Computation Toxicology 11th Annual Meeting, Chapel Hill, NC, October 2022.