Systematic review protocol development and publication
- PECO and PICO questions
- Analytic framework
- Conflict of interest
- Expert review team selection and management
- Research strategy design
- Software selection tools
Systematic review implementation
- Topic-specific search strategies
- Inclusion and exclusion criteria
- Study screening and data extraction
- Evidence tables
Assessment of individual studies
- Qualitative and quantitative study ranking
- Risk of bias
Body-of-Evidence integration (weight of the evidence)
- Synthesis of body of literature
- Confidence ratings
- Meta-analysis
- Dose-response assessment
- Evaluation of lines of evidence
- Assessment of adverse outcome pathways
- Causation analyses
- Evidence-based conclusions
- Reporting and publication