Physiologically based pharmacokinetic modeling (PBPK)
- Custom model development
- Rapid PBPK (HT-PBPK) for early discovery and prioritization
- Dose, route, and species extrapolation
- Early life and other sensitive populations
- Regulatory submission
In vitro-to-in vivo extrapolation (IVIVE)
- Quantitative IVIVE of cell-based toxicity assay results
- High-throughput IVIVE (HT IVIVE) of in vitro screening assays
- Derivation of Oral Equivalent Dose (OED) and Activity-to-Exposure Ratio (AER) from HT in vitro data
In vitro metabolism studies
- Intrinsic clearance (Clint)
- Enzyme kinetic assays for IVIVE and PBPK parameterization
In vitro assay designs and in vitro biokinetics
- Repeated dosing in vitro in long-term cultures
- HT and fit-for-purpose metabolism assays in organotypic culture models
- Biokinetic modeling of in vitro assay systems