2021
Ring C, Sipes NS, Hsieh JH, Carberry C, Koval LE, Klaren WD , Harris MA , Auerbach SS, Rager JE. 2021. Predictive modeling of biological responses in the rat liver using in vitro Tox21 bioactivity: Benefits from high throughput toxicokinetics. Comput Toxicol 18:100166 , PMID: 34013136.
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Publication: Manuscripts
Dirven H, Vist GE, Bandhakavi S, Mehta J, Fitch SE , Pound P, Ram R, Kincaid B, Leenaars CHC, Chen M, Wright RA, Tsaioun K. 2021. Performance of preclinical models in predicting drug-induced liver injury in humans: A systematic review. Nature, Scientific Reports; open access .
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Publication: Manuscripts
Chappell GA, Heintz MM, Borghoff SJ, Doepker CL, Wikoff DS . 2021. Lack of potential carcinogenicity for steviol glycosides — Systematic evaluation and integration of mechanistic data into the totality of evidence. Food Chem Toxicol 150:112045.
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Publication: Manuscripts
Felter SP, Zhang X, Thompson C . 2021. Butylated hydroxyanisole: Carcinogenic food additive to be avoided or harmless antioxidant important to protect food supply? Regul Toxicol Pharmacol 121:104887.
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Publication: Manuscripts
Thompson CM , Gentry R, Fitch S , Lu K, Clewell HJ. 2020. An updated mode of action and human relevance framework evaluation for formaldehyde-related nasal tumors. Crit Rev Toxicol 50(10):919–952, DOI: 10.1080/10408444.2020.1854679.
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Publication: Manuscripts
Gentry R, Thompson CM , Franzen A , Salley J, Albertini R, Lu K, Greene T. 2020. Using mechanistic information to support evidence integration and synthesis: A case study with inhaled formaldehyde and leukemia. Crit Rev Toxicol 50(10):885–918, DOI: 10.1080/10408444.2020.1854678.
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Publication: Manuscripts
Wikoff DS , Urban JD , Ring C, Britt J , Fitch S , Haws LC . 2021. Development of a range of plausible non-cancer toxicity values for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) based on effects on sperm count: Application of systematic review methods and quantitative integration of dose response using meta-regression. Toxicol Sci 179(2):162-182, https://doi.org/10.1093/toxsci/kfaa171.
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Publication: Manuscripts
Chappell GA, Heintz MM , Haws LC . 2021. Transcriptomic analyses of livers from mice exposed to 1,4-dioxane for up to 90 days to assess potential mode(s) of action underlying liver tumor development. Curr Res Toxicol 2:30–41.
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Publication: Manuscripts
Chappell GA, Wikoff DS , Thompson CM . 2021. Assessment of mechanistic data for hexavalent chromium-induced rodent intestinal cancer using the key characteristics of carcinogens. Toxicol Sci 180(1):38–50.
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Publication: Manuscripts
2020
Eichenbaum G, Yang K, Gebremichael Y, Howell BA, Murray FJ, Jacobson-Kram D, Jaeschke H, Kuffner E, Gelotte CK, Lai JCK, Wikoff D , Atillasoy E. 2020. Application of the DILIsym® Quantitative Systems Toxicology drug-induced liver injury model to evaluate the carcinogenic hazard potential of acetaminophen. Regul Toxicol Pharmacol 118:104788.
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