2017
Kirman CR, Suh M, Proctor DM , Hays SM. 2017. Improved physiologically based pharmacokinetic model for oral exposures to chromium in mice, rats, and humans to address temporal variation and sensitive populations. Toxicol Appl Pharmacol 325(15 June):9-17; doi: 10.1016/j.taap.2017.03.023 28389273.
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Topics: chromium , modeling , PBPK/PBDE , pharmacokinetics
Judson RS, Martin M, Patlewicz G , Wood CE. 2017. Retrospective mining of toxicology data to discover multispecies and chemical class effects: Anemia as a case study. Regul Toxicol Pharmacol 86(June):74-92; doi: 10.1016/j.yrtph.2017.02.015 . PMID: 28242142.
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Topics: modeling
Mease K, Kimzey A , Lansita J. 2017. Biomarkers for nonclinical infusion reactions in marketed biotherapeutics and considerations for study design. Curr Opin Toxicol 4(June):1–15; doi: 10.1016/j.cotox.2017.03.005 . PMID: 29658009.
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Topics: biomarkers
Borghoff SJ , Ring C, Banton M, Leavens TL. 2017. Physiologically based pharmacokinetic model for ethyl tertiary-butyl ether and tertiary-butyl alcohol in rats: Contribution of binding to a2u-globulin in male rats and high-exposure nonlinear kinetics to toxicity and cancer outcomes. J Appl Toxicol 37(5):621-640; doi: 10.1002/jat.3412 . PMID: 27885692.
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Topics: modeling , pharmacokinetics
Greene T, Rogers S, Franzen A , Gentry R. 2017. A critical review of the literature to conduct a toxicity assessment for oral exposure to methyl salicylate. Crit Rev Toxicol 47(2):98–120; doi: 10.1080/10408444.2016.1236071 . PMID: 27834107.
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Topics: benchmark dose estimation (BMD) , Exposure Assessment , food additives , mode of action
Fitzpatrick J, Patlewicz G . 2017. Application of IATA – A case study in evaluating the global and local performance of a Bayesian network model for skin sensitization. SAR QSAR Environ Res 28(4):297-310; doi: 10.1080/1062936X.2017.1311941 . PMID: 28423913.
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Topics: Adverse outcome pathways (AOPs) , Bayesian modeling
Fitzpatrick JM, Roberts DW, Patlewicz G . 2017. What determines skin sensitization potency–Myths, maybes and realities. The 500 molecular weight cut-off – An updated analysis. J Appl Toxicol 37(1):105-116; doi: 10.1002/jat.3348 . PMID: 27283458.
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Topics: Exposure Assessment
Fitzpatrick JM, Roberts DW, Patlewicz G . 2017. Is skin penetration a determining factor in skin sensitization potential and potency? Refuting the notion of a LogKow threshold for skin sensitization. J Appl Toxicol 37(1):117-127; doi: 10.1002/jat.3354 . PMID: 27357739.
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Topics: Exposure Assessment
Lea IA , Gong H, Paleja A, Rashid, A, Foster J. 2017. CEBS: A comprehensive annotated database of toxicological data. Nucleic Acids Res 45(D1):D964–D971; doi: 10.1093/nar/gkw1077 . PMID: 27899660.
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Topics: computational toxicology
2016
Thompson CM , Bichteler A, Rager JE, Suh M , Proctor DM, Haws LC, Harris MA. 2016. Comparison of in vivo genotoxic and carcinogenic potency to augment mode of action analysis: Case study with hexavalent chromium. Mut Res/Genet Toxicol Environ Mutagen 800-801(April):28-34; doi: 10.1016/j.mrgentox.2016.01.008 .
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