Frameworks for incorporation of new-approach method (NAM) testing strategies
Adverse Outcome Pathway (AOP) development and application to support:
- Fit-for-purpose in vitro assay design
- Mode-of-action identification
Computational toxicology
- Integration of in vivo and in vitro toxicity data using in silico models
- Bioinformatics, including -omics data
- QSAR
- Development of custom structure activity and machine learning models
- Pathway-based computational systems biology models
- Dose-response modeling
Tiered testing strategies
- Interpretation of high-throughput screening (HTS) data
- Chemical prioritization
- Margin of exposure
- Organotypic in vitro models
- Dose-response analysis
- Defining a region of safety for chemical exposure
- Targeted in vivo models
- Validation and ground-truthing of in vitro assay and in silico predictions
Supporting risk-based decisions
- Mode of action
- Point of departure