2018
Patlewicz G , Cronin MTD, Helman G, Lambert JC, Lizarraga LE, Shah I. 2018. Navigating through the minefield of read-across frameworks: A commentary perspective. Comput Toxicol 6(May):39-54; doi: 10.1016/j.comtox.2018.04.002 .
View Abstract
Topics: computational toxicology , NAMs
Thompson CT , Suh M , Chappell G, Borghoff S , Ellis-Hutchings, R, Wiench, K, Finch, L, Proctor DM. 2018. Assessment of the mode of action underlying development of forestomach tumors in rodents following oral exposure to ethyl acrylate and relevance to humans. Regul Toxicol Pharmacol 96:178–189; doi: 10.1016/j.yrtph.2018.05.006 .
View Abstract
Topics: carcinogens , mode of action , risk assessment
Suh M , Proctor DM , Chappell G, Rager JE, Thompson CM , Borghoff S , Finch L, Ellis-Hutchings R, Wiench K. 2018. A review of the genotoxic, mutagenic, and carcinogenic potentials of several lower acrylates. Toxicol 402-403(June 1):50-67; doi: 10.1016/j.tox.2018.04.006 .
View Abstract
Topics: carcinogens , chemical safety assessment , consumer products
Proctor DM , Suh M , Chappell G, Borghoff SJ , Thompson CM , Wiench K, Finch L, Ellis-Hutchings R. 2018. An adverse outcome pathway (AOP) for forestomach tumors induced by non-genotoxic initiating events. Regul Toxicol Pharmacol, 96(July):30-40; doi: 10.1016/j.yrtph.2018.04.016 .
View Abstract
Topics: Adverse outcome pathways (AOPs) , Cancer , genotoxicity
Clippinger A, Allen D, Jarabek AM, Corvaro M, Gaça M, Gehen S, Hotchkiss JA, Patlewicz G , et al. 2018. Alternative approaches for acute inhalation toxicity testing to address global regulatory and non-regulatory data requirements: An international workshop report. Toxicol In Vitro 48(April):53-70; doi: 10.1016/j.tiv.2017.12.011 . PMID: 29277654.
View Abstract
Topics: NAMs
Thompson CM , Kirman CR, Hays SM, Suh M , Harvey SE , Proctor DM, Rager JE, Haws LC, Harris MA. 2018. Integration of mechanistic and pharmacokinetic information to derive oral reference dose and margin-of-exposure values for hexavalent chromium. J Appl Toxicol 38:351–365. doi: 10.1002/jat.3545 .
View Abstract
Topics: chromium , pharmacokinetics
Wikoff D (contributing author), EFSA (European Food Safety Authority), EBTC (Evidence-Based Toxicology Collaboration). 2018. EFSA Scientific Colloquium 23. Evidence integration in risk assessment: The science of combining apples and oranges. EFSA Supporting Publication 2018:15(3):1396; doi: 10.2903/sp.efsa.2018.EN-1396 .
View Abstract
Topics: evidence synthesis , risk assessment
Wikoff D , Urban JD , Harvey S , Haws LC. 2018. Role of risk of bias in systematic review for chemical risk assessment: A case study in understanding the relationship between congenital heart defects and exposures to trichloroethylene. Int J Toxicol 37(2):125-143; doi: 10.1177/1091581818754330.
View Abstract
Topics: risk assessment , Systematic Review , trichloroethylene
Roberts DW, Patlewicz G . 2018. Non-animal assessment of skin sensitization hazard – Is an integrated testing strategy needed, and if so what should be integrated? J Appl Toxicol 38(1):41-50; doi: 10.1002/jat.3479 . PMID: 28543848.
View Abstract
Topics: Adverse outcome pathways (AOPs) , modeling
Doepker C, Franke K, Myers E, Goldberger JJ, Lieberman HR, O’Brien C, Peck J, Tenenbein M, Weaver C, Wikoff D . 2018. Key findings and implications of a recent systematic review of the potential adverse effects of caffeine consumption in healthy adults, pregnant women, adolescents, and children. Nutrients 10(10):1536; doi: 10.3390/nu10101536 .
View Abstract