2015
Petkov P, Patlewicz G , Schultz TW, Honma M, Todorov M, Kotov S, Dimitrov SD, Donner EM, Mekenyan OM. 2015. A feasibility study: Can information collected to classify for mutagenicity be informative in predicting carcinogenicity? Regul Toxicol Pharmacol 72(1):17-25; doi: 10.1016/j.yrtph.2015.03.003 . PMID: 25792138.
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Topics: Adverse outcome pathways (AOPs) , carcinogens
Patlewicz G , Ball N, Boogaard P, Becker RA, Hubesch B. 2015. Building scientific confidence in the development and evaluation of read-across. Regul Toxicol Pharmacol 72(1):117-133; doi: 10.1016/j.yrtph.2015.03.015 . PMID: 25857293.
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Topics: Adverse outcome pathways (AOPs) , read-across
Young RR, Thompson CM , Dinesdurage HR, Elbekai RH, Suh M , Rohr AC, Proctor DM. 2015. A robust method for assessing chemically induced mutagenic effects in the oral cavity of transgenic Big Blue® rats. Environ Mol Mutagen 56:629-636.
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Topics: Chrome VI , Cr(VI) MOA Study , Hexavalent Chromium
Borghoff SJ , Poet TS, Green S, Davis J, Hughes B, Mensing T, Sarang SS, Lynch AM, Hard GC. 2015. Methyl isobutyl ketone exposure-related increases in specific measures of α2u-globulin (α2u) nephropathy in male rats along with in vitro evidence of reversible protein binding. Toxicology 333(2015):1-13.
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Urban JD , Carakostas MC, Taylor SL. 2015. Steviol glycoside safety: Are highly purified steviol glycoside sweeteners food allergens? Food Chem Toxicol 75: 71-78.
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Thompson CM , Seiter J, Chappell MA, Tappero RV, Proctor DM, Suh M , Wolf JC, Haws LC, Vitale R, Mittal L , Kirman CR, Hays SM, Harris MA. 2015. Synchrotron-based imaging of chromium and γ-H2AX immunostaining in the duodenum following repeated exposure to Cr(VI) in drinking water. Toxicol Sci 143(1):16-25.
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Topics: Chrome VI , Cr(VI) MOA Study , Hexavalent Chromium
Patlewicz G , Simon T, Rowlands JC, Budinsky R, Becker RA. 2015. Proposing a scientific confidence framework to help support the application of adverse outcome pathways for regulatory purposes. Regul Toxicol Pharmacol 71(3):463-477; doi: 10.1016/j.yrtph.2015.02.011 . PMID: 25707856. (Top 10 Paper for RASS Award at SOT 2016 )
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Topics: Adverse outcome pathways (AOPs) , mode of action
Becker RA, Paul KB, Simon TW, Marty S, Patlewicz G , Rowland JC. 2015. An exposure:activity profiling method for interpreting high-throughput screening data for estrogenic activity—Proof of concept. Regul Toxicol Pharmacol 71(3):398-408; doi: 10.1016/j.yrtph.2015.01.008 . PMID: 25656492.
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Topics: Exposure Assessment
2014
Wikoff D, Thompson C, Perry C, White M, Borghoff S, Fitzgerald L, Haws LC. 2014. Development of toxicity values and exposure estimates for tetrabromobisphenol A [TBBPA]: Application in a margin of exposure assessment. J Appl Toxicol 35(11):1292-1308; doi: 10.1002/jat.3132 .
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Topics: flame retardants
Proctor DM, Suh M , Campleman SL, Thompson CM . 2014. Assessment of the mode of action for hexavalent chromium-induced lung cancer following inhalation exposures. Toxicology 325:160-179.
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