2021
Gentry R, Greene T, Chappell G, Lea I , Borghoff S , Yang C, Rathman J, Ribeiro JV, Hobocienski B, Mostrag A, Rodricks J, Clewell H. 2021. Integration of evidence to evaluate the potential for neurobehavioral effects following exposure to USFDA-approved food colors. Food Chem Toxicol 151:112097. doi: 10.1016/j.fct.2021.112097. Epub 2021 Mar 4. PMID: 33677041.
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Publication: Manuscripts
Lea IA , Chappell GA, Wikoff DS . 2021. Overall lack of genotoxic activity among five common low- and no-calorie sweeteners: A contemporary review of the collective evidence. Mutat Res Genet Toxicol Environ Mutagen 868–869:503389. doi: 10.1016/j.mrgentox.2021.503389. PMID: 34454695.
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Publication: Manuscripts
Wikoff D, Fitch S, Borghoff S. Case-study applications using evidence-based approaches to assess endocrine activity for risk assessment. Invited speaker (Wikoff): 61st Annual Meeting (virtual) of the Society for Birth Defects Research & Prevention, June 2021.
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Publication: Abstracts and Presentations
Wikoff D. The [acceptable daily intake] for low- and no-calorie sweeteners: Origin, interpretation, and application. Invited speaker: Continuing education webinar, Institute for the Advancement of Food and Nutrition Sciences, July 2021.
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Publication: Abstracts and Presentations
Fitch SE , Payne LE, van de Ligt JLG, Doepker C , Handu D, Cohen SM, Anyangwe N, Wikoff D . 2021. Use of acceptable daily intake (ADI) as a health-based benchmark in nutrition research studies that consider the safety of low-calorie sweeteners (LCS): A systematic map. BMC Public Health 21(1):956, doi: 10.1186/s12889-021-10934-2.
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Publication: Manuscripts
Borghoff SJ , Fitch SE , Black MVB, McMullen PD, Andersen ME, Chappell GA. 2021. A systematic approach to evaluate plausible modes of [action] for mouse lung tumors in mice exposed to 4-methylimidozole. Regul Toxicol Pharmacol 124:104977; DOI: 10.1016/j.yrtph.2021.104977.
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Publication: Manuscripts
Proctor DM , Bhat V, Suh M , Reichert H , Jiang X , Thompson CM . 2021. Inhalation cancer risk assessment for environmental exposure to hexavalent chromium: Comparison of margin-of-exposure and linear extrapolation approaches. Regul Toxicol Pharmacol 124:104969, doi.org/10.1016/j.yrtph.2021.104969.
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Publication: Manuscripts
Ring C, Sipes NS, Hsieh JH, Carberry C, Koval LE, Klaren WD , Harris MA, Auerbach SS, Rager JE. 2021. Predictive modeling of biological responses in the rat liver using in vitro Tox21 bioactivity: Benefits from high throughput toxicokinetics. Comput Toxicol 18:100166; doi: 10.1016/j.comtox.2021.100166 . PMID: 34013136.
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Publication: Manuscripts
Dirven H, Vist GE, Bandhakavi S, Mehta J, Fitch SE , Pound P, Ram R, Kincaid B, Leenaars CHC, Chen M, Wright RA, Tsaioun K. 2021. Performance of preclinical models in predicting drug-induced liver injury in humans: A systematic review. Nature, Scientific Reports; open access .
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Publication: Manuscripts
Chappell GA, Heintz MM, Borghoff SJ, Doepker CL, Wikoff DS . 2021. Lack of potential carcinogenicity for steviol glycosides — Systematic evaluation and integration of mechanistic data into the totality of evidence. Food Chem Toxicol 150:112045.
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